Protein Alignment CG5022 and Frmd5

DIOPT Version :9

• Sequence 1: NP_609384.1
• Gene: CG5022 / 34398
• FlyBaseID: FBgn0032225
• Length: 572
• Species: Drosophila melanogaster
• Sequence 2: XP_011237768.1
• Gene: Frmd5 / 228564
• MGIID: 2442557
• Length: 599
• Species: Mus musculus
• Alignment Length: 630
• Identity: 191/630 - (30%)
• Similarity: 266/630 - (42%)
• Gaps: 131/630 - (20%)

  Fly    12 YKCTVRLLDDSDVLECEFQPFHKGIYLLEYLCGELEIKEKDYFGLRYVDSSKQRHWLDLSKSIIK 76
            |.|||||||||: ..|..|...||.||.:.||..|.:.||||||:|:||..||||||:.:||::|
Mouse    17 YSCTVRLLDDSE-YTCTIQRDAKGQYLFDLLCHHLNLLEKDYFGIRFVDPDKQRHWLEFTKSVVK 80

  Fly    77 QCKEMDPLLFSLRVKFYPADPFRLTGN-ARIMLYQQLKRDLRHGRLYCSLGEAAALGALIVQEEL 140
            |.:...|.....|||||||||..|... .|.:::.|:||||.||||.|...:||.|.|.|:|.|:
Mouse    81 QLRSQPPFTMCFRVKFYPADPAALKEEITRYLVFLQIKRDLYHGRLLCKTSDAALLAAYILQAEI 145

  Fly   141 GDYNEDVHVGSYVSSIELALRQTECLEKKIIELHKKREPGQNLSLAMDEFLGIARGLETYGIDPH 205
            |||:...|...|.|..:...:.:|.|||||.|:||....||..:.:...||..|:.|||||:|||
Mouse   146 GDYDPGKHPEGYSSKFQFFPKHSEKLEKKIAEIHKTELSGQTPATSELNFLRKAQTLETYGVDPH 210

  Fly   206 PVKDHRGSQQYVGINNTGISTFVAGKRSQHF------------------------------RWNE 240
            |.||..|:..::.....|. ..:.|.:..||                              .|||
Mouse   211 PCKDVSGNAAFLAFTPFGF-VVLQGNKRVHFIKCILFASFTAAIHWAGGFKDFSTITPKPLSWNE 274

  Fly   241 IHKINFEGKMFIAHLSYTDASREPKKHTVGFKCPTGAACRYLWRCAIEQMLFFTLPNSQSAAVIS 305
            :.|:.||||.|..::|    .:|.||..:.:..||..||::||:|.||...|:.|..|.....:|
Mouse   275 VTKLKFEGKTFYLYVS----QKEEKKIILTYFAPTPEACKHLWKCGIENQAFYKLEKSSQVRTVS 335

  Fly   306 GGGFFSWGTKFRYTGRTEREILTENINALREQKNNSNSSKRKASSVPATPSSPQGDLAQIRYSSL 370
            ....|..|::|||:||..:|::..:....||......:....:.|.|:....|       |.||:
Mouse   336 SSNLFFKGSRFRYSGRVAKEVMESSAKIKREPPEIHRAGMVPSRSCPSITHGP-------RLSSV 393

  Fly   371 PR-------------------STMSEPLGYGMPNGHFYGH-DHGMSDANGGIQISSLE------- 408
            ||                   |..|.|:........|..| ....:|:|..:.:.:.|
Mouse   394 PRTRRRAVHISIMEGLESLRDSAHSTPVRSSSHGDTFLPHVRSSRADSNERVAVIADEAYSPADS 458

  Fly   409 ----PVCE---EARLRSSNIDGVNYLASQIGGYAYRDSVEHSSTESGLTVNGYDHPRKHNEARQH 466
                ||.|   |..|.|..|:|...            |:|........|...       .||...
Mouse   459 VLPTPVAEHSLELMLLSRQINGATC------------SIEEEKESEASTPTA-------TEAEAL 504

  Fly   467 GSYSPNLYYGQSDGAVNSSSPADSFLHADPSTRKVKKFRKFHLLHAFVPSVIFVAFAMAG----- 526
            |.....|..|                |......:|.|         ||.||:.:.....|
Mouse   505 GGELRALCQG----------------HGGSEQEQVNK---------FVLSVLRLLLVTMGLLFVL 544

  Fly   527 --TAVFIMESESEA--FEQLRNSPEMLCLRYQYYQPLKEFVLEKL 567
              ..:.:.||:.:.  |..:|.:||.....|||:.||:.:...|:
Mouse   545 LLLLIILTESDLDVAFFRDIRQTPEFEQFHYQYFCPLRRWFACKI 589

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5022	NP_609384.1	B41	13..205	CDD:214604	92/192 (48%)
		FERM_N	16..80	CDD:286467	35/63 (56%)
		FERM_M	108..205	CDD:278785	43/96 (45%)
		FERM_C_FRMD3_FRMD5	186..294	CDD:270013	42/137 (31%)
		FA	308..349	CDD:285894	10/40 (25%)
Frmd5	XP_011237768.1	B41	19..210	CDD:214604	92/191 (48%)
		PH-like	191..324	CDD:388408	42/137 (31%)
		FA	338..383	CDD:370090	11/44 (25%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841760
Domainoid	1	1.000	79	1.000	Domainoid score	I8666
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	306	1.000	Inparanoid score	I2608
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002996
OrthoInspector	1	1.000	-	-		otm43767
orthoMCL	1	0.900	-	-		OOG6_105621
Panther	1	1.100	-	-	O	PTHR23280
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7059
SonicParanoid	1	1.000	-	-		X1988
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	11.820