Protein Alignment Frmd5 and frm-4

DIOPT Version :10

• Sequence 1: NP_609384.1
• Gene: Frmd5 / 34398
• FlyBaseID: FBgn0032225
• Length: 572
• Species: Drosophila melanogaster
• Sequence 2: NP_001249887.1
• Gene: frm-4 / 172189
• WormBaseID: WBGene00001491
• Length: 672
• Species: Caenorhabditis elegans
• Alignment Length: 670
• Identity: 183/670 - (27%)
• Similarity: 281/670 - (41%)
• Gaps: 151/670 - (22%)

  Fly    13 KCTVRLLDDSDVLECEFQPFHKGIYLLEYLCGELEIKEKDYFGLRYVDSSKQRHWLDLSKSI--- 74
            :|.|.||.|||::..||........:|:|:|....|:|||:.||||.|..|.|:||||::||
 Worm    29 RCNVHLLHDSDIIGNEFPRTQSAQTILDYVCQLKHIQEKDFLGLRYQDHHKHRYWLDLTRSINHV 93

  Fly    75 -------IKQCKEMDPLLFSLRVKFYPADPFRLTG-NARIMLYQQLKRDLRHGRLYCSLGEAAAL 131
                   ||:..:.:.:...||.::||:||.||.. |.|..|:.||:|||.||||||....||.|
 Worm    94 VKNFKKEIKKVGKTESMTLHLRFRYYPSDPARLRDPNLRYQLFVQLQRDLLHGRLYCPTSSAAEL 158

  Fly   132 GALIVQEELGDYNEDVHVGSYVSSIELALRQTECLEKKIIELHKKREPGQNLSLAMDEFLGIARG 196
            .|||:|.:||||||:.|||:|||..:|.|:||..||::|...||:.: |::...|..|||..|..
 Worm   159 AALILQAQLGDYNEEKHVGNYVSGYKLLLKQTPKLEERIANNHKELK-GKSSESAELEFLEKASQ 222

  Fly   197 LETYGIDPHPVKD-HRGSQQYVGINNTGISTFVAGKRSQHFRWNEIHKINFEGKMFIAHL----- 255
            |:||..||:.:|: |.....|:|.:..||..:....|:.:..|:|:.|:::.||.....|
 Worm   223 LDTYAFDPYTIKEPHDTLPVYIGASCKGILIYTGQSRTHNIDWSELVKVDYSGKEIRLTLSENYR 287

  Fly   256 ---------------------SYTDASREPKKHTVGFKCPTGAACRYLWRCAIEQMLFFTLPNSQ 299
                                 |..|.|...|..|:.:.||:|...::||...:.|..||...::|
 Worm   288 GQITAAGTPTGTLNGHGPGSPSIMDKSLTKKPLTLKYTCPSGQFAKHLWIHILSQQAFFNETSAQ 352

  Fly   300 SA---------AVISGGGFFSWGTKFRYTGRTEREILTEN------------INALREQKNNSNS 343
            ..         .::|.|..|.:.:|     |..|||..|:            .:|:..:...||.
 Worm   353 DVKLKFSKPRIPLLSRGSTFRFPSK-----RVYREIEEEDSKSILFDKSIMETSAVMNETTTSNE 412

  Fly   344 SKR---KASSVPATPSSPQGDLAQIRYSSL---PR---------------------STMSEPLGY 381
            ::.   ..|::.|..||..|   .:||..|   ||                     |:.|.|
 Worm   413 NEESILNCSTISAPLSSGSG---VVRYDLLRQTPRVEQPWLKQNSLKVTTVHDNTASSSSSP--- 471

  Fly   382 GMPNGHFYGHDHGMSDANGGIQISSLEPVCEEARLRSSNIDGVNYLASQIGGYAYRD-------- 438
                      |:..:..|...:|::|....|.....|.:...|..:.:|    .:.|
 Worm   472 ----------DNSETQNNNLSKITNLNLSIEREVSTSPSTSPVPIVHTQ----QHSDHNSTSFTV 522

  Fly   439 --------SVEHSSTESGLTVNGYDHPRKHNEARQHGSYSPNLYYGQSDGAVNSSS------PAD 489
                    :...|||.|..|.....:..|:...:........:..|:.....|.::      ..|
 Worm   523 HLIKREEVATSSSSTSSTTTTGQQQNLEKNGNGKLANGGGSGVDLGKKTVHTNGTTLICTEEKQD 587

  Fly   490 SFLHADPS-------TRKVKKFRKFHLLHAFVPSVIFVAFAMAGTAVFIMESESEAFEQLRNSPE 547
            |.|..|.|       :|.......|.|:...:.:::.|.|.         :||..|......|..
 Worm   588 SILSMDESLTSKSLISRIANTCFVFFLILLLIVAIVIVLFE---------KSEDSAHNDFIESHR 643

  Fly   548 MLC-LRYQYYQPLKEFVLEK 566
            .|. ||:.||:|.:.:|:|:
 Worm   644 ALSDLRHLYYEPTRHYVVEQ 663

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Frmd5	NP_609384.1	FERM_F1_FRMD3	12..93	CDD:340622	33/89 (37%)
		FERM_M	104..205	CDD:459788	51/100 (51%)
		FERM_C_FRMD3_FRMD5	186..294	CDD:270013	35/134 (26%)
		FA	308..350	CDD:462582	10/56 (18%)
frm-4	NP_001249887.1	B41	29..226	CDD:214604	88/197 (45%)
		PH-like	212..346	CDD:473070	34/133 (26%)