DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RnrL and RRM1

DIOPT Version :9

Sequence 1:	NP_477027.1	Gene:	RnrL / 34392	FlyBaseID:	FBgn0011703	Length:	812	Species:	Drosophila melanogaster
Sequence 2:	NP_001024.1	Gene:	RRM1 / 6240	HGNCID:	10451	Length:	792	Species:	Homo sapiens

Alignment Length:	801	Identity:	597/801 - (74%)
Similarity:	687/801 - (85%)	Gaps:	9/801 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LYVIKRDGRQEEVHFDKITSRIQKLCYNLNMDFVDPVTITLQVINGLYCGVTTQELDNLAAEIAA 76
            ::|||||||||.|.|||||||||||||.||||||||..||::||.|||.||||.|||.||||.||
Human     1 MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLAAETAA 65

  Fly    77 GLTCNHPDYAILAARIAVSNLHKETKKAFSDVFEDLYNHVNKETNQKVPLVSEFHYNVVKKNATR 141
            .||..||||||||||||||||||||||.||||.|||||::|....:..|:|::...::|..|..|
Human    66 TLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGKHSPMVAKSTLDIVLANKDR 130

  Fly   142 LNSSIIYDRDFGYNYFGFKTLERSYLLKRNGKIAERPQHMLMRVAIGIHGEDIDAAVETYNLLSE 206
            |||:|||||||.||||||||||||||||.|||:|||||||||||::|||.||||||:||||||||
Human   131 LNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSE 195

  Fly   207 RYFTHASPTLFAAATNRPQLSSCFLLTMTADSIEGIFKSVEQCAMISKSAGGIGLNVHCIRAKGT 271
            |:|||||||||.|.||||||||||||:|..||||||:.:::|||:|||||||||:.|.||||.|:
Human   196 RWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGS 260

  Fly   272 SICGTNGTSNGLVPMLRVFNNVARYVDQGGGKRPGAFAIYLEPWHSDVFEFLELKKNTGKEENRA 336
            .|.||||.||||||||||:||.||||||||.||||||||||||||.|:||||:|||||||||.||
Human   261 YIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRA 325

  Fly   337 RDLFYALWIPDLFMKRVEANGDWSLMCPHKCPGLHDVWGDEFEKLYEKYEQEGRANRTVKAQSLW 401
            ||||:|||||||||||||.|.|||||||::||||.:|||:||||||..||::||..:.||||.||
Human   326 RDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYASYEKQGRVRKVVKAQQLW 390

  Fly   402 FAIIEAQVETGNPYMLFKDACNRKSNQQNVGTIKCSNLCTEIVEYSAPDEIAVCNLASIALNMFV 466
            :||||:|.|||.||||:||:|||||||||:|||||||||||||||::.||:|||||||:||||:|
Human   391 YAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYV 455

  Fly   467 TPEKTYDFKKLKEVTKIVTKNLNKIIDINYYPLPEARKSNLRHRPVGIGIQGFADALILMRFPYE 531
            |.|.|||||||.||||:|.:||||||||||||:|||..||.||||:|||:||.|||.||||:|:|
Human   456 TSEHTYDFKKLAEVTKVVVRNLNKIIDINYYPVPEACLSNKRHRPIGIGVQGLADAFILMRYPFE 520

  Fly   532 SEEAGLLNQQIFETIYYGALEASCELAQTEGPYETYEGSPVSKGILQYDMWDKVPTNLWDWQKLK 596
            |.||.|||:|||||||||||||||:||:.:|||||||||||||||||||||:..||:||||:.||
Human   521 SAEAQLLNKQIFETIYYGALEASCDLAKEQGPYETYEGSPVSKGILQYDMWNVTPTDLWDWKVLK 585

  Fly   597 ESIRMHGVRNSLLVAPMPTASTAQIMGNNESFEPYTTNIYTRRVLSGEFQVVNHHLLRDLTELDL 661
            |.|..:|:|||||:|||||||||||:|||||.||||:|||||||||||||:||.|||:||||..|
Human   586 EKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGL 650

  Fly   662 WDDDMKNQIISSRGSIQNIETIPPKVRDLYKTVWEISVKSTIKMAADRGAFIDQSQSFNIHVAEP 726
            |.::||||||:..||||:|..||..::.|||||||||.|:.:||||:||||||||||.|||:|||
Human   651 WHEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEP 715

  Fly   727 NYGKLTSIHFYSWKAGLKTGMYYLRTKPAANAIQFTVNKKQGAVSMNGQNGTAEGSPQKYEEDRE 791
            |||||||:|||.||.|||||||||||:||||.||||:||::    :..:...:     |.||::|
Human   716 NYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEK----LKDKEKVS-----KEEEEKE 771

  Fly   792 RKMADMVCSLENKDACMSCGS 812
            |..|.|||||||:|.|:.|||
Human   772 RNTAAMVCSLENRDECLMCGS 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RnrL	NP_477027.1	PLN02437	12..812	CDD:178056	595/799 (74%)
RRM1	NP_001024.1	PLN02437	1..792	CDD:178056	595/799 (74%)
RRM1	NP_001024.1	GDP binding. /evidence=ECO:0007744\|PDB:3HND	604..607		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160112
Domainoid	1	1.000	855	1.000	Domainoid score	I58
eggNOG	1	0.900	-	-		E1_COG0209
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H806
Inparanoid	1	1.050	1241	1.000	Inparanoid score	I181
Isobase	1	0.950	-	0	Normalized mean entropy	S121
OMA	1	1.010	-	-		QHG62381
OrthoDB	1	1.010	-	-		D156716at2759
OrthoFinder	1	1.000	-	-		FOG0003792
OrthoInspector	1	1.000	-	-		oto90931
orthoMCL	1	0.900	-	-		OOG6_100448
Panther	1	1.100	-	-	LDO	PTHR11573
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1104
SonicParanoid	1	1.000	-	-		X2647
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	17	16.750