DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5022 and Epb41l5

DIOPT Version :9

Sequence 1:	NP_609384.1	Gene:	CG5022 / 34398	FlyBaseID:	FBgn0032225	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_663481.2	Gene:	Epb41l5 / 226352	MGIID:	103006	Length:	731	Species:	Mus musculus

Alignment Length:	421	Identity:	135/421 - (32%)
Similarity:	200/421 - (47%)	Gaps:	54/421 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VYKCTVRLLDDSDVLECEFQPFHKGIYLLEYLCGELEIKEKDYFGLRYVDSSKQRHWLDLSKSII 75
            :..|.|.|||.:|| ..:.....||..|.:.:...|::.|.||||||::||::..||||.:|||.
Mouse    42 IITCRVSLLDGTDV-SVDLPKKAKGQELFDQIMYHLDLIESDYFGLRFMDSAQVAHWLDGTKSIK 105

  Fly    76 KQCKEMDPLLFSLRVKFYPADPFRLTGN-ARIMLYQQLKRDLRHGRLYCSLGEAAALGALIVQEE 139
            ||.|...|....||||||.::|..|... .|.:...|||:|:..|:|.|....|..|.|..:|.|
Mouse   106 KQVKIGSPYCLHLRVKFYSSEPNNLREELTRYLFVLQLKQDILSGKLECPFDTAVQLAAYNLQAE 170

  Fly   140 LGDYNEDVHVGSYVSSIELALRQTECLEKKIIELHKKREPGQNLSLAMDEFLGIARGLETYGIDP 204
            ||||:...|....||.......|||.:|..|.|..|:.. ||..:.|...:|..|:.||.||:|.
Mouse   171 LGDYDLAEHSPELVSEFRFVPIQTEEMELAIFEKWKEYR-GQTPAQAETNYLNKAKWLEMYGVDM 234

  Fly   205 HPVKDHRGSQQYVGINNTGISTFVAGKRSQHFRWNEIHKINF-EGKMFIAHLSYTDASREPKKHT 268
            |.||...|:...:|:..||:..|....:...|.|.:|.:::| :.|:.:..:...|..:| ::||
Mouse   235 HVVKARDGNDYSLGLTPTGVLVFEGETKIGLFFWPKITRLDFKKNKLTLVVVEDDDQGKE-QEHT 298

  Fly   269 VGFKCPTGAACRYLWRCAIEQMLFFTL--PNSQSAAVISGGGFFSWGTKFRYTGRTEREILTEN- 330
            ..|:.....||::||:||:|...||.|  |..:|:   ...||...|::|||:|:||.:....|
Mouse   299 FVFRLDHPKACKHLWKCAVEHHAFFRLRGPVQKSS---HRSGFIRLGSRFRYSGKTEYQTTKTNK 360

  Fly   331 ----------------------------------INALREQKNNSNSSKRKASSVPATPSSPQGD 361
                                              :|| ..||::|..:....|.||.|.||..|
Mouse   361 ARRSTSFERRPSKRYSRRTLQMKASTTQPEDLGVLNA-SAQKSDSQQAWGVMSPVPVTSSSSCG- 423

  Fly   362 LAQIRYSSLPRSTMSE-------PLGYGMPN 385
            ..|:...:||:::.:|       ||...:.|
Mouse   424 AVQVEIENLPQTSATEQHDRKCLPLSVDLLN 454

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5022	NP_609384.1	B41	13..205	CDD:214604	76/192 (40%)
		FERM_N	16..80	CDD:286467	28/63 (44%)
		FERM_M	108..205	CDD:278785	36/96 (38%)
		FERM_C_FRMD3_FRMD5	186..294	CDD:270013	34/108 (31%)
		FA	308..349	CDD:285894	15/75 (20%)
Epb41l5	NP_663481.2	Required for interaction with CRB1. /evidence=ECO:0000250\|UniProtKB:Q9HCM4	29..119		31/77 (40%)
		FERM_F1_EPB41L5	41..126	CDD:340725	37/84 (44%)
		B41	44..235	CDD:214604	76/192 (40%)
		FERM_C_NBL4_NBL5	231..324	CDD:270007	28/93 (30%)
		FA	337..377	CDD:370090	10/39 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	352..388		2/35 (6%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841766
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840