Protein Alignment Sps2 and SEPHS1

DIOPT Version :10

• Sequence 1: NP_477478.4
• Gene: Sps2 / 34397
• FlyBaseID: FBgn0032224
• Length: 370
• Species: Drosophila melanogaster
• Sequence 2: NP_036379.2
• Gene: SEPHS1 / 22929
• HGNCID: 19685
• Length: 392
• Species: Homo sapiens
• Alignment Length: 376
• Identity: 160/376 - (42%)
• Similarity: 234/376 - (62%)
• Gaps: 14/376 - (3%)

  Fly     2 FQPEKHGLEPDFQLTKFTTHTGUSCKIPQKVLEKYLRGTEIENKNNDGYLIGS-------GMDCA 59
            |.||.:.|:..|:||:||...|..||:||.||:|.|...:..:...|...:|:       |||..
Human     7 FNPESYELDKSFRLTRFTELKGTGCKVPQDVLQKLLESLQENHFQEDEQFLGAVMPRLGIGMDTC 71

  Fly    60 VIPLKRHKDYLLIQTVDFFYPMVNDPELLGRIALANVLSDVYAVGVTQFDTVEMIVSTSTSFSEK 124
            |||| ||....|:||.|:.||:|:||.::||||.||||||:||:|||:.|.:.|::..|...:::
Human    72 VIPL-RHGGLSLVQTTDYIYPIVDDPYMMGRIACANVLSDLYAMGVTECDNMLMLLGVSNKMTDR 135

  Fly   125 ERDVVIGLVMKGFQNSLKANGYRNTPLIIRQLKINPWCIIGGIATSVCRSEEIILPSNAQPGDVL 189
            |||.|:.|:::||:::.:..|   |.:...|..:|||.::||:||:||:..|.|:|.||.|||||
Human   136 ERDKVMPLIIQGFKDAAEEAG---TSVTGGQTVLNPWIVLGGVATTVCQPNEFIMPDNAVPGDVL 197

  Fly   190 VLTKPLGGQMAMDAHLWQLNQTEKYKKLLSECSDADIKETFEIAVKSMTYLNKNAALLMHKYQAH 254
            |||||||.|:|:..|.| |:..||:.|:....:..|::..::.|:.:|..||:.||.|||.:.||
Human   198 VLTKPLGTQVAVAVHQW-LDIPEKWNKIKLVVTQEDVELAYQEAMMNMARLNRTAAGLMHTFNAH 261

  Fly   255 CATDITGFGLLGHANNLAQFQKEKVLFQINKLPIIKNVLKFSTLVGQSTKFRSGRSVETSGGLLI 319
            .||||||||:||||.|||:.|:.:|.|.|:.||::..:...|...|.......|...||||||||
Human   262 AATDITGFGILGHAQNLAKQQRNEVSFVIHNLPVLAKMAAVSKACGNMFGLMHGTCPETSGGLLI 326

  Fly   320 CLPADAADKFCRDFEEATNGE-QKSFQIGHVTAANESDAVLCEDVEFIEVS 369
            |||.:.|.:||.:.:....|| .:::.||.|...|.: |.:.:....|||:
Human   327 CLPREQAARFCAEIKSPKYGEGHQAWIIGIVEKGNRT-ARIIDKPRIIEVA 376

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Sps2	NP_477478.4	SelD	15..349	CDD:100031	149/341 (44%)
SEPHS1	NP_036379.2	selD	19..333	CDD:273100	142/318 (45%)