Protein Alignment RnrL and RRM1

DIOPT Version :10

• Sequence 1: NP_477027.1
• Gene: RnrL / 34392
• FlyBaseID: FBgn0011703
• Length: 812
• Species: Drosophila melanogaster
• Sequence 2: NP_001024.1
• Gene: RRM1 / 6240
• HGNCID: 10451
• Length: 792
• Species: Homo sapiens
• Alignment Length: 586
• Identity: 116/586 - (19%)
• Similarity: 182/586 - (31%)
• Gaps: 231/586 - (39%)

  Fly    17 PSHNLSVRYRFNFRIGCFTCGGKAAATTPDCLY----------YYC---TTC---------EVTF 59
            |:.:|.:||...      .|.||....|| .|:          |:|   |.|         ||:.
Human    93 PNMSLIIRYTLG------RCDGKTVIPTP-YLFRKKKESPIPNYFCNEETMCSYLLTGPHWEVSL 150

  Fly    60 ----HNGCHQRPR--RITH-PYHL------QHPLTLFYRNPETRV---------------ISNII 96
                |......||  ::|: |:|.      |:|........:|.:               |..:|
Human   151 GFWKHMNSFLSPRILQLTYGPFHSIFSDDEQYPYLYQMAPKDTSLALAMVSFILYFSWNWIGLVI 215

  Fly    97 PDACPG------------------------KIEDTSGP----------------------EKYEF 115
            ||...|                        .::|.|.|                      |.|.|
Human   216 PDDDQGNQFLLELKKQSENKEICFAFVKMISVDDVSFPQNTEMYYNQIVMSSTNVIIIYGETYNF 280

  Fly   116 VDIVPYKSDIIFNKCTWCAKDFKGDWFYRCLICSFCLDLSCAATLPLLTITNPK---SH---HHS 174
            :       |:||.  .|.....:..|.                |...|.....|   ||   :.|
Human   281 I-------DLIFR--MWEPPILQRIWI----------------TTKQLNFPTRKTDISHGTFYGS 320

  Fly   175 LVFLPRPLLVPCDACGLVDGLEPSYACFQCNYM---VHQNCIDLPRVIKITRHPHRLSHTPYC-- 234
            |.|||..        |::.|.:        |::   .|....||..|::..::.:.......|
Human   321 LTFLPHH--------GVISGFK--------NFVQTWFHLRNTDLYLVMQDWKYFNYEDSASTCKI 369

  Fly   235 ----SSLTSSCQICYKEVDIKYGQYSCHLQDCFY-VVHSKCATHENVWDGKELEWEIESDETEDI 294
                ||..|...:..::.|:.:.:.|.::.:..: :.|   |.|         |..::..:.:.|
Human   370 LKNNSSNASFDWLMEQKFDMTFSENSHNIYNAVHAIAH---ALH---------EMNLQQADNQAI 422

  Fly   295 SPFRNLGDGFIKHFCHK-----HRLKLKNHDGARDTEKQCRACI---YPIVSHQFYHCKKCNYSL 351
                :.|.|...| |.|     .|:...|..|.:...|| |..:   |.||..       .|.|.
Human   423 ----DNGKGASSH-CLKVNSFLRRIYFTNPPGDKVFMKQ-RVIMQDEYDIVHF-------VNLSQ 474

  Fly   352 HEVCAGLSRK-------LDHALHNHTLI----LSPSPGKFCCSACSRE-STGF-----------S 393
            |   .|:..|       |.|..|:|..:    |:....|...|.||.: |.||           .
Human   475 H---LGIKMKLGKFSPYLPHGRHSHLYVDRIELATGRRKMPSSVCSADCSPGFRRLWKEGMAACC 536

  Fly   394 YICSNKGCQDFVLDVRCISVLEYFIHRSHEHPIFISTSYNSKDEILCKVCKKRCLGAHLQCTLCE 458
            ::||  .|.:..:......||..|: :.|:.|| :..:..|...:|        |.:.:.|.||.
Human   537 FVCS--PCPENEISNETTVVLCVFV-KHHDTPI-VKANNRSLSYLL--------LMSLMSCFLCS 589

  Fly   459 F 459
            |
Human   590 F 590

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RnrL	NP_477027.1	PLN02437	12..812	CDD:178056	116/586 (20%)
RRM1	NP_001024.1	PLN02437	1..792	CDD:178056	116/586 (20%)