DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RnrL and Rrm1

DIOPT Version :9

Sequence 1:	NP_477027.1	Gene:	RnrL / 34392	FlyBaseID:	FBgn0011703	Length:	812	Species:	Drosophila melanogaster
Sequence 2:	NP_033129.2	Gene:	Rrm1 / 20133	MGIID:	98180	Length:	792	Species:	Mus musculus

Alignment Length:	806	Identity:	598/806 - (74%)
Similarity:	687/806 - (85%)	Gaps:	19/806 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 LYVIKRDGRQEEVHFDKITSRIQKLCYNLNMDFVDPVTITLQVINGLYCGVTTQELDNLAAEIAA 76
            ::|||||||||.|.|||||||||||||.||||||||..||::||.|||.||||.|||.||||.||
Mouse     1 MHVIKRDGRQERVMFDKITSRIQKLCYGLNMDFVDPAQITMKVIQGLYSGVTTVELDTLAAETAA 65

  Fly    77 GLTCNHPDYAILAARIAVSNLHKETKKAFSDVFEDLYNHVNKETNQKVPLVSEFHYNVVKKNATR 141
            .||..||||||||||||||||||||||.||||.|||||::|....:..|:|:....::|..|..|
Mouse    66 TLTTKHPDYAILAARIAVSNLHKETKKVFSDVMEDLYNYINPHNGRHSPMVASSTLDIVMANKDR 130

  Fly   142 LNSSIIYDRDFGYNYFGFKTLERSYLLKRNGKIAERPQHMLMRVAIGIHGEDIDAAVETYNLLSE 206
            |||:|||||||.||||||||||||||||.|||:|||||||||||::|||.||||||:||||||||
Mouse   131 LNSAIIYDRDFSYNYFGFKTLERSYLLKINGKVAERPQHMLMRVSVGIHKEDIDAAIETYNLLSE 195

  Fly   207 RYFTHASPTLFAAATNRPQLSSCFLLTMTADSIEGIFKSVEQCAMISKSAGGIGLNVHCIRAKGT 271
            ::|||||||||.|.||||||||||||:|..||||||:.:::|||:|||||||||:.|.||||.|:
Mouse   196 KWFTHASPTLFNAGTNRPQLSSCFLLSMKDDSIEGIYDTLKQCALISKSAGGIGVAVSCIRATGS 260

  Fly   272 SICGTNGTSNGLVPMLRVFNNVARYVDQGGGKRPGAFAIYLEPWHSDVFEFLELKKNTGKEENRA 336
            .|.||||.||||||||||:||.||||||||.||||||||||||||.|:||||:|||||||||.||
Mouse   261 YIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHLDIFEFLDLKKNTGKEEQRA 325

  Fly   337 RDLFYALWIPDLFMKRVEANGDWSLMCPHKCPGLHDVWGDEFEKLYEKYEQEGRANRTVKAQSLW 401
            ||||:|||||||||||||.|.|||||||::||||.:|||:|||||||.||::||..:.||||.||
Mouse   326 RDLFFALWIPDLFMKRVETNQDWSLMCPNECPGLDEVWGEEFEKLYESYEKQGRVRKVVKAQQLW 390

  Fly   402 FAIIEAQVETGNPYMLFKDACNRKSNQQNVGTIKCSNLCTEIVEYSAPDEIAVCNLASIALNMFV 466
            :||||:|.|||.||||:||:|||||||||:|||||||||||||||::.||:|||||||:||||:|
Mouse   391 YAIIESQTETGTPYMLYKDSCNRKSNQQNLGTIKCSNLCTEIVEYTSKDEVAVCNLASLALNMYV 455

  Fly   467 TPEKTYDFKKLKEVTKIVTKNLNKIIDINYYPLPEARKSNLRHRPVGIGIQGFADALILMRFPYE 531
            |||.||||:||.||||::.:||||||||||||:|||..||.||||:|||:||.|||.||||:|:|
Mouse   456 TPEHTYDFEKLAEVTKVIVRNLNKIIDINYYPIPEAHLSNKRHRPIGIGVQGLADAFILMRYPFE 520

  Fly   532 SEEAGLLNQQIFETIYYGALEASCELAQTEGPYETYEGSPVSKGILQYDMWDKVPTNLWDWQKLK 596
            |.||.|||:||||||||||||||||||:..|||||||||||||||||||||:..||:||||:.||
Mouse   521 SPEAQLLNKQIFETIYYGALEASCELAKEYGPYETYEGSPVSKGILQYDMWNVAPTDLWDWKPLK 585

  Fly   597 ESIRMHGVRNSLLVAPMPTASTAQIMGNNESFEPYTTNIYTRRVLSGEFQVVNHHLLRDLTELDL 661
            |.|..:|:|||||:|||||||||||:|||||.||||:|||||||||||||:||.|||:||||..|
Mouse   586 EKIAKYGIRNSLLIAPMPTASTAQILGNNESIEPYTSNIYTRRVLSGEFQIVNPHLLKDLTERGL 650

  Fly   662 WDDDMKNQIISSRGSIQNIETIPPKVRDLYKTVWEISVKSTIKMAADRGAFIDQSQSFNIHVAEP 726
            |:::||||||:..||||:|..||..::.|||||||||.|:.:||||:||||||||||.|||:|||
Mouse   651 WNEEMKNQIIACNGSIQSIPEIPDDLKQLYKTVWEISQKTVLKMAAERGAFIDQSQSLNIHIAEP 715

  Fly   727 NYGKLTSIHFYSWKAGLKTGMYYLRTKPAANAIQFTVNK-----KQGAVSMNGQNGTAEGSPQKY 786
            |||||||:|||.||.|||||||||||:||||.||||:||     |:.|:              |.
Mouse   716 NYGKLTSMHFYGWKQGLKTGMYYLRTRPAANPIQFTLNKEKLKDKEKAL--------------KE 766

  Fly   787 EEDRERKMADMVCSLENKDACMSCGS 812
            ||::||..|.|||||||::.|:.|||
Mouse   767 EEEKERNTAAMVCSLENREECLMCGS 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RnrL	NP_477027.1	PLN02437	12..812	CDD:178056	596/804 (74%)
Rrm1	NP_033129.2	PLN02437	1..792	CDD:178056	596/804 (74%)
		ATP-cone	1..89	CDD:281475	70/87 (80%)
		RNR_I	167..741	CDD:153088	445/573 (78%)
		GDP binding. /evidence=ECO:0000250\|UniProtKB:P23921	604..607		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850483
Domainoid	1	1.000	863	1.000	Domainoid score	I55
eggNOG	1	0.900	-	-		E1_COG0209
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H806
Inparanoid	1	1.050	1237	1.000	Inparanoid score	I184
Isobase	1	0.950	-	0	Normalized mean entropy	S121
OMA	1	1.010	-	-		QHG62381
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003792
OrthoInspector	1	1.000	-	-		oto94515
orthoMCL	1	0.900	-	-		OOG6_100448
Panther	1	1.100	-	-	LDO	PTHR11573
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1104
SonicParanoid	1	1.000	-	-		X2647
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	16	15.740