DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5022 and Epb41l2

DIOPT Version :9

Sequence 1:	NP_609384.1	Gene:	CG5022 / 34398	FlyBaseID:	FBgn0032225	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	XP_017445330.1	Gene:	Epb41l2 / 309557	RGDID:	1563977	Length:	1101	Species:	Rattus norvegicus

Alignment Length:	427	Identity:	128/427 - (29%)
Similarity:	207/427 - (48%)	Gaps:	25/427 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SKNEGNIVYKCTVRLLDDSDVLECEFQPFHKGIYLLEYLCGELEIKEKDYFGLRYVDSSKQRHWL 68
            :|....::.|.|  |||.:: ..|:.:...||..|.:.:|..|.:.|||||||.:.:..:|::||
  Rat   207 AKKTKTVLAKVT--LLDGTE-FSCDLEKRAKGQALFDRVCEHLNLLEKDYFGLIFQEHPEQKNWL 268

  Fly    69 DLSKSIIKQCKEMDPLLFSLRVKFYPADPFRLTGN-ARIMLYQQLKRDLRHGRLYCSLGEAAALG 132
            |.:|.|.:|.:.: |.||:..|||||.||.:||.: .|..|..||::|:..|||.||....|.||
  Rat   269 DPAKEIKRQLRSL-PWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDISSGRLPCSFVTHALLG 332

  Fly   133 ALIVQEELGDYNEDVHVGSYVSSIELALRQTECLEKKIIELHKKREPGQNLSLAMDEFLGIARGL 197
            :..:|.|.|||:.:.:....:...:.|....:.||:|:.||||... |.:.:.|..:||..|:.|
  Rat   333 SYTLQAEHGDYDPEEYDSIDLGDFQFAPTHNKELEEKVAELHKTHR-GLSPAQADSQFLENAKRL 396

  Fly   198 ETYGIDPHPVKDHRGSQQYVGINNTGISTFVAGKRSQHFRWNEIHKINFEGKMFIAHLSYTDASR 262
            ..||:|.|..||..|....:|:...|:..:....|...|.|.:|.||:::...|  ::.......
  Rat   397 SMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNF--YIKVRPGEL 459

  Fly   263 EPKKHTVGFKCPTGAACRYLWRCAIEQMLFFTLPNSQSAAVISGGGFFSWGTKFRYTGRTEREIL 327
            |..:.|:|||.|...|.:.||:..:|...|:.|.:.:......   |.:.|:||||:|||:.:
  Rat   460 EQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKTK---FLTLGSKFRYSGRTQAQ-- 519

  Fly   328 TENINALREQ---KNNSNSSKRKASSVPATPSSPQGDLAQIRYSSLPRSTMSEPLGYG-MPNGHF 388
            |...:.|.::   :....||||.:.|:   ..:|.|.:.|......|     .|.|.| :|....
  Rat   520 TREASTLIDRPAPQFERASSKRVSRSL---DGAPIGVVDQSLMKDFP-----GPPGEGSVPGPGV 576

  Fly   389 YGHDHGMSDANGGIQISSLEPVCEEARLRSSNIDGVN 425
            ..:.........|...:.:.|:..|.:..:..:||.|
  Rat   577 VSYTTVQDGRRDGKSPTKVTPLLAEGKKNTLRVDGDN 613

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5022	NP_609384.1	B41	13..205	CDD:214604	72/192 (38%)
		FERM_N	16..80	CDD:286467	23/63 (37%)
		FERM_M	108..205	CDD:278785	34/96 (35%)
		FERM_C_FRMD3_FRMD5	186..294	CDD:270013	32/107 (30%)
		FA	308..349	CDD:285894	15/43 (35%)
Epb41l2	XP_017445330.1	PTZ00121	<4..>216	CDD:173412	1/8 (13%)
		B41	215..404	CDD:214604	72/193 (37%)
		FERM_C_4_1_family	399..492	CDD:270005	27/94 (29%)
		FA	502..545	CDD:400882	15/47 (32%)
		SAB	622..662	CDD:398195
		4_1_CTD	989..1094	CDD:399118
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345136
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840