DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5022 and frmd3

DIOPT Version :9

Sequence 1:	NP_609384.1	Gene:	CG5022 / 34398	FlyBaseID:	FBgn0032225	Length:	572	Species:	Drosophila melanogaster
Sequence 2:	XP_002663277.2	Gene:	frmd3 / 100331256	ZFINID:	ZDB-GENE-070523-1	Length:	603	Species:	Danio rerio

Alignment Length:	625	Identity:	197/625 - (31%)
Similarity:	288/625 - (46%)	Gaps:	97/625 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 FRSKNEGNIV--YKCTVRLLDDSDVLECEFQPFHKGIYLLEYLCGELEIKEKDYFGLRYVDSSKQ 64
            |||.:..::.  .:|||||||||:: .|..|...||.:|::::|....:.||||||:||||..||
Zfish     6 FRSPSLSSLALELQCTVRLLDDSEI-SCSIQRDTKGQFLVDHVCNHYSLLEKDYFGIRYVDPDKQ 69

  Fly    65 RHWLDLSKSIIKQCKEMDPLLFSLRVKFYPADPFRLTGN-ARIMLYQQLKRDLRHGRLYCSLGEA 128
            |||||.||.::||.|...|.....||||||.:|.::... .|.:||.|||||:.||||.|...:|
Zfish    70 RHWLDPSKPVVKQMKCQQPYTMCFRVKFYPQEPIKIKEELTRYLLYLQLKRDVYHGRLLCPFADA 134

  Fly   129 AALGALIVQEELGDYNEDVHVGSYVSSIELALRQTECLEKKIIELHKKREPGQNLSLAMDEFLGI 193
            |.|||.|||.|||||:.:.|...|:|..:|..:|:..||:||:|:|:....||..|||....|..
Zfish   135 AYLGACIVQAELGDYDPEEHPADYISDFKLFPKQSLKLERKIMEIHQNELRGQCPSLAELNLLQR 199

  Fly   194 ARGLETYGIDPHPVKDHRGSQQYVGINNTGISTFVAGKRSQHFRWNEIHKINFEGKMFIAHLSYT 258
            |..|:|||:||||.||..||..::|....|...|...||....:|.::.|..||||.|     |.
Zfish   200 AHTLDTYGVDPHPCKDFTGSTAFLGFTARGFVVFQGNKRIHLLKWADVSKFKFEGKTF-----YV 259

  Fly   259 DASREPKKHTVGFKCPTGAACRYLWRCAIEQMLFFTLPNSQSAAVISGGGFFSWGTKFRYTGRTE 323
            ...:..||..:.|...|.|||::||:|.:|...|:....|.....:|....|..|::|||:||..
Zfish   260 IGVQREKKLVLTFHTSTPAACKHLWKCGVENQAFYKCAKSSQIKTVSSSSIFFKGSRFRYSGRVA 324

  Fly   324 REILTENINALRE----------QKNNSNSSKRKASSVPATPSSPQGDLAQIRYSSLPRSTMSEP 378
            :|::..:....|:          |..:..|...|...:...|..|.  |:..|.|   |.:.:
Zfish   325 KEVIEASSKIQRDPPVVHRCQFGQSRSFTSLSHKQLIMNMEPLLPA--LSSSRES---RDSSA-- 382

  Fly   379 LGYGMPNGHFYGHDHGMSDANGGIQISSLEP--VCEEARLRSSNIDGVNYL-------ASQIGGY 434
                         |:|:|.....:.:|.|:|  ..|||.:.    :.:|:.       |||
Zfish   383 -------------DNGLSALKDCVHLSPLKPSVTPEEAEME----EMLNFSQERREDEASQ---- 426

  Fly   435 AYRDSVEHSSTESGLTVNGYDHPRKHNEARQHGSYSP-------NLYYGQSDGAVNSSSPADSF- 491
              |..|:....|  :.|:..|............:|||       .:...|....:...|||...
Zfish   427 --RTRVDEDRRE--IHVDSEDDTSGGAHTISDTAYSPCASLVPTPVEEAQGGLELLFQSPARLLK 487

  Fly   492 -LHADPSTRKV-----------KKFRKF--------HLLHAFVPSVIFVAFAMAGTAVF------ 530
             |||||..::.           :.||:.        ..:.|.:.|...:.....|..:.
Zfish   488 ELHADPDMQRELQAERQREAEREAFRQSLCSPSSGRQQMQACLRSAARLVLMATGLLMILLPLLL 552

  Fly   531 -IMESESEA--FEQLRNSPEMLCLRYQYYQPLKEFVLEKL 567
             ::||:.:.  ...:|.:||.....|:||.||:.:.|.||
Zfish   553 VLLESDLDISFLHDIRQTPEFEQFHYEYYCPLRRWFLCKL 592

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5022	NP_609384.1	B41	13..205	CDD:214604	94/192 (49%)
		FERM_N	16..80	CDD:286467	34/63 (54%)
		FERM_M	108..205	CDD:278785	48/96 (50%)
		FERM_C_FRMD3_FRMD5	186..294	CDD:270013	40/107 (37%)
		FA	308..349	CDD:285894	12/50 (24%)
frmd3	XP_002663277.2	B41	20..211	CDD:214604	94/191 (49%)
		FERM_N	22..85	CDD:286467	34/63 (54%)
		FERM_M	104..211	CDD:278785	49/106 (46%)
		PH-like	192..295	CDD:302622	40/107 (37%)
		FA	310..356	CDD:285894	11/45 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	77	1.000	Domainoid score	I8774
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D227685at33208
OrthoFinder	1	1.000	-	-		FOG0002996
OrthoInspector	1	1.000	-	-		otm25643
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1988
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	6	5.920