Protein Alignment CG5022 and EPB41L2

DIOPT Version :9

• Sequence 1: NP_609384.1
• Gene: CG5022 / 34398
• FlyBaseID: FBgn0032225
• Length: 572
• Species: Drosophila melanogaster
• Sequence 2: XP_024302117.1
• Gene: EPB41L2 / 2037
• HGNCID: 3379
• Length: 1079
• Species: Homo sapiens
• Alignment Length: 558
• Identity: 160/558 - (28%)
• Similarity: 251/558 - (44%)
• Gaps: 90/558 - (16%)

  Fly    13 KCTVRLLDDSDVLECEFQPFHKGIYLLEYLCGELEIKEKDYFGLRYVDSSKQRHWLDLSKSIIKQ 77
            :|.|.|||.:: ..|:.:...||..|.:.:|..|.:.|||||||.:.:|.:|::|||.:|.|.:|
Human   219 QCKVTLLDGTE-YSCDLEKHAKGQVLFDKVCEHLNLLEKDYFGLLFQESPEQKNWLDPAKEIKRQ 282

  Fly    78 CKEMDPLLFSLRVKFYPADPFRLTGN-ARIMLYQQLKRDLRHGRLYCSLGEAAALGALIVQEELG 141
            .:.: |.||:..|||||.||.:||.: .|..|..||::|:..|||.||....|.||:..:|.|||
Human   283 LRNL-PWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLGSYTLQAELG 346

  Fly   142 DYNEDVHVGSYVSSIELALRQTECLEKKIIELHKKREPGQNLSLAMDEFLGIARGLETYGIDPHP 206
            ||:.:.|....:|..:.|..||:.||:|:.||||... |.:.:.|..:||..|:.|..||:|.|.
Human   347 DYDPEEHGSIDLSEFQFAPTQTKELEEKVAELHKTHR-GLSPAQADSQFLENAKRLSMYGVDLHH 410

  Fly   207 VKDHRGSQQYVGINNTGISTFVAGKRSQHFRWNEIHKINFEGKMFIAHLSYTDASREPKKHTVGF 271
            .||..|....:|:...|:..:....|...|.|.:|.||:::...|  ::....|..|..:.|:||
Human   411 AKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNF--YIKVRPAELEQFESTIGF 473

  Fly   272 KCPTGAACRYLWRCAIEQMLFFTLPNSQSAAVISGGGFFSWGTKFRYTGRTEREILTENINALRE 336
            |.|...|.:.||:..:|...|:.|.:.:......   |.:.|:||||:|||:.:  |...:.|.:
Human   474 KLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKAK---FLTLGSKFRYSGRTQAQ--TRQASTLID 533

  Fly   337 QKN---NSNSSKRKASSVPATPSSPQGDLAQIRYSSLPRSTMSEPLGYGMPNGHFYGHDHGM--- 395
            :..   ...||||.:.|:   ..:|.|.:.|......|.:.           |....:..|:
Human   534 RPAPHFERTSSKRVSRSL---DGAPIGVMDQSLMKDFPGAA-----------GEISAYGPGLVSI 584

  Fly   396 ---SDANGGIQISS------LEPVCEEARLRSSNIDGVNY------LASQIGGYAYRDSVEHSST 445
               .|.:|..::.|      |:.:  |.:..|..::|.|.      |..:....|..|.::|.::
Human   585 AVVQDGDGRREVRSPTKAPHLQLI--EGKKNSLRVEGDNIYVRHSNLMLEELDKAQEDILKHQAS 647

  Fly   446 ESGLTVNGYD---HPRKHN-EARQ--------HGSYSPNL------YYGQSD------------- 479
            .|.|..|..:   .||.:. |.|:        .||....:      ..|.||
Human   648 ISELKRNFMESTPEPRPNEWEKRRITPLSLQTQGSLEEEITSILFSEKGFSDSMKATFTSATTWT 712

  Fly   480 --GAVNSSSPADSFLHADPSTRKVKKFRKFHLLHAFVP 515
              |||.|::.....|.:.|.:         |||....|
Human   713 AEGAVVSANAPSEKLSSSPFS---------HLLETRAP 741

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5022	NP_609384.1	B41	13..205	CDD:214604	78/192 (41%)
		FERM_N	16..80	CDD:286467	25/63 (40%)
		FERM_M	108..205	CDD:278785	39/96 (41%)
		FERM_C_FRMD3_FRMD5	186..294	CDD:270013	33/107 (31%)
		FA	308..349	CDD:285894	15/43 (35%)
EPB41L2	XP_024302117.1	Neuromodulin_N	<9..222	CDD:331332	1/2 (50%)
		B41	220..409	CDD:214604	78/191 (41%)
		FERM_C_4_1_family	404..497	CDD:270005	28/94 (30%)
		FA	507..549	CDD:312314	15/46 (33%)
		SAB	630..673	CDD:309500	10/42 (24%)
		4_1_CTD	967..1072	CDD:310467

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151643
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740