DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Schip1 and IQCJ-SCHIP1

DIOPT Version :9

Sequence 1:	NP_001334735.1	Gene:	Schip1 / 34393	FlyBaseID:	FBgn0032221	Length:	621	Species:	Drosophila melanogaster
Sequence 2:	NP_001184042.1	Gene:	IQCJ-SCHIP1 / 100505385	HGNCID:	38842	Length:	563	Species:	Homo sapiens

Alignment Length:	632	Identity:	134/632 - (21%)
Similarity:	238/632 - (37%)	Gaps:	198/632 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    92 ESVNRSENIPDIVNE-NYSATSENSKRALQKPDLIYNLSQNYTTNPE-FPSWSCTINSKYEGQLQ 154
            |.:.|.:|..:.||: .||  .||.:.|:...:.|    :.|..|.: ..|....|...:...||
Human     4 EELKRLQNPLEQVNDGKYS--FENHQLAMDAENNI----EKYPLNLQPLESKVKIIQRAWREYLQ 62

  Fly   155 GQSPIDIVGDFGGEVEREFELLLTGYKNKK----EADELKGS-NLDKICDAE--------LSNGT 206
            .|.|:                   |.::..    .:::|..| :::...|:.        :..|:
Human    63 RQEPL-------------------GKRSPSPPSVSSEKLSSSVSMNTFSDSSTPDYREDGMDLGS 108

  Fly   207 EALKQTSSTRLSGNSTRKNKKKNTPYGHQIVKTKHPKPSHDERQLPPDTFDYK----TYSQRKYI 267
            :|...:||:|.|..|   |..|.||.. :...:..|..|.|   |.....||:    .| |:|.|
Human   109 DAGSSSSSSRASSQS---NSTKVTPCS-ECKSSSSPGGSLD---LVSALEDYEEPFPVY-QKKVI 165

  Fly   268 ICDADQYS------SVPEKNKNDSPNLNQAEIPNMSSLEI------GGSGSQ------------- 307
                |:::      ...|:::.|.........|.....::      ||.|.:
Human   166 ----DEWAPEEDGEEEEEEDERDQRGYRDDRSPAREPGDVSARTRSGGGGGRSATTAMPPPVPNG 226

  Fly   308 -------QNLDEDNNKVASRKYSNQSRWSQYLEDP-----IKYSKDPCS-----------TMVLE 349
                   |:|..:.|.|.:.:.|......:.::.|     .:..:.|.:           |.|.|
Human   227 NLHQHDPQDLRHNGNVVVAGRPSCSRGPRRAIQKPQPAGGRRSGRGPAAGGLCLQPPDGGTCVPE 291

  Fly   350 QFDAYKIANDMDVETLQNHYKKVKQIEKK--------------RRFNRDEIRKRLAIGD------ 394
            :    .....||.|.|:.|...::..|::              ::..|:.||::||:|.
Human   292 E----PPVPPMDWEALEKHLAGLQFREQEVRNQGQARTNSTSAQKNERESIRQKLALGSFFDDGP 352

  Fly   395 ----------KDSLNNDIKKEEFL-------TGSDNESYSSDSETCPKLSSGV--LRKQSEFCET 440
                      |.||::.::....|       :|||.:|.:.||:|...|.:.:  :.|||.....
Human   353 GIYTSCSKSGKPSLSSRLQSGMNLQICFVNDSGSDKDSDADDSKTETSLDTPLSPMSKQSSSYSD 417

  Fly   441 KRNKEFENDKIFQKNQINQDKSMNHMNGNPIGTTDYPSDENLFFFANQSKLQIEVRIALAQSKEI 505
            :...|.|::.:                            :::.|...|.|||.|.::|||.:|.:
Human   418 RDTTEEESESL----------------------------DDMDFLTRQKKLQAEAKMALAMAKPM 454

  Fly   506 AQMKVKARKHG--VTPIVDVIRSMLCDVGIKMNSNHRWISRQLLTGIQVPT---------LQLLV 559
            |:|:|:..|..  .:|:.|::..|          .|  ||..|:.....||         ||::|
Human   455 AKMQVEVEKQNRKKSPVADLLPHM----------PH--ISECLMKRSLKPTDLRDMTIGQLQVIV 507

  Fly   560 NNLQEYIENLNVTLLESLKERDDLNSDQDDILHDLEKINNFFVFQQQ 606
            |:|...||:||..|::.|..||:|:::||.:|.|:|.:......||:
Human   508 NDLHSQIESLNEELVQLLLIRDELHTEQDAMLVDIEDLTRHAESQQK 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Schip1	NP_001334735.1	None
IQCJ-SCHIP1	NP_001184042.1	IQCJ-SCHIP1	4..>99	CDD:317561	23/119 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..150		21/112 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	164..295		18/138 (13%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	312..336		1/23 (4%)
		SCHIP-1	331..557	CDD:287158	67/264 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	384..430		13/73 (18%)
		Required for interaction with ankyrins. /evidence=ECO:0000250\|UniProtKB:A0A088MLT8	419..563		46/176 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165159720
Domainoid	1	1.000	66	1.000	Domainoid score	I9935
eggNOG	1	0.900	-	-		E1_KOG4847
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003916
OrthoInspector	1	1.000	-	-		otm41249
orthoMCL	1	0.900	-	-		OOG6_108210
Panther	1	1.100	-	-	LDO	PTHR13103
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	8	7.790