DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Schip1 and Schip1

DIOPT Version :9

Sequence 1:	NP_001334735.1	Gene:	Schip1 / 34393	FlyBaseID:	FBgn0032221	Length:	621	Species:	Drosophila melanogaster
Sequence 2:	NP_001094136.1	Gene:	Schip1 / 295105	RGDID:	1309962	Length:	560	Species:	Rattus norvegicus

Alignment Length:	623	Identity:	139/623 - (22%)
Similarity:	237/623 - (38%)	Gaps:	183/623 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 ESVNRSENIPDIVNENYSATSENSKRALQKPDLIYNLSQNYTTNP----EFPSWSCTINSKYEGQ 152
            |.:.|.:|..:.|        ::.|..|:...|..::..|....|    ...|....|...:...
  Rat     4 EELKRLQNPLEQV--------DDGKYLLENHQLATDMENNIENYPLSLQPLESKVKIIQRAWREY 60

  Fly   153 LQGQSPIDIVGDFGGEVEREFELLLTGYKNKKEADELKGS-NLDKICDAE--------LSNGTEA 208
            ||.|.|::........|               .:|:|..| :::...|:.        :..|::|
  Rat    61 LQRQDPLEKRSPSPPSV---------------SSDKLSSSVSMNTFSDSSTPDYREDGMDLGSDA 110

  Fly   209 LKQTSSTRLSGNSTRKNKKKNTPYGHQIVKTKHPKPSHDERQLPPDTFDYK----TYSQRKYIIC 269
            ...:||:|.|..|   |..|.||.. :...:..|..|.|   |.....||:    .| |:|.|..
  Rat   111 GSSSSSSRASSQS---NSTKVTPCS-ECKSSSSPGGSLD---LVSALEDYEEPFPVY-QKKVIDE 167

  Fly   270 DADQYSSVPEKNKNDSPNLNQ---AEIPNMSSLEIGGSGS----------------------QQN 309
            .|.:.....|:.::|....:.   |..|...|..||||||                      .|:
  Rat   168 WAPEEDGEEEEEEDDRGYRDDRCPAREPGDVSARIGGSGSGNRSAATTMPSPMPNGNLHPHDPQD 232

  Fly   310 LDEDNNKVASRKYSNQSRWSQYLEDPIKYSKDP----------CSTMVLEQFD-AYKI-----AN 358
            |..:.|.|.:.: .|.||..:   .||:.::.|          ...:.|:..| ..::     |.
  Rat   233 LRHNGNLVIAGR-PNASRVPR---RPIQKTQPPGNRRGGRNRASGGLCLQPPDGGMRVPEEPPAP 293

  Fly   359 DMDVETLQNHYKKVKQIEKK--------------RRFNRDEIRKRLAIGD--------------- 394
            .||.|.|:.|...::..|::              ::..|:.||::||:|.
  Rat   294 PMDWEALEKHLAGLQFREQEVRNQGQARTNSTSAQKNERESIRQKLALGSFFDDGPGIYTSCSKS 358

  Fly   395 -KDSLNNDIKKEEFL-------TGSDNESYSSDSETCPKLSSGV--LRKQSEFCETKRNKEFEND 449
             |.||::.::....|       :|||.:|.:.||:|...|.:.:  :.|||.....:...|.|::
  Rat   359 GKPSLSSRLQSGMNLQICFVNDSGSDKDSDADDSKTETSLDTPLSPMSKQSSSYSDRDTTEEESE 423

  Fly   450 KIFQKNQINQDKSMNHMNGNPIGTTDYPSDENLFFFANQSKLQIEVRIALAQSKEIAQMKVKARK 514
            .:                            :::.|...|.|||.|.::|||.:|.:|:|:|:..|
  Rat   424 SL----------------------------DDMDFLTRQKKLQAEAKMALAMAKPMAKMQVEVEK 460

  Fly   515 HG--VTPIVDVIRSMLCDVGIKMNSNHRWISRQLLTGIQVPT---------LQLLVNNLQEYIEN 568
            ..  .:|:.|::..|          .|  ||..|:.....||         ||::||:|...||:
  Rat   461 QNRKKSPVADLLPHM----------PH--ISECLMKRSLKPTDLRDMTIGQLQVIVNDLHSQIES 513

  Fly   569 LNVTLLESLKERDDLNSDQDDILHDLEKINNFFVFQQQ 606
            ||..|::.|..||:|:::||.:|.|:|.:......||:
  Rat   514 LNEELVQLLLIRDELHTEQDAMLVDIEDLTRHAESQQK 551

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Schip1	NP_001334735.1	None
Schip1	NP_001094136.1	IQCJ-SCHIP1	4..>97	CDD:291814	16/96 (17%)
Schip1	NP_001094136.1	SCHIP-1	328..554	CDD:287158	53/204 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353790
Domainoid	1	1.000	66	1.000	Domainoid score	I9731
eggNOG	1	0.900	-	-		E1_KOG4847
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003916
OrthoInspector	1	1.000	-	-		oto96965
orthoMCL	1	0.900	-	-		OOG6_108210
Panther	1	1.100	-	-	LDO	PTHR13103
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	9	8.790