DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RnrL and rrm1

DIOPT Version :9

Sequence 1:	NP_477027.1	Gene:	RnrL / 34392	FlyBaseID:	FBgn0011703	Length:	812	Species:	Drosophila melanogaster
Sequence 2:	NP_571530.2	Gene:	rrm1 / 30740	ZFINID:	ZDB-GENE-990415-247	Length:	794	Species:	Danio rerio

Alignment Length:	801	Identity:	598/801 - (74%)
Similarity:	680/801 - (84%)	Gaps:	7/801 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LYVIKRDGRQEEVHFDKITSRIQKLCYNLNMDFVDPVTITLQVINGLYCGVTTQELDNLAAEIAA 76
            ::|||||||||.|.|||||||||||||.||.|||||..||::||.|||.||||.|||.|||||||
Zfish     1 MHVIKRDGRQERVMFDKITSRIQKLCYGLNSDFVDPTQITMKVIQGLYSGVTTVELDTLAAEIAA 65

  Fly    77 GLTCNHPDYAILAARIAVSNLHKETKKAFSDVFEDLYNHVNKETNQKVPLVSEFHYNVVKKNATR 141
            .||..||||||||||||||||||||||.||:|.|||||:||...::..|::|:...::|..|..|
Zfish    66 TLTTKHPDYAILAARIAVSNLHKETKKVFSEVMEDLYNYVNPLNSRHSPMISKETLDIVLANKDR 130

  Fly   142 LNSSIIYDRDFGYNYFGFKTLERSYLLKRNGKIAERPQHMLMRVAIGIHGEDIDAAVETYNLLSE 206
            |||:|||||||.||:|||||||||||||.|||:|||||||||||::|||.|||.||:||||||||
Zfish   131 LNSAIIYDRDFSYNFFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHKEDIAAAIETYNLLSE 195

  Fly   207 RYFTHASPTLFAAATNRPQLSSCFLLTMTADSIEGIFKSVEQCAMISKSAGGIGLNVHCIRAKGT 271
            ::|||||||||.|.||||||||||||.|..||||||:.:::|||:|||||||||:.|.||||.|:
Zfish   196 KWFTHASPTLFNAGTNRPQLSSCFLLAMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGS 260

  Fly   272 SICGTNGTSNGLVPMLRVFNNVARYVDQGGGKRPGAFAIYLEPWHSDVFEFLELKKNTGKEENRA 336
            .|.||||.||||||||||:||.||||||||.|||||||:||||||.|:|:||||||||||||.||
Zfish   261 YIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAMYLEPWHFDIFDFLELKKNTGKEEQRA 325

  Fly   337 RDLFYALWIPDLFMKRVEANGDWSLMCPHKCPGLHDVWGDEFEKLYEKYEQEGRANRTVKAQSLW 401
            ||||||||||||||||||.|||||||||:.||||.:.||:||||||.||||||||.|.||||.||
Zfish   326 RDLFYALWIPDLFMKRVETNGDWSLMCPNDCPGLDECWGEEFEKLYAKYEQEGRAKRVVKAQQLW 390

  Fly   402 FAIIEAQVETGNPYMLFKDACNRKSNQQNVGTIKCSNLCTEIVEYSAPDEIAVCNLASIALNMFV 466
            :||||:|.|||.||||:||||||||||||:|||||||||||||||::.||:||||||||||||:|
Zfish   391 YAIIESQTETGTPYMLYKDACNRKSNQQNLGTIKCSNLCTEIVEYTSADEVAVCNLASIALNMYV 455

  Fly   467 TPEKTYDFKKLKEVTKIVTKNLNKIIDINYYPLPEARKSNLRHRPVGIGIQGFADALILMRFPYE 531
            |.|:|:||:||..|||::.|||||||||||||:.||..||.||||:|||:||.|||.||||||:|
Zfish   456 TSERTFDFQKLASVTKVIVKNLNKIIDINYYPVKEAENSNKRHRPIGIGVQGLADAFILMRFPFE 520

  Fly   532 SEEAGLLNQQIFETIYYGALEASCELAQTEGPYETYEGSPVSKGILQYDMWDKVPTNLWDWQKLK 596
            |.||.|||.||||||||.|||:|||||...|||:||.|.||||||||||||:|.||:||||..||
Zfish   521 SAEAQLLNTQIFETIYYAALESSCELAAEYGPYQTYAGCPVSKGILQYDMWEKTPTDLWDWAALK 585

  Fly   597 ESIRMHGVRNSLLVAPMPTASTAQIMGNNESFEPYTTNIYTRRVLSGEFQVVNHHLLRDLTELDL 661
            |.|..||||||||:|||||||||||:|||||.||||:|||||||||||||:||.|||:||||..|
Zfish   586 EKIAKHGVRNSLLLAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGL 650

  Fly   662 WDDDMKNQIISSRGSIQNIETIPPKVRDLYKTVWEISVKSTIKMAADRGAFIDQSQSFNIHVAEP 726
            |:::||||||:..||||.|..||..:::|||||||||.|:.:||||||||:||||||.|||:|||
Zfish   651 WNEEMKNQIIAQNGSIQTIPAIPDDLKELYKTVWEISQKTILKMAADRGAYIDQSQSLNIHIAEP 715

  Fly   727 NYGKLTSIHFYSWKAGLKTGMYYLRTKPAANAIQFTVNKKQGAVSMNGQNGTAEGSPQKYEEDRE 791
            |||||||:|||.||.||||||||||||||||.||||:||::       ...|.:.:..:.||.:|
Zfish   716 NYGKLTSMHFYGWKQGLKTGMYYLRTKPAANPIQFTLNKEK-------LKETQKTTSSEDEETKE 773

  Fly   792 RKMADMVCSLENKDACMSCGS 812
            |..|.|||||||:|.|:.|||
Zfish   774 RNKAAMVCSLENRDECLMCGS 794

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RnrL	NP_477027.1	PLN02437	12..812	CDD:178056	596/799 (75%)
rrm1	NP_571530.2	PLN02437	1..794	CDD:178056	596/799 (75%)
		ATP-cone	1..89	CDD:281475	70/87 (80%)
		RNR_I	167..741	CDD:153088	446/573 (78%)
		GDP binding. /evidence=ECO:0000250\|UniProtKB:P23921	604..607		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596435
Domainoid	1	1.000	848	1.000	Domainoid score	I59
eggNOG	1	0.900	-	-		E1_COG0209
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H806
Inparanoid	1	1.050	1212	1.000	Inparanoid score	I184
OMA	1	1.010	-	-		QHG62381
OrthoDB	1	1.010	-	-		D156716at2759
OrthoFinder	1	1.000	-	-		FOG0003792
OrthoInspector	1	1.000	-	-		oto39893
orthoMCL	1	0.900	-	-		OOG6_100448
Panther	1	1.100	-	-	LDO	PTHR11573
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1104
SonicParanoid	1	1.000	-	-		X2647
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	16	15.800