DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment GATAd and Gata1

DIOPT Version :9

Sequence 1:	NP_001260326.1	Gene:	GATAd / 34395	FlyBaseID:	FBgn0032223	Length:	842	Species:	Drosophila melanogaster
Sequence 2:	NP_032115.1	Gene:	Gata1 / 14460	MGIID:	95661	Length:	413	Species:	Mus musculus

Alignment Length:	353	Identity:	93/353 - (26%)
Similarity:	128/353 - (36%)	Gaps:	108/353 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   478 RNAAPIHHFCQTPMLDIQSHLRSEEDFQNYSITINQVGGSDFKS----KAPKASTGSLLDSGDSS 538
            |.|....|   :|:..:...|.|.|...         |||.:.|    |.......::..|.:.:
Mouse    64 REAEAYRH---SPVFQVYPLLNSMEGIP---------GGSPYASWAYGKTALYPASTVCPSHEDA 116

  Fly   539 DSHKLEMDITSSIN--------DRKTPDSLSSDHATDAATTQLWQALARSAAKSKEDNPASQIFR 595
            .|..||.....|.|        :|.:||.|:...|..|:..      ...:|....|.|:
Mouse   117 PSQALEDQEGKSNNTFLDTLKTERLSPDLLTLGTALPASLP------VTGSAYGGADFPS----- 170

  Fly   596 NMMSQPFAFPVPSTVSFTKVPEEPIALLKDLSEAQSSKS-------KPCRRKQSFPTKTDCIDVV 653
                 ||..|..|.:|               |.|.||..       .||..:       :|   |
Mouse   171 -----PFFSPTGSPLS---------------SAAYSSPKFHGSLPLAPCEAR-------EC---V 205

  Fly   654 NENVTDTYTTSEATPDDKKDKRNINLFNA---------------------IPGAQKDMSCSNCGT 697
            |...|       |||..::|:....|.||                     |...:....|:||.|
Mouse   206 NCGAT-------ATPLWRRDRTGHYLCNACGLYHKMNGQNRPLIRPKKRMIVSKRAGTQCTNCQT 263

  Fly   698 LTTTIWRRSVRGEMVCNACGLYFKLHGVNRPHSMRRDTIHTRRRRPKELERSKKKHKQMSSCSSI 762
            .|||:|||:..|:.||||||||||||.||||.:||:|.|.||.|:... :..||:...::...:.
Mouse   264 TTTTLWRRNASGDPVCNACGLYFKLHQVNRPLTMRKDGIQTRNRKASG-KGKKKRGSNLAGAGAA 327

  Fly   763 ETTKQDFLTARESLA-------ISGLVL 783
            |.....|:....|.:       .|||.|
Mouse   328 EGPAGGFMVVAGSSSSGNCGEVASGLAL 355

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
GATAd	NP_001260326.1	zf-AD	<228..284	CDD:214871
		ZnF_GATA	688..736	CDD:214648	30/47 (64%)
		ZnF_GATA	691..742	CDD:238123	33/50 (66%)
Gata1	NP_032115.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..49
		Interaction with MED1 and CCAR1. /evidence=ECO:0000269\|PubMed:24245781	200..330		49/147 (33%)
		ZnF_GATA	203..249	CDD:238123	11/55 (20%)
		Required for interaction with ZFPM1. /evidence=ECO:0000250	203..222		8/28 (29%)
		Interaction with CALCOCO1. /evidence=ECO:0000269\|PubMed:24245781	249..315		35/66 (53%)
		ZnF_GATA	<268..308	CDD:238123	26/39 (67%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..325		9/28 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	391..413
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167830950
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5641
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000130
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.740