DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5022 and epb41b

DIOPT Version :9

Sequence 1:	NP_609384.1	Gene:	CG5022 / 34398	FlyBaseID:	FBgn0032225	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_778259.1	Gene:	epb41b / 326287	ZFINID:	ZDB-GENE-030130-1	Length:	1534	Species:	Danio rerio

Alignment Length:	398	Identity:	127/398 - (31%)
Similarity:	193/398 - (48%)	Gaps:	41/398 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 KCTVRLLDDSDVLECEFQPFHKGIYLLEYLCGELEIKEKDYFGLRYVDSSKQRHWLDLSKSIIKQ 77
            :|.|..|||: :...|.:....|..|...:|..|.:.|:|||||...||...|.|||.:|.|.||
Zfish     3 QCRVNFLDDT-LFTWELERDSLGQDLFNKVCEHLNLLERDYFGLVMWDSPTNRVWLDCAKEIRKQ 66

  Fly    78 CKEMDPLL-FSLRVKFYPADPFRLTGN-ARIMLYQQLKRDLRHGRLYCSLGEAAALGALIVQEEL 140
            .|  .|:. |...:||||.||..|..: .|..|...|::|:..|||.|.....|.||:..||..|
Zfish    67 IK--SPVAEFFFSIKFYPPDPSILAEDITRYFLCLHLRKDILIGRLPCPSDILALLGSYTVQSTL 129

  Fly   141 GDYNEDVHVGSYVSSIELALRQTECLEKKIIELH---KKREPGQNLSLAMDEFLGIARGLETYGI 202
            |||:.::|..:||..|.||..|::.||:|::|||   :...|.|...|    ||....||..||:
Zfish   130 GDYDPNLHKNNYVRKIVLAPNQSKELEEKVMELHATYRFMSPAQADLL----FLENVMGLPMYGV 190

  Fly   203 DPHPVKDHRGSQQYVGINNTGISTFVAGKRSQHFRWNEIHKINFEGKMFIAHL--SYTDASREPK 265
            |.||.||..|....:|:.:.|:..:..|.::..|.|..:.||:.:...|:..:  |..|||
Zfish   191 DLHPAKDASGEDVMLGVCSEGLIVYEDGVKTNSFFWPRVLKISHKRNTFLLKMRPSEEDAS---- 251

  Fly   266 KHTVGFKCPTGAACRYLWRCAIEQMLFF--TLPNSQSAAVISGGGFFSWGTKFRYTGRTEREILT 328
            :..:.|......||:.||:|::|...||  .|.::::..::      :.|::|||.||.:.|.:.
Zfish   252 EGNLSFSLANYRACKQLWKCSVEHHSFFRNRLQDTKAKRLL------TLGSRFRYHGRKQSECVE 310

  Fly   329 ENINALREQKNNSN-SSKRKASSVPATPSSPQGDLAQIRYSSLP-RSTMSE-PLGYGMPNGHFYG 390
            .:.|..|.....:. |.||||:.          ::..:  ..|| |:.:.: .|.||....|.|.
Zfish   311 ASSNITRAPPRFTRYSIKRKANE----------EILDV--LKLPVRAEVDDWFLVYGPEKWHIYT 363

  Fly   391 HDHGMSDA 398
            .|..|.::
Zfish   364 SDDVMLES 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5022	NP_609384.1	B41	13..205	CDD:214604	76/196 (39%)
		FERM_N	16..80	CDD:286467	25/63 (40%)
		FERM_M	108..205	CDD:278785	39/99 (39%)
		FERM_C_FRMD3_FRMD5	186..294	CDD:270013	33/111 (30%)
		FA	308..349	CDD:285894	13/41 (32%)
epb41b	NP_778259.1	B41	4..193	CDD:214604	76/195 (39%)
		FERM_N	6..69	CDD:286467	26/65 (40%)
		FERM_M	88..193	CDD:278785	41/108 (38%)
		FERM_C_4_1_family	188..281	CDD:270005	29/96 (30%)
		FA	290..331	CDD:285894	12/46 (26%)
		SAB	1451..1497	CDD:282265
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586156
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740