DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GATAd and GATA6

DIOPT Version :9

Sequence 1:	NP_001260326.1	Gene:	GATAd / 34395	FlyBaseID:	FBgn0032223	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_005248.2	Gene:	GATA6 / 2627	HGNCID:	4174	Length:	595	Species:	Homo sapiens

Alignment Length:	172	Identity:	65/172 - (37%)
Similarity:	89/172 - (51%)	Gaps:	31/172 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   601 PFAFPVPSTVSF-----TKVPEEPIA-LLKDLSEAQSSKSKPCRRKQSFPT---KTDCIDVVNEN 656
            ||..||..::..     ..||..|.| ||:||||     |:.|....|..|   :.|.......|
Human   353 PFETPVLHSLQSRAGAPLPVPRGPSADLLEDLSE-----SRECVNCGSIQTPLWRRDGTGHYLCN 412

  Fly   657 VTDTYTTSE--ATPDDKKDKRNINLFNAIPGAQK-DMSCSNCGTLTTTIWRRSVRGEMVCNACGL 718
            ....|:...  :.|..|..||       :|.::: .:||:||.|.|||:|||:..||.|||||||
Human   413 ACGLYSKMNGLSRPLIKPQKR-------VPSSRRLGLSCANCHTTTTTLWRRNAEGEPVCNACGL 470

  Fly   719 YFKLHGVNRPHSMRRDTIHTRRRRPKELERSKKKHKQMSSCS 760
            |.|||||.||.:|:::.|.||:|:||.:.:||       :||
Human   471 YMKLHGVPRPLAMKKEGIQTRKRKPKNINKSK-------TCS 505

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GATAd	NP_001260326.1	zf-AD	<228..284	CDD:214871
		ZnF_GATA	688..736	CDD:214648	29/48 (60%)
		ZnF_GATA	691..742	CDD:238123	32/50 (64%)
GATA6	NP_005248.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	14..71
		GATA-N	147..377	CDD:283099	6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	208..255
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	286..339
		ZnF_GATA	388..435	CDD:214648	10/53 (19%)
		ZnF_GATA	389..434	CDD:238123	10/51 (20%)
		ZnF_GATA	441..488	CDD:214648	29/46 (63%)
		ZnF_GATA	443..494	CDD:238123	32/50 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	482..561		11/31 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140998
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10071
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.840