DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4972 and ncln

DIOPT Version :9

Sequence 1:	NP_609378.1	Gene:	CG4972 / 34388	FlyBaseID:	FBgn0032217	Length:	561	Species:	Drosophila melanogaster
Sequence 2:	NP_001025659.1	Gene:	ncln / 595051	XenbaseID:	XB-GENE-1004030	Length:	560	Species:	Xenopus tropicalis

Alignment Length:	594	Identity:	197/594 - (33%)
Similarity:	292/594 - (49%)	Gaps:	94/594 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MMNEADSLTE-IFRGGLPHCLLIVF--SLLLTCSPVMPS---EFEVISMSKYDLNGQHYGSRVAS 59
            |:.||..:.: :.:...| ...|||  ::||..||:...   ||.|..|..|||.||.||:|.:.
Frog     1 MLEEAGEVFDNMLKASFP-LTFIVFLPAVLLLVSPLQAEAAHEFTVYRMQHYDLQGQSYGTRNSV 64

  Fly    60 ISLEARSLYSWNTSRHCVLTRLTDLSIHDFDK-LRQGAGGLILMLPANILNLDPETKELITILEQ 123
            ::.|||::.:...||.|||.||.|.|...:.| |||.||.::::||.|:..|..:..:....:|.
Frog    65 LNTEARTVQADVLSRRCVLMRLADFSFEQYQKALRQSAGAVVIILPPNMAALPQDIVQQFMDIEP 129

  Fly   124 SMLTHTAAVPIYFAPYNKDLEKIIDDITYTTTDSPGQNQTALAQLVV-TVSANRYHINVGGGSIA 187
            .||:....||:|||..:::|..|.:.   |...|..|..::.|:::: |.:||.:.:...|....
Frog   130 EMLSMETQVPVYFAVEDEELLSIYEQ---TLAASASQGTSSAAEVLLHTATANGFQMVTSGAQSK 191

  Fly   188 ANKNSKIPIIHGELIPNQLALKPTESVADGQKLPVILITANLKTFGIYNDYPVNADA-----AVL 247
            |..:..:..:.|.|           :....:.||.|.|.|:..:||:.......||:     .:|
Frog   192 AVSDWLVTSVEGRL-----------TGLGAEDLPTIAIVAHYDSFGVAPWLSYGADSNGSGVTIL 245

  Fly   248 LVLMELFSKLHYTSSMAPKYRLRFLLSDAGVLLNFQGSKKWLE-----VDDNALQ-NVEFVLCLD 306
            |.|..|||:|:........|.|.|..|..| ..|:||:|:|||     .|.:.|| ||.||||||
Frog   246 LELARLFSRLYTYKRTHAGYNLLFFASGGG-KFNYQGTKRWLEDHLDHTDSSLLQDNVAFVLCLD 309

  Fly   307 TISESLSYTTENALYMHVSKPPKDKTSISNFFKLLKSSAEKYSNGLAVEGVHKKINLADTKLAWE 371
            |:...      :.|::||||||::.|....|.:.|:.........:....||||||||:..||||
Frog   310 TLGNG------DTLHLHVSKPPREGTLQHAFLRELEMIISSQFPEVKFSMVHKKINLAEDTLAWE 368

  Fly   372 HERFSIKRYPSFTLSSVKSPRSPIRTTI----FKNDESRLVEHTLNTTRIIAEALASFMY----K 428
            ||||:|:|.|:||:|.::|.||..|.:|    :|.|...|..:    ||||||||...:|    |
Frog   369 HERFAIRRLPAFTVSHLESHRSGHRNSILDLRWKVDTQVLARN----TRIIAEALTRVIYNLTEK 429

  Fly   429 VDPTS-SIFEGQLAIKEENI--------------------------LPYFGVKSILHNNDVKDAF 466
            ..|:. .||..|:.:::|.:                          |.|:              .
Frog   430 AAPSDLQIFTQQMQVQKEQLDAVMQWLTGQPRAAQLVDKDSSLLSTLEYY--------------M 480

  Fly   467 EKYLNNVKIIYDKPDARDPEFMFYNENEVKLNVYRVKPAIFDLFLTFVIGAYLLAVFLAIQYFPR 531
            .:||.:||..:.|.|.|||||:||::.:..:|.||||||||||.|...|.|||...:.|:|.|..
Frog   481 SRYLKDVKFYHVKADKRDPEFVFYDQLKQTMNAYRVKPAIFDLLLALCIAAYLGLSYFAVQNFGL 545

  Fly   532 FYDEVSKLT 540
            .|..|.:::
Frog   546 LYKLVQRVS 554

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4972	NP_609378.1	M28_nicalin_like	121..429	CDD:193503	110/327 (34%)
ncln	NP_001025659.1	M28_nicalin_like	124..426	CDD:349878	110/326 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H10604
Inparanoid	1	1.050	261	1.000	Inparanoid score	I3022
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D355092at33208
OrthoFinder	1	1.000	-	-		FOG0004762
OrthoInspector	1	1.000	-	-		otm47936
Panther	1	1.100	-	-	LDO	PTHR31826
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3506
SonicParanoid	1	1.000	-	-		X3350
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.190