DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5022 and Epb41

DIOPT Version :9

Sequence 1:	NP_609384.1	Gene:	CG5022 / 34398	FlyBaseID:	FBgn0032225	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	XP_006538970.1	Gene:	Epb41 / 269587	MGIID:	95401	Length:	1025	Species:	Mus musculus

Alignment Length:	379	Identity:	136/379 - (35%)
Similarity:	203/379 - (53%)	Gaps:	22/379 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 CTVRLLDDSDVLECEFQPFHKGIYLLEYLCGELEIKEKDYFGLRYVDSSKQRHWLDLSKSIIKQC 78
            |.|.||||: |.||..:...||..||:.:|..|.:.|:|||||...||:..:.|||.:|.|.||.
Mouse   213 CKVSLLDDT-VYECVVEKHAKGQDLLKRVCEHLNLLEEDYFGLALWDSATSKTWLDSAKEIKKQV 276

  Fly    79 KEMDPLLFSLRVKFYPADPFRLTGN-ARIMLYQQLKRDLRHGRLYCSLGEAAALGALIVQEELGD 142
            :.: |..|:..|||||.||.:||.: .|..|..||::|:..|||.||....|.||:..:|.||||
Mouse   277 RGV-PWNFTFNVKFYPPDPAQLTEDITRYYLCLQLRQDIVAGRLPCSFATLALLGSYTIQSELGD 340

  Fly   143 YNEDVHVGSYVSSIELALRQTECLEKKIIELHK---KREPGQNLSLAMDEFLGIARGLETYGIDP 204
            |:.::|...|||..:||..||:.||:|::||||   ...|.|    |..|||..|:.|..||:|.
Mouse   341 YDPELHGMDYVSDFKLAPNQTKELEEKVMELHKSYRSMTPAQ----ADLEFLENAKKLSMYGVDL 401

  Fly   205 HPVKDHRGSQQYVGINNTGISTFVAGKRSQHFRWNEIHKINFEGKMFIAHLSYTDASREPKKHTV 269
            |..||..|....:|:.::|:..:....|...|.|.::.||:::...|.  :......:|..:.|:
Mouse   402 HKAKDLEGVDIILGVCSSGLLVYKDKLRINRFPWPKVLKISYKRSSFF--IKIRPGEQEHYESTI 464

  Fly   270 GFKCPTGAACRYLWRCAIEQMLFFTLPNSQSAAVISGGGFFSWGTKFRYTGRTEREILTENINAL 334
            |||.|:..|.:.||:..:|...||.|.::.:   |....|.:.|:||||:|||:.:  |...:||
Mouse   465 GFKLPSYRAAKKLWKVCVEHHTFFRLTSTDT---IPKSKFLALGSKFRYSGRTQAQ--TRQASAL 524

  Fly   335 REQKN---NSNSSKRKASSVPATPSSPQGDLAQIRYSSLPRSTMSEPL-GYGMP 384
            .::..   ...:|||.:.|:....::...|.:. |.:|.|....|:.. |.|.|
Mouse   525 IDRPAPHFERTASKRASRSLDGAAAAESTDRSP-RPTSAPAIAQSQVTEGPGAP 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5022	NP_609384.1	B41	13..205	CDD:214604	86/194 (44%)
		FERM_N	16..80	CDD:286467	29/63 (46%)
		FERM_M	108..205	CDD:278785	44/99 (44%)
		FERM_C_FRMD3_FRMD5	186..294	CDD:270013	32/107 (30%)
		FA	308..349	CDD:285894	15/43 (35%)
Epb41	XP_006538970.1	B41	212..402	CDD:214604	86/194 (44%)
		FERM_C_4_1_family	397..490	CDD:270005	27/94 (29%)
		FA	500..542	CDD:370090	15/43 (35%)
		SAB	662..709	CDD:367916
		4_1_CTD	915..1021	CDD:368659
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841754
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840