DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5022 and Frmd6

DIOPT Version :9

Sequence 1:	NP_609384.1	Gene:	CG5022 / 34398	FlyBaseID:	FBgn0032225	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	XP_006240213.1	Gene:	Frmd6 / 257646	RGDID:	727810	Length:	622	Species:	Rattus norvegicus

Alignment Length:	503	Identity:	109/503 - (21%)
Similarity:	185/503 - (36%)	Gaps:	129/503 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 CEFQPFHKGI-----------YLLEYLCGELEIKEKDYFGLRYVDSSKQRHWLDLSKSIIKQC-- 78
            |.|.|..|.:           .||..:|..|.:|:...|||..:.:: :..:::||:.:.|.|
  Rat    19 CIFLPNDKSVSIIINVKILCHQLLVQVCDLLRLKDSHLFGLSVIQNN-EHVYMELSQKLYKYCPK 82

  Fly    79 ---KEMD----------------PLLFSLRVKFYPADPFRLTGN-ARIMLYQQLKRDLRHGRLYC 123
               ||..                |::...||::|..:...::.. ||...|..|::.:.|.:  |
  Rat    83 EWKKEASKVRQYEVTWGIDQFGPPMIIHFRVQYYVENGKLISDRIARYYYYWHLRKQVLHSQ--C 145

  Fly   124 SLGEAA--ALGALIVQEELGDYNEDVHVG------SYVSSIELALRQTECLEKKIIELHKKREPG 180
            .|.|.|  .|.|..:|.:||::...||.|      :|..:..::.|..:.:.|.|..:|:
  Rat   146 VLREEAYFLLAAFALQADLGNFKRKVHHGDYFEPEAYFPAWVVSKRGKDYILKHIPNMHR----- 205

  Fly   181 QNLSLAMDE----FLGIARGLETYGIDPHPV-KDHR---GSQQYVGINNTGISTFVAGKRSQH-- 235
            ...:|...|    ::..|..|:...|..:.: ||.|   ||.. :|:...||..|...:..:.
  Rat   206 DQFALTASEAYLKYIKEAVRLDDVAIHYYRLYKDKREVEGSLT-LGLTMRGIQIFQNLEEEKQLL 269

  Fly   236 --FRWNEIHKINFEGKMFIAHLSYTDASREPKKHTVGFKCPTGAACRYLWRCAIEQMLFFTLPNS 298
              |.|..:.|:.|.||.|..   ..|.....:|......|||.:  |:|.:         .|.||
  Rat   270 YDFPWTNVGKLVFVGKKFEI---LPDGLPSARKLVYYTGCPTRS--RHLLQ---------LLSNS 320

  Fly   299 QSAAVISGGGFFSWGTKFRYTGRTE--------RE-ILTENI----NALREQKNNSNSS----KR 346
            ...       :.:.....|:..:.|        || .:::|:    :.|.::...|.||    |.
  Rat   321 HRL-------YMNLQPVLRHLRKQEENEEKKQYRESYISDNLDLDMDPLEKRSRASGSSAGSMKH 378

  Fly   347 KASSVPATPSSPQGDLAQIRYSSLPRSTMSEPLGYGMPNGHFYGHDHGMSDA-NGGIQISSLEPV 410
            |..|..:|.|......:.|...:.||                   |.|..|. :|.:....|:..
  Rat   379 KRLSRHSTASHSSSHTSGIETDTKPR-------------------DPGPEDGYSGSVMHRKLKTC 424

  Fly   411 CEEARLRSSNIDGVNYLASQIGGYAYRDSVEHSSTESGLTVNGYDHPR 458
            .......||:..||     :.||   :|.:|..|.:..:.:. .|.||
  Rat   425 SSMTSHGSSHTSGV-----ESGG---KDRLEEDSQDDEIEML-VDDPR 463

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5022	NP_609384.1	B41	13..205	CDD:214604	49/222 (22%)
		FERM_N	16..80	CDD:286467	16/68 (24%)
		FERM_M	108..205	CDD:278785	25/108 (23%)
		FERM_C_FRMD3_FRMD5	186..294	CDD:270013	27/119 (23%)
		FA	308..349	CDD:285894	11/57 (19%)
Frmd6	XP_006240213.1	B41	20..234	CDD:214604	48/221 (22%)
		FERM_N	20..82	CDD:286467	15/62 (24%)
		FERM_M	123..234	CDD:278785	27/117 (23%)
		FERM_C_FRMD1_FRMD6	227..335	CDD:270006	28/129 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166345144
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930