DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5022 and Epb41l2

DIOPT Version :9

Sequence 1:	NP_609384.1	Gene:	CG5022 / 34398	FlyBaseID:	FBgn0032225	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	XP_006512569.1	Gene:	Epb41l2 / 13822	MGIID:	103009	Length:	1062	Species:	Mus musculus

Alignment Length:	431	Identity:	133/431 - (30%)
Similarity:	212/431 - (49%)	Gaps:	40/431 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 SKNEGNIVYKCTVRLLDDSDVLECEFQPFHKGIYLLEYLCGELEIKEKDYFGLRYVDSSKQRHWL 68
            :|....::.|.|  |||.:: ..|:.:...||..|.:.:|..|.:.|||||||.:.|..:|::||
Mouse   205 TKKTKTVLAKVT--LLDGTE-YSCDLEKRAKGQVLFDRVCEHLNLLEKDYFGLLFQDHPEQKNWL 266

  Fly    69 DLSKSIIKQCKEMDPLLFSLRVKFYPADPFRLTGN-ARIMLYQQLKRDLRHGRLYCSLGEAAALG 132
            |.:|.|.:|.|.: |.||:..|||||.||.:||.: .|..|..||::|:..|||.||....|.||
Mouse   267 DPAKEIKRQLKNL-PWLFTFNVKFYPPDPSQLTEDITRYFLCLQLRQDIASGRLPCSFVTHALLG 330

  Fly   133 ALIVQEELGDYNEDVHVGSYVSSIELALRQTECLEKKIIELHKKREPGQNLSLAMDEFLGIARGL 197
            :..:|.|.|||:.:.:....:...:.|...|:.||:|:.||||... |.:.:.|..:||..|:.|
Mouse   331 SYTLQAEHGDYDPEEYDSIDLGDFQFAPAHTKELEEKVSELHKTHR-GLSPAQADSQFLENAKRL 394

  Fly   198 ETYGIDPHPVKDHRGSQQYVGINNTGISTFVAGKRSQHFRWNEIHKINFEGKMFIAHLSYTDASR 262
            ..||:|.|..||..|....:|:...|:..:....|...|.|.:|.||:::...|  ::....|..
Mouse   395 SMYGVDLHHAKDSEGVDIKLGVCANGLLIYKDRLRINRFAWPKILKISYKRSNF--YIKVRPAEL 457

  Fly   263 EPKKHTVGFKCPTGAACRYLWRCAIEQMLFFTLPNSQSAAVISGGGFFSWGTKFRYTGRTEREIL 327
            |..:.|:|||.|...|.:.||:..:|...|:.|.:.:......   |.:.|:||||:|||:.:
Mouse   458 EQFESTIGFKLPNHRAAKRLWKVCVEHHTFYRLVSPEQPPKTK---FLTLGSKFRYSGRTQAQ-- 517

  Fly   328 TENINALREQ---KNNSNSSKRKASSVPATP-----SSPQGDLAQIRYSSLPRSTMSEPLGYGMP 384
            |...:.|.::   :....||||.:.|:...|     .||.|:      .|:|        |.|:.
Mouse   518 TREASTLIDRPAPQFERASSKRVSRSLDGAPIGVVDQSPPGE------GSVP--------GPGVI 568

  Fly   385 NGHFYGHDHGMSDANGGIQISSLEPVCEEARLRSSNIDGVN 425
            :  :.....|..|:....:.:   |:..|.:..:..:||.|
Mouse   569 S--YTTIQDGRRDSKSPTKAT---PLPAEGKKNTLRVDGDN 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5022	NP_609384.1	B41	13..205	CDD:214604	75/192 (39%)
		FERM_N	16..80	CDD:286467	24/63 (38%)
		FERM_M	108..205	CDD:278785	35/96 (36%)
		FERM_C_FRMD3_FRMD5	186..294	CDD:270013	33/107 (31%)
		FA	308..349	CDD:285894	15/43 (35%)
Epb41l2	XP_006512569.1	PTZ00121	<4..209	CDD:173412	1/3 (33%)
		B41	213..402	CDD:214604	75/193 (39%)
		FERM_C_4_1_family	397..490	CDD:270005	28/94 (30%)
		FA	500..543	CDD:400882	15/47 (32%)
		SAB	613..653	CDD:398195
		PHA03247	<642..745	CDD:223021
		4_1_CTD	950..1052	CDD:399118
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167841761
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740