DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GATAd and GATA2

DIOPT Version :9

Sequence 1:	NP_001260326.1	Gene:	GATAd / 34395	FlyBaseID:	FBgn0032223	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_001139133.1	Gene:	GATA2 / 2624	HGNCID:	4171	Length:	480	Species:	Homo sapiens

Alignment Length:	433	Identity:	103/433 - (23%)
Similarity:	149/433 - (34%)	Gaps:	150/433 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly   479 NAAPIHH--------FCQTPMLDIQSHLRSEEDFQNYSITINQVGGSDFKSKAPKASTGSLLDSG 535
            :||..||        |.:||:               :.......||.  .|..|.|..||...||
Human   106 SAAAAHHHNPWTVSPFSKTPL---------------HPSAAGGPGGP--LSVYPGAGGGSGGGSG 153

  Fly   536 DS----------SDSHKLEMDITSSINDRKTPDSLSSDHATDAATTQLWQALARSAA-------- 582
            .|          |.||......|       .|..:|.|.:|..|.:....:...|||
Human   154 SSVASLTPTAAHSGSHLFGFPPT-------PPKEVSPDPSTTGAASPASSSAGGSAARGEDKDGV 211

  Fly   583 ----------KSKEDNPASQIFRNMMSQPFA-FPVPSTVSFTKVPEEPIALLKDLSEA------- 629
                      |.:..:|.......|.:||.. .|:|:..|:  ||    |...|.|..
Human   212 KYQVSLTESMKMESGSPLRPGLATMGTQPATHHPIPTYPSY--VP----AAAHDYSSGLFHPGGF 270

  Fly   630 -----------QSSKSKPCRRKQSFPTKTDCIDVVNENVTDTYTTSEATPDDKKDKRNINLFNA- 682
                       |.||::.|...:      :|   ||...|       |||..::|.....|.||
Human   271 LGGPASSFTPKQRSKARSCSEGR------EC---VNCGAT-------ATPLWRRDGTGHYLCNAC 319

  Fly   683 -----IPGAQKDM---------------SCSNCGTLTTTIWRRSVRGEMVCNACGLYFKLHGVNR 727
                 :.|..:.:               .|:||.|.|||:|||:..|:.||||||||:|||.|||
Human   320 GLYHKMNGQNRPLIKPKRRLSAARRAGTCCANCQTTTTTLWRRNANGDPVCNACGLYYKLHNVNR 384

  Fly   728 PHSMRRDTIHTRRRRPKELERSKKKHKQMSSCSSIETTKQDFLTARESLAISGLVLNKFKKEIDD 792
            |.:|:::.|.||.|:   :....||.|:.:.|                       ..:..|.:.:
Human   385 PLTMKKEGIQTRNRK---MSNKSKKSKKGAEC-----------------------FEELSKCMQE 423

  Fly   793 TETPAAAALKDILSRRKKSNSLPAFNDTCESADLSAPLNLVSS 835
            ..:|.:||.  :.........||.|:.:........|::..||
Human   424 KSSPFSAAA--LAGHMAPVGHLPPFSHSGHILPTPTPIHPSSS 464

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GATAd	NP_001260326.1	zf-AD	<228..284	CDD:214871
		ZnF_GATA	688..736	CDD:214648	27/62 (44%)
		ZnF_GATA	691..742	CDD:238123	30/50 (60%)
GATA2	NP_001139133.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	119..209		25/113 (22%)
		ZnF_GATA	294..344	CDD:238123	12/59 (20%)
		ZnF_GATA	349..398	CDD:238123	30/48 (63%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	448..480		3/17 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165140993
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740