DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment GATAd and grn

DIOPT Version :9

Sequence 1:	NP_001260326.1	Gene:	GATAd / 34395	FlyBaseID:	FBgn0032223	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_001262366.1	Gene:	grn / 40962	FlyBaseID:	FBgn0001138	Length:	712	Species:	Drosophila melanogaster

Alignment Length:	703	Identity:	137/703 - (19%)
Similarity:	214/703 - (30%)	Gaps:	249/703 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 HHHQNQTKIH-YTPSVPSAADAKSSERERQCQLESDIAERSTVFKSQSSSDHEHI--------EY 168
            ||.:.....| :|..:|                       ||....|....|.|.        |:
  Fly    96 HHRRYYPSYHQHTSRMP-----------------------STHASPQVCRPHFHTPLSPWLTSEH 137

  Fly   169 SGETPSPSASLSQSQTKSEPMREEEEHQHNHNQQSGREETSVNTTNISGTDNYGKEHGRDDSSSP 233
            ....|:.:.|:.|.....||..|.:..|...:.|          |..:|      :|......:|
  Fly   138 KSFAPASAWSMGQFACPQEPQVEHKLGQMGQSHQ----------TTAAG------QHSFPFPPTP 186

  Fly   234 HLTFQIFNCLSIKALPNDGLPNVVCGDCRQKLDSFEKFRTMAHNSQIALKEFLNISKNLRPDPND 298
                           |.|..|:                                   :::..|::
  Fly   187 ---------------PKDSTPD-----------------------------------SVQTGPSE 201

  Fly   299 LETKLDAILKASSEAIAAKALTELSTFSKVKYDHSKLDSSIQPGLDRKIEISNQEMPAHSLYPSL 363
            .:..::|.:  ..:|..:.:||:.|.                 .||.|..|.|......|...:.
  Fly   202 YQAVMNAFM--HQQATGSTSLTDASC-----------------ALDIKPSIQNGSASGSSGSGTT 247

  Fly   364 FKSITMKSDQKSKAMSGSSHSQFDSKLQKDSDIEKYENLQQQLETAAVLMDISKKIVISPPCSNP 428
            ..|...:.:..:...:.||:|....:.|:....::.:..|....|.|              .||.
  Fly   248 HTSTPKQREGTASTTNSSSNSSSSQQQQQQQQQQQQQQQQSSSNTTA--------------SSNT 298

  Fly   429 QSPCFSAAVDTSIKSSVIKSKRPSNQNEIQDGVE--------------------IDLSVKKQKND 473
            .:.  |:|...|:.::|..|...|: |.:.||..                    .|.|      .
  Fly   299 SAS--SSAAAASLSAAVAASAATSS-NGLFDGTAQAYSSGGSGGGGGGGSGSGGYDTS------S 354

  Fly   474 YSNQRNAAPIHHFCQTPMLDIQSHLRSEEDFQNYSITINQVGGSDFKSKA----PKASTGSLLDS 534
            |::..:||..|........::         ||:.|:....|..|...::|    ....:|. ..|
  Fly   355 YASYHHAAAHHQAAAVAAANM---------FQSSSVAAAAVRHSMAAAQAHHHHHHHHSGH-HHS 409

  Fly   535 GDSSDSHKLEMDITSSINDRKTPDSLSSDHATDAATTQLWQALARSAAKSKEDNPASQIFRNMMS 599
            |.||..|.|    ..|:.......|:|.:.....:.:      ..|.|.|...:....:
  Fly   410 GSSSGLHGL----GGSVGGTAGMGSMSGNSGGAGSLS------GHSGAGSNAGSNCLDV------ 458

  Fly   600 QPFAFPVPSTVSFTKVPEEPIALLKDLSEAQSSKSKPCRRKQSFPTKTDCIDVVNENVTDT---- 660
                                               ||.|.|..  |..:..:.||...|.|
  Fly   459 -----------------------------------KPVRTKPR--TSAEGRECVNCGATSTPLWR 486

  Fly   661 ---------------YTTSEATPDDKKDKRNINLFNAIPGAQK-DMSCSNCGTLTTTIWRRSVRG 709
                           |..:.......|.||.:.|.:....|:: ..||:||.|.|||:|||:..|
  Fly   487 RDGTGHYLCNACGLYYKMNGQNRPLIKPKRRLTLQSLQSAAKRAGTSCANCKTTTTTLWRRNASG 551

  Fly   710 EMVCNACGLYFKLHGVNRPHSMRRDTIHTRRRRPKELERSKKKHKQMSSCSSI 762
            |.||||||||:|||.||||.:|:::.|.||.|  |...:||||......|..|
  Fly   552 EPVCNACGLYYKLHNVNRPLTMKKEGIQTRNR--KLSSKSKKKKGLGGGCLPI 602

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GATAd	NP_001260326.1	zf-AD	<228..284	CDD:214871	4/55 (7%)
		ZnF_GATA	688..736	CDD:214648	29/48 (60%)
		ZnF_GATA	691..742	CDD:238123	32/50 (64%)
grn	NP_001262366.1	ZnF_GATA	470..517	CDD:214648	7/46 (15%)
		ZnF_GATA	473..517	CDD:238123	7/43 (16%)
		ZnF_GATA	529..578	CDD:214648	29/48 (60%)
		ZnF_GATA	533..583	CDD:238123	32/49 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45438454
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5641
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	1	1.000	-	-		mtm9213
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR10071
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	6	5.840