DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GATAd and gata2b

DIOPT Version :9

Sequence 1:	NP_001260326.1	Gene:	GATAd / 34395	FlyBaseID:	FBgn0032223	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	XP_009300818.1	Gene:	gata2b / 436962	ZFINID:	ZDB-GENE-040718-440	Length:	428	Species:	Danio rerio

Alignment Length:	362	Identity:	94/362 - (25%)
Similarity:	144/362 - (39%)	Gaps:	84/362 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   459 DGVEIDLS-VKKQKNDYSNQRNAAPIHHFCQT--------------------PMLDIQSHLRSEE 502
            |.|::.|| :..|.|.|.:...:.....:.||                    |:||     .|:.
Zfish    50 DEVDVFLSHLDSQGNPYYHTHGSRARMSYSQTHARLTGGSMCRPHLINTHGLPLLD-----NSKS 109

  Fly   503 DF---QNY-SITINQVGGSDFKSKAPKASTGSLLDSGDSSDSHKLEMDITSSINDRK--TPDSLS 561
            .|   |:: |.|::.:|.:...|...::|.|....:|..:......:.:|...:.:.  .|.:..
Zfish   110 TFSTAQHHGSWTVSHLGKAVLHSAGAESSNGLYAGTGAPASGPMPCLSMTQHCSAQLYCLPPTPP 174

  Fly   562 SDHATDAATTQLWQALARSAAK-------SKEDNPASQIFRNMMSQPFAFPVPS--TVSFTKVPE 617
            .|.:.|.|.     |..|.|.|       ..:...:|.|..|........|:||  ..|.....|
Zfish   175 KDVSPDPAC-----AAVRDAGKYHLHLVDGMKMECSSPIRSNPHLAQTTTPIPSYPDYSVAGAHE 234

  Fly   618 EPIALLKDLSEAQSSKSKPCRRKQSFPTKTDCIDVVNENVTDTYTTSEATPDDKKDKRNINLFNA 682
            .|.::....:...:..:| |:.|....:..:|   ||...|       :||..::|.....|.||
Zfish   235 YPASVFHSRNLLGNMTTK-CKSKNRAFSGREC---VNCGAT-------STPLWRRDGTGHYLCNA 288

  Fly   683 ------IPGAQKDM---------------SCSNCGTLTTTIWRRSVRGEMVCNACGLYFKLHGVN 726
                  :.|..:.:               .|:||.|.|||:|||:..||.||||||||:|||.||
Zfish   289 CGLYHKMNGQNRPLIRPKRRLSASRRAGTCCANCQTGTTTLWRRNANGEPVCNACGLYYKLHNVN 353

  Fly   727 RPHSMRRDTIHTRRRRPKELERSKKKH----KQMSSC 759
            ||.:|::|.|.||.|  |...:|||:.    .|..||
Zfish   354 RPLTMKKDGIQTRNR--KMSGKSKKRRGEHFHQFDSC 388

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GATAd	NP_001260326.1	zf-AD	<228..284	CDD:214871
		ZnF_GATA	688..736	CDD:214648	29/62 (47%)
		ZnF_GATA	691..742	CDD:238123	32/50 (64%)
gata2b	XP_009300818.1	ZnF_GATA	261..308	CDD:214648	11/56 (20%)
		ZnF_GATA	264..314	CDD:238123	11/59 (19%)
		ZnF_GATA	314..363	CDD:214648	29/48 (60%)
		ZnF_GATA	319..369	CDD:238123	33/51 (65%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170573866
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	4	3.740