DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5022 and epb41l4b

DIOPT Version :9

Sequence 1:	NP_609384.1	Gene:	CG5022 / 34398	FlyBaseID:	FBgn0032225	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	XP_005158090.1	Gene:	epb41l4b / 100332627	ZFINID:	ZDB-GENE-100921-92	Length:	729	Species:	Danio rerio

Alignment Length:	381	Identity:	119/381 - (31%)
Similarity:	175/381 - (45%)	Gaps:	39/381 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 CTVRLLDDSDVLECEFQPFHKGIYLLEYLCGELEIKEKDYFGLRYVDSSKQRHWLDLSKSIIKQC 78
            |.|.|||.||| ..|.....||..|.:.:...|::.|.|||||:::|..:..||||.:|.|.||.
Zfish    70 CRVLLLDGSDV-NVELPKHAKGQDLFDQIMYHLDLVEADYFGLQFMDPEQVAHWLDAAKPIKKQI 133

  Fly    79 KEMDPLLFSLRVKFYPADPFRLTGN-ARIMLYQQLKRDLRHGRLYCSLGEAAALGALIVQEELGD 142
            :...|.....|||||.::|..|... .|.:...||::|:..|:|.|....:..|||..:|.||||
Zfish   134 RHGPPYRLFFRVKFYSSEPNNLHEEFTRYLFVLQLRQDILSGKLKCPYDVSVELGAYCLQSELGD 198

  Fly   143 YNEDVHVGSYVSSIELALRQTECLE----KKIIELHKKREPGQNLSLAMDEFLGIARGLETYGID 203
            .:...|....||....:.:|||.:|    :|.:|..     |...|.|...||...:.||.||:|
Zfish   199 CDPLEHSILLVSEFRFSPKQTEIMEADIYRKWVECR-----GMIPSQAELNFLNKCKWLEMYGVD 258

  Fly   204 PHPVKDHRGSQQYVGINNTGISTFVAGKRSQHFRWNEIHKINFEGKMFIAHLSYTDASREPKKHT 268
            .|.||...|.:..:|:..|||..|....:...|.|.:|.:::|:.......:...|.....::||
Zfish   259 MHFVKGRDGGEYALGLTPTGILVFEGSSKIGLFFWPKITRLDFKRNRLTLVVVEDDEKGREQEHT 323

  Fly   269 VGFKCPTGAACRYLWRCAIEQMLFFTL--PNSQSAAVISGGGFFSWGTKFRYTGRTEREILTENI 331
            ..|:..:...|::||:||:|...||.|  |.....   |...|...|::||::||||.:.
Zfish   324 FVFQLSSSHECKHLWKCAVESHAFFRLRQPTHNKT---SRSDFTRLGSRFRFSGRTEYQA----- 380

  Fly   332 NALREQKNNSNSSK-RKASSVPATPSSPQGDLAQ--------IRYSSLPRSTMSEP 378
                     ::|.| |:||:....||......||        .::..|...|..||
Zfish   381 ---------THSGKVRRASTFERRPSKRYPSRAQSMVKAMTPAKHPHLSAQTSPEP 427

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5022	NP_609384.1	B41	13..205	CDD:214604	70/195 (36%)
		FERM_N	16..80	CDD:286467	27/63 (43%)
		FERM_M	108..205	CDD:278785	33/100 (33%)
		FERM_C_FRMD3_FRMD5	186..294	CDD:270013	32/107 (30%)
		FA	308..349	CDD:285894	11/41 (27%)
epb41l4b	XP_005158090.1	B41	69..260	CDD:214604	70/195 (36%)
		FERM_N	72..134	CDD:286467	27/62 (44%)
		FERM_M	153..260	CDD:278785	35/111 (32%)
		FERM_C_NBL4_NBL5	256..349	CDD:270007	26/92 (28%)
		FA	362..402	CDD:285894	15/53 (28%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170586150
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3530
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.740