DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GATAd and elt-6

DIOPT Version :9

Sequence 1:	NP_001260326.1	Gene:	GATAd / 34395	FlyBaseID:	FBgn0032223	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_500144.2	Gene:	elt-6 / 176993	WormBaseID:	WBGene00001253	Length:	367	Species:	Caenorhabditis elegans

Alignment Length:	451	Identity:	101/451 - (22%)
Similarity:	167/451 - (37%)	Gaps:	116/451 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly   378 MSGSSHSQFDSKLQKDSDIEKYENLQQQLETAAVLMDISKKIVISPPCSNPQSPCFSAAVDTSIK 442
            |:.|.....|..:.::.:.|..:.:::...|||.             |:.    |  |.:...|:
Worm     1 MTSSKEEMPDEMVSREVEEEMEDRVEETATTAAA-------------CTG----C--AQLHKDIR 46

  Fly   443 SSVIKSKRPSNQNEIQDGVEIDLSVKKQKNDYSNQRNAAPIHHFCQTPMLDIQSHLRSEEDF--- 504
            ..|  ||..|..:|:...:|..:|.|::                   .:|:..|...|||.:
Worm    47 QDV--SKMMSKIDEVCGRLEALISEKEK-------------------VLLEQMSESGSEEKYPPS 90

  Fly   505 ----QNYSITINQVGGSDFKSKAPKASTGSLLDSGDSSDSHKLEMDITSSINDRKTPDSLSSDHA 565
                :....::.:..|...|.|..|.|....|::|.|....:   .||.:|:   ||.|.||..
Worm    91 PTESRASPSSVGKSNGGCRKRKPTKESVNRHLENGGSDSPFE---KITRNIS---TPVSASSPF- 148

  Fly   566 TDAATTQLWQALARSAAKSKEDNPASQIFRNMMSQPFAFPVPSTVSFTKVPEEP-IALLKDLSEA 629
                                   |..|.|...:..|.|.|.........|.::. .|.....::.
Worm   149 -----------------------PDFQNFNGFVFDPMANPQNMMNLLNLVQQQQHQAAAHHHAQQ 190

  Fly   630 QSSKSKPCR---RKQSFPTKTDCIDVVNENVTDTYTTSEATPDD-------KKDKRNINLFN-AI 683
            |:.:.||.:   .||..|::       |.|.:.:.:..:...|.       |.....::... |.
Worm   191 QAREQKPVKAEESKQQEPSE-------NRNQSPSASVEQTLLDQLSMQFNGKSPSPTVHASTAAA 248

  Fly   684 PGAQKD--------MSCSNCGTLTTTIWRRSVRGEMVCNACGLYFKLHGVNRPHSMRRDTIHTR- 739
            .|:.:|        ..||||.|:.||.|||.:.|::||||||||::||..:||..||:|.|..|
Worm   249 AGSSEDDTSANSSISKCSNCSTIKTTAWRRDLEGKLVCNACGLYYRLHRTHRPVHMRKDFIQQRF 313

  Fly   740 RRRPKELERSKKKH----KQMSSCSSIETTKQDFLTARESLAISGLVLNKFKKEIDDTETP 796
            |||.:|.|......    .|:....|:.....:.||..|.       :|:..:..:..::|
Worm   314 RRRMREDENPATSQAAVFSQLLGLPSMANGGANALTFLEQ-------INQLNQSQEQRKSP 367

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GATAd	NP_001260326.1	zf-AD	<228..284	CDD:214871
		ZnF_GATA	688..736	CDD:214648	27/55 (49%)
		ZnF_GATA	691..742	CDD:238123	29/51 (57%)
elt-6	NP_500144.2	GAT1	<254..>367	CDD:227928	40/119 (34%)
elt-6	NP_500144.2	ZnF_GATA	264..315	CDD:238123	28/50 (56%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	59	1.000	Domainoid score	I7067
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	1	1.000	-	-		otm14342
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10071
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.910