DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5022 and Epb41

DIOPT Version :9

Sequence 1:	NP_609384.1	Gene:	CG5022 / 34398	FlyBaseID:	FBgn0032225	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	XP_038967185.1	Gene:	Epb41 / 313052	RGDID:	1564762	Length:	1069	Species:	Rattus norvegicus

Alignment Length:	385	Identity:	139/385 - (36%)
Similarity:	203/385 - (52%)	Gaps:	34/385 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 CTVRLLDDSDVLECEFQPFHKGIYLLEYLCGELEIKEKDYFGLRYVDSSKQRHWLDLSKSIIKQC 78
            |.|.||||: |.||..:...||..||:.:|..|.:.|:|||||...||:..:.|||.:|.|.||.
  Rat   255 CKVSLLDDT-VYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLAVWDSTTSKTWLDSAKEIKKQV 318

  Fly    79 KEMDPLLFSLRVKFYPADPFRLTGN-ARIMLYQQLKRDLRHGRLYCSLGEAAALGALIVQEELGD 142
            :.: |..|:..|||||.||.:||.: .|..|..||::|:..|||.||....|.||:..||.||||
  Rat   319 RGV-PWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTVQSELGD 382

  Fly   143 YNEDVHVGSYVSSIELALRQTECLEKKIIELHK---KREPGQNLSLAMDEFLGIARGLETYGIDP 204
            |:.::|...|||..:||..||..||:|::||||   ...|.|    |..|||..|:.|..||:|.
  Rat   383 YDPELHGVDYVSDFKLAPNQTRELEEKVMELHKSYRSMTPAQ----ADLEFLENAKKLSMYGVDL 443

  Fly   205 HPVKDHRGSQQYVGINNTGISTFVAGKRSQHFRWNEIHKINFEGKMFIAHLSYTDASREPKKHTV 269
            |..||..|....:|:.::|:..:....|...|.|.::.||:::...|.  :......:|..:.|:
  Rat   444 HKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFF--IKIRPGEQEHYESTI 506

  Fly   270 GFKCPTGAACRYLWRCAIEQMLFF------TLPNSQSAAVISGGGFFSWGTKFRYTGRTEREILT 328
            |||.|:..|.:.||:..:|...||      |||.|:         |.:.|:||||:|||:.:  |
  Rat   507 GFKLPSYRAAKKLWKVCVEHHTFFRLTSTDTLPKSK---------FLALGSKFRYSGRTQAQ--T 560

  Fly   329 ENINALREQKN---NSNSSKRKASSVPATPSSPQGDLAQIRYSSLPRSTMSEPL-GYGMP 384
            ...:||.::..   ...:|||.:.|:....::...|.:. |.:|.|....|:.: |.|.|
  Rat   561 RQASALIDRPAPHFERTASKRASRSLDGAAAAESTDRSP-RPTSAPAIAQSQVMEGPGAP 619

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5022	NP_609384.1	B41	13..205	CDD:214604	87/194 (45%)
		FERM_N	16..80	CDD:286467	29/63 (46%)
		FERM_M	108..205	CDD:278785	45/99 (45%)
		FERM_C_FRMD3_FRMD5	186..294	CDD:270013	33/113 (29%)
		FA	308..349	CDD:285894	15/43 (35%)
Epb41	XP_038967185.1	B41	254..444	CDD:214604	87/194 (45%)
		FERM_C_4_1_family	439..532	CDD:270005	27/94 (29%)
		FA	542..585	CDD:400882	15/53 (28%)
		SAB	702..750	CDD:398195
		4_1_CTD	959..1065	CDD:399118
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345129
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.740