DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4972 and zgc:109965

DIOPT Version :9

Sequence 1:	NP_609378.1	Gene:	CG4972 / 34388	FlyBaseID:	FBgn0032217	Length:	561	Species:	Drosophila melanogaster
Sequence 2:	XP_009293490.1	Gene:	zgc:109965 / 619266	ZFINID:	ZDB-GENE-050913-21	Length:	608	Species:	Danio rerio

Alignment Length:	562	Identity:	170/562 - (30%)
Similarity:	273/562 - (48%)	Gaps:	66/562 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LIVFSLLLTCSPVMPS----EFEVISMSKYDLNGQHYGSRVASISLEARSLYSWNTSRHCVLTRL 81
            |::.|:.|..:..:|:    ||....|..|:|:...:|.|.|.:..||||....:.:|.||:.:|
Zfish    68 LLLLSVHLLHASALPAASSYEFNAYRMQHYNLHQHKHGCRGAIVVAEARSAADTSLTRRCVIMKL 132

  Fly    82 TDLSIHDF-DKLRQGAGGLILMLPANILNLDPETKELITILEQSMLTHTAAVPIYFAPYNKDLEK 145
            .|.|...| :..:|.|..::::||.|:.::..||.:...:.|..:|.....:|:|..|.::.|..
Zfish   133 LDFSTERFLEAKKQNAAAVLILLPQNLSSVQEETVQGFMVAEAQILQEETILPVYVVPEDEQLLC 197

  Fly   146 IIDDITYTTTDSPGQNQTALAQLVVTVSANRYHINVGGGSIAANKNSKI-PIIHGELIPNQLALK 209
            :.:::..............:.:.::|.:|.:         |..:.||.| ||....:|..:..|.
Zfish   198 MYEEVNQAVASKSASVLVRVLRSMITSTAFQ---------ILVSNNSPIKPITDTSIITLEGVLP 253

  Fly   210 PTESVADGQKLPVILITANLKTFGIYNDYPVNADA-----AVLLVLMELFSKLHYTSSMAPKYRL 269
                 ..|:..|.|:|||:..|||:.......||:     |:||.|:.||.:|:........|.|
Zfish   254 -----GAGEDPPTIVITAHFDTFGLAPWLAYGADSNGSGVAILLELVRLFHRLNSNPRSQAPYHL 313

  Fly   270 RFLLSDAGVLLNFQGSKKWLEVD-DNA-----LQNVEFVLCLDTISESLSYTTENALYMHVSKPP 328
            .|.|:..| ..||.|:|.|||.: |:|     ..|||||:|||::.      |.:.:::|||:||
Zfish   314 LFSLTGGG-KYNFLGTKHWLEENMDHAESSLLHDNVEFVICLDSLG------TGDEIFLHVSRPP 371

  Fly   329 KDKTSISNFFKLLKSSAEKYSNGLAVEGVHKKINLADTKLAWEHERFSIKRYPSFTLSSVKSPRS 393
            |..|...:|.:.|:.........:....|||||||.:|.:||||||:.:||.|.||||.:::|:|
Zfish   372 KPGTPQYSFIQQLEQIISARFPWVRFGTVHKKINLQETNVAWEHERYGMKRIPGFTLSHIENPKS 436

  Fly   394 PIR----TTIFKNDESRLVEHTLNTTRIIAEALASFMYKVDPTSS-----IFEGQLAIKEENILP 449
            .:|    .||.:.|..:|..:|:    |:||:||.|||.:....|     :|:|.|.|::..:..
Zfish   437 ELRGSILDTIAQVDMRKLKRNTV----IVAESLARFMYNLSDKGSAKDMQVFKGSLDIQDSRLSA 497

  Fly   450 YFGV---------------KSILHNNDVKDAFEKYLNNVKIIYDKPDARDPEFMFYNENEVKLNV 499
            ...:               :..|..|.::..|:.||..|.......|.||||..|:::.:..:.:
Zfish   498 LMTMLTSVPRAVQLLDREPEHTLLINSLEQEFKHYLKQVHKHTFHQDRRDPEITFFDQMKQPMMM 562

  Fly   500 YRVKPAIFDLFLTFVIGAYLLAVFLAIQYFPRFYDEVSKLTK 541
            ||||||.|||||...|..||..|:..||.|...|.::....|
Zfish   563 YRVKPAAFDLFLGGCIAGYLGIVYYGIQNFGNVYTKLKASMK 604

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4972	NP_609378.1	M28_nicalin_like	121..429	CDD:193503	103/323 (32%)
zgc:109965	XP_009293490.1	M28_nicalin_like	173..472	CDD:193503	103/323 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170574668
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2526
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	271	1.000	Inparanoid score	I2974
OMA	1	1.010	-	-		QHG60111
OrthoDB	1	1.010	-	-		D355092at33208
OrthoFinder	1	1.000	-	-		FOG0004762
OrthoInspector	1	1.000	-	-		otm25680
orthoMCL	1	0.900	-	-		OOG6_104880
Panther	1	1.100	-	-	O	PTHR31826
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X3350
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	12.810