DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5022 and frm-4

DIOPT Version :9

Sequence 1:	NP_609384.1	Gene:	CG5022 / 34398	FlyBaseID:	FBgn0032225	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	NP_001249887.1	Gene:	frm-4 / 172189	WormBaseID:	WBGene00001491	Length:	672	Species:	Caenorhabditis elegans

Alignment Length:	670	Identity:	183/670 - (27%)
Similarity:	281/670 - (41%)	Gaps:	151/670 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 KCTVRLLDDSDVLECEFQPFHKGIYLLEYLCGELEIKEKDYFGLRYVDSSKQRHWLDLSKSI--- 74
            :|.|.||.|||::..||........:|:|:|....|:|||:.||||.|..|.|:||||::||
Worm    29 RCNVHLLHDSDIIGNEFPRTQSAQTILDYVCQLKHIQEKDFLGLRYQDHHKHRYWLDLTRSINHV 93

  Fly    75 -------IKQCKEMDPLLFSLRVKFYPADPFRLTG-NARIMLYQQLKRDLRHGRLYCSLGEAAAL 131
                   ||:..:.:.:...||.::||:||.||.. |.|..|:.||:|||.||||||....||.|
Worm    94 VKNFKKEIKKVGKTESMTLHLRFRYYPSDPARLRDPNLRYQLFVQLQRDLLHGRLYCPTSSAAEL 158

  Fly   132 GALIVQEELGDYNEDVHVGSYVSSIELALRQTECLEKKIIELHKKREPGQNLSLAMDEFLGIARG 196
            .|||:|.:||||||:.|||:|||..:|.|:||..||::|...||:.: |::...|..|||..|..
Worm   159 AALILQAQLGDYNEEKHVGNYVSGYKLLLKQTPKLEERIANNHKELK-GKSSESAELEFLEKASQ 222

  Fly   197 LETYGIDPHPVKD-HRGSQQYVGINNTGISTFVAGKRSQHFRWNEIHKINFEGKMFIAHL----- 255
            |:||..||:.:|: |.....|:|.:..||..:....|:.:..|:|:.|:::.||.....|
Worm   223 LDTYAFDPYTIKEPHDTLPVYIGASCKGILIYTGQSRTHNIDWSELVKVDYSGKEIRLTLSENYR 287

  Fly   256 ---------------------SYTDASREPKKHTVGFKCPTGAACRYLWRCAIEQMLFFTLPNSQ 299
                                 |..|.|...|..|:.:.||:|...::||...:.|..||...::|
Worm   288 GQITAAGTPTGTLNGHGPGSPSIMDKSLTKKPLTLKYTCPSGQFAKHLWIHILSQQAFFNETSAQ 352

  Fly   300 SA---------AVISGGGFFSWGTKFRYTGRTEREILTEN------------INALREQKNNSNS 343
            ..         .::|.|..|.:.:|     |..|||..|:            .:|:..:...||.
Worm   353 DVKLKFSKPRIPLLSRGSTFRFPSK-----RVYREIEEEDSKSILFDKSIMETSAVMNETTTSNE 412

  Fly   344 SKR---KASSVPATPSSPQGDLAQIRYSSL---PR---------------------STMSEPLGY 381
            ::.   ..|::.|..||..|   .:||..|   ||                     |:.|.|
Worm   413 NEESILNCSTISAPLSSGSG---VVRYDLLRQTPRVEQPWLKQNSLKVTTVHDNTASSSSSP--- 471

  Fly   382 GMPNGHFYGHDHGMSDANGGIQISSLEPVCEEARLRSSNIDGVNYLASQIGGYAYRD-------- 438
                      |:..:..|...:|::|....|.....|.:...|..:.:|    .:.|
Worm   472 ----------DNSETQNNNLSKITNLNLSIEREVSTSPSTSPVPIVHTQ----QHSDHNSTSFTV 522

  Fly   439 --------SVEHSSTESGLTVNGYDHPRKHNEARQHGSYSPNLYYGQSDGAVNSSS------PAD 489
                    :...|||.|..|.....:..|:...:........:..|:.....|.::      ..|
Worm   523 HLIKREEVATSSSSTSSTTTTGQQQNLEKNGNGKLANGGGSGVDLGKKTVHTNGTTLICTEEKQD 587

  Fly   490 SFLHADPS-------TRKVKKFRKFHLLHAFVPSVIFVAFAMAGTAVFIMESESEAFEQLRNSPE 547
            |.|..|.|       :|.......|.|:...:.:::.|.|.         :||..|......|..
Worm   588 SILSMDESLTSKSLISRIANTCFVFFLILLLIVAIVIVLFE---------KSEDSAHNDFIESHR 643

  Fly   548 MLC-LRYQYYQPLKEFVLEK 566
            .|. ||:.||:|.:.:|:|:
Worm   644 ALSDLRHLYYEPTRHYVVEQ 663

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5022	NP_609384.1	B41	13..205	CDD:214604	91/202 (45%)
		FERM_N	16..80	CDD:286467	30/73 (41%)
		FERM_M	108..205	CDD:278785	50/96 (52%)
		FERM_C_FRMD3_FRMD5	186..294	CDD:270013	35/134 (26%)
		FA	308..349	CDD:285894	10/55 (18%)
frm-4	NP_001249887.1	B41	29..226	CDD:214604	88/197 (45%)
frm-4	NP_001249887.1	PH-like	212..346	CDD:388408	34/133 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162252
Domainoid	1	1.000	49	1.000	Domainoid score	I7996
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	204	1.000	Inparanoid score	I2449
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002996
OrthoInspector	1	1.000	-	-		oto19472
orthoMCL	1	0.900	-	-		OOG6_105621
Panther	1	1.100	-	-	LDO	PTHR23280
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R7059
SonicParanoid	1	1.000	-	-		X1988
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.920