Protein Alignment CG5022 and Frmd3

DIOPT Version :9

• Sequence 1: NP_609384.1
• Gene: CG5022 / 34398
• FlyBaseID: FBgn0032225
• Length: 572
• Species: Drosophila melanogaster
• Sequence 2: NP_766457.1
• Gene: Frmd3 / 242506
• MGIID: 2442466
• Length: 595
• Species: Mus musculus
• Alignment Length: 614
• Identity: 197/614 - (32%)
• Similarity: 293/614 - (47%)
• Gaps: 96/614 - (15%)

  Fly     2 FRSKN--EGNIVYKCTVRLLDDSDVLECEFQPFHKGIYLLEYLCGELEIKEKDYFGLRYVDSSKQ 64
            |||.:  ..|...|||:||||||:| .|..|...||.:|:||:|....:.||||||:||||..||
Mouse    20 FRSSSIKSLNQEMKCTIRLLDDSEV-SCHIQRETKGQFLIEYICNYYSLLEKDYFGIRYVDPEKQ 83

  Fly    65 RHWLDLSKSIIKQCKEMDPLLFSLRVKFYPADPFRLTGN-ARIMLYQQLKRDLRHGRLYCSLGEA 128
            ||||:.:|||.||.|...|.....||||||.:|.::... .|.:||.|:|||:.||||.||..:|
Mouse    84 RHWLEPNKSIFKQMKSHPPYTMCFRVKFYPHEPLKIKEELTRYLLYLQIKRDIFHGRLLCSFSDA 148

  Fly   129 AALGALIVQEELGDYNEDVHVGSYVSSIELALRQTECLEKKIIELHKKREPGQNLSLAMDEFLGI 193
            |.|||.|||.|.|||..|.|..:|:|..|:..:|::.||:||:|:|.....||:.::|....|..
Mouse   149 AYLGACIVQAEFGDYYPDEHPENYISEFEIFPKQSQKLERKIMEIHNNELRGQSPAIAEFNLLLK 213

  Fly   194 ARGLETYGIDPHPVKDHRGSQQYVGINNTGISTFVAGKRSQHFRWNEIHKINFEGKMFIAHLSYT 258
            |..|||||:||||.||.||:..::|....|...|...||....:|:::.|:.||||.|     |.
Mouse   214 AHTLETYGVDPHPCKDSRGATAFLGFTAAGFVVFQGNKRIHLRKWSDVCKLKFEGKTF-----YV 273

  Fly   259 DASREPKKHTVGFKCPTGAACRYLWRCAIEQMLFFTLPNSQSAAVISGGGFFSWGTKFRYTGRTE 323
            ..|::.|...:.|...|.|||::||:|.:|...|:....|.....:|....|..|::|||:|:..
Mouse   274 IGSQKEKNAVLAFHTSTPAACKHLWKCGVENQAFYKYAKSSQIKTVSSSKIFFKGSRFRYSGKVA 338

  Fly   324 REIL------------TENINALREQKNNSNSSKRKASSVPATP--SSPQGDLAQIRYSS---LP 371
            :|::            ...:|..:.:..:|.:.:...:..|..|  .||.....::....   ||
Mouse   339 KEVVEASSKIQRDPPEVHRVNITQSRSFHSLNKQLIINMEPLQPLLPSPTEQEEEVPVGEGVPLP 403

  Fly   372 RSTMSEPLGYGMPNGHFYGHDHGMSDANGGIQISSLEPVCEEARLRSSNI--------------- 421
            :..:||||....|              ..|.|.:. .|..||.|::...:
Mouse   404 KMDVSEPLIASSP--------------VKGAQCAD-PPDEEEDRVKEDPLTISELAYNPSASLLP 453

  Fly   422 -----DGVNYLASQIGGYAYRDSVEHSSTESGLTVNGYDH------PRKHNEARQHGSYSPNLYY 475
                 |.:|.|..    ...|..:|...|:|...:...::      ..:..||||..|:|.::..
Mouse   454 TPVDDDEINMLFD----CPSRLELEREDTDSFEELEADENAFLIAEEEELKEARQALSWSYSILT 514

  Fly   476 GQSDGAVNSSSPADSFLHADPSTRKVKKFRKFHLLHAFVPSVIFVAFAMAGTAVFIMES--ESEA 538
            |.              :..:|   .||.|.:  ||...:..::|| |.:   .:.::||  :...
Mouse   515 GH--------------IWVNP---LVKSFSR--LLVVGLGLLLFV-FPL---LLLLLESGIDLSF 556

  Fly   539 FEQLRNSPEMLCLRYQYYQPLKEFVLEKL 567
            ..::|.:||.....|:||.||||:|..|:
Mouse   557 LCEIRQTPEFEQFHYEYYCPLKEWVAGKV 585

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5022	NP_609384.1	B41	13..205	CDD:214604	96/192 (50%)
		FERM_N	16..80	CDD:286467	36/63 (57%)
		FERM_M	108..205	CDD:278785	47/96 (49%)
		FERM_C_FRMD3_FRMD5	186..294	CDD:270013	41/107 (38%)
		FA	308..349	CDD:285894	9/52 (17%)
Frmd3	NP_766457.1	B41	33..225	CDD:214604	96/192 (50%)
		FERM_N	36..99	CDD:286467	36/63 (57%)
		FERM_M	117..225	CDD:278785	48/107 (45%)
		PH-like	206..309	CDD:302622	41/107 (38%)
		FA	323..>357	CDD:285894	7/33 (21%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841762
Domainoid	1	1.000	79	1.000	Domainoid score	I8666
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	306	1.000	Inparanoid score	I2608
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D227685at33208
OrthoFinder	1	1.000	-	-		FOG0002996
OrthoInspector	1	1.000	-	-		otm43767
orthoMCL	1	0.900	-	-		OOG6_105621
Panther	1	1.100	-	-	LDO	PTHR23280
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7059
SonicParanoid	1	1.000	-	-		X1988
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	14	13.830