DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GATAd and Gata1

DIOPT Version :9

Sequence 1:	NP_001260326.1	Gene:	GATAd / 34395	FlyBaseID:	FBgn0032223	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_036896.1	Gene:	Gata1 / 25172	RGDID:	2663	Length:	413	Species:	Rattus norvegicus

Alignment Length:	323	Identity:	88/323 - (27%)
Similarity:	118/323 - (36%)	Gaps:	108/323 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly   478 RNAAPIHHFCQTPMLDIQSHLRSEEDFQNYSITINQVGGSDFK----SKAPKASTGSLLDSGDSS 538
            |.|....|   :|:..:...|.|.|...         |.|.:.    ||.......::..|.:.:
  Rat    64 REAEAYRH---SPVFQVYPLLNSMEGIP---------GSSPYASWAYSKTALYPASTVCPSHEDA 116

  Fly   539 DSHKLEMDITSSIN--------DRKTPDSLSSDHA--TDAATTQLWQALARSAAKSKEDNPASQI 593
            .|..||.....:.|        :|.:||.|:...|  |....|        |:|....|.|:
  Rat   117 PSQTLEDPDGKNNNTFLETLKTERLSPDLLTLGTALPTSLPVT--------SSAYGGADFPS--- 170

  Fly   594 FRNMMSQPFAFPVPSTVSFTKVPEEPIALLKDLSEAQSSKS-------KPCRRKQSFPTKTDCID 651
                   ||..|..|.:|               |.|.||..       .||..:       :|
  Rat   171 -------PFFSPTGSPLS---------------SAAYSSPKFHGSLPLAPCEAR-------EC-- 204

  Fly   652 VVNENVTDTYTTSEATPDDKKDKRNINLFNA---------------------IPGAQKDMSCSNC 695
             ||...|       |||..::|:....|.||                     |...:....|:||
  Rat   205 -VNCGAT-------ATPLWRRDRTGHYLCNACGLYHKMNGQNRPLIRPKKRMIVSKRAGTQCTNC 261

  Fly   696 GTLTTTIWRRSVRGEMVCNACGLYFKLHGVNRPHSMRRDTIHTRRRRPKELERSKKKHKQMSS 758
            .|.|||:|||:..|:.||||||||:|||.||||.:||:|.|.||.|:..    .|.|.|:.||
  Rat   262 QTTTTTLWRRNASGDPVCNACGLYYKLHQVNRPLTMRKDGIQTRNRKAS----GKGKKKRGSS 320

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GATAd	NP_001260326.1	zf-AD	<228..284	CDD:214871
		ZnF_GATA	688..736	CDD:214648	29/47 (62%)
		ZnF_GATA	691..742	CDD:238123	32/50 (64%)
Gata1	NP_036896.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	109..128		4/18 (22%)
		Interaction with MED1 and CCAR1. /evidence=ECO:0000250\|UniProtKB:P15976	200..330		50/142 (35%)
		ZnF_GATA	202..247	CDD:214648	11/61 (18%)
		ZnF_GATA	203..249	CDD:238123	11/55 (20%)
		Required for interaction with ZFPM1. /evidence=ECO:0000250	203..222		8/28 (29%)
		Interaction with CALCOCO1. /evidence=ECO:0000250\|UniProtKB:P15976	249..315		35/69 (51%)
		ZnF_GATA	<268..308	CDD:238123	25/39 (64%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..325		12/28 (43%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..413
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334659
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.830