DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG4972 and Ncln

DIOPT Version :9

Sequence 1:	NP_609378.1	Gene:	CG4972 / 34388	FlyBaseID:	FBgn0032217	Length:	561	Species:	Drosophila melanogaster
Sequence 2:	NP_598770.1	Gene:	Ncln / 103425	MGIID:	1926081	Length:	563	Species:	Mus musculus

Alignment Length:	584	Identity:	206/584 - (35%)
Similarity:	301/584 - (51%)	Gaps:	73/584 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MMNEADSLTE-IFRGGLPHCL---LIVF--SLLLTCSPVMPS-----EFEVISMSKYDLNGQHYG 54
            |:.||..:.| :.:..   ||   .|||  ::||..:|.:|:     ||.|..|.:|||.||.||
Mouse     1 MLEEAGEVLENVLKAS---CLPLGFIVFLPAVLLLVAPPLPAADAAHEFTVYRMQQYDLQGQPYG 62

  Fly    55 SRVASISLEARSLYSWNTSRHCVLTRLTDLSIHDFDK-LRQGAGGLILMLPANILNLDPETKELI 118
            :|.|.::.|||::.:...||.|||.||.|.|...:.| |||.||.::::||..:..:..:.....
Mouse    63 TRNAVLNTEARTVDADVLSRRCVLMRLLDFSYEHYQKALRQSAGAVVIILPRAMAAVPQDVVRQF 127

  Fly   119 TILEQSMLTHTAAVPIYFAPYNKDLEKIIDDITYTTTDSPGQNQTALAQLVV-TVSANRYHINVG 182
            ..:|..||.....||:|||..::.|..|.:.   |...|..|...:.|:::: |.:||.:.:...
Mouse   128 MEIEPEMLAMETVVPVYFAVEDEALLSIYEQ---TQAASASQGSASAAEVLLHTATANGFQMVTS 189

  Fly   183 GGSIAANKNSKIPIIHGELIPNQLALKPTESVADGQKLPVILITANLKTFGIYNDYPVNADA--- 244
            |....|..:..|..:.|.|           :...|:.||.|:|.|:...||:.....:.||:
Mouse   190 GAQSQAVSDWLITSVEGRL-----------TGLGGEDLPTIVIVAHYDAFGVAPWLSLGADSNGS 243

  Fly   245 --AVLLVLMELFSKLHYTSSMAPKYRLRFLLSDAGVLLNFQGSKKWLE-----VDDNALQ-NVEF 301
              :|||.|..|||:|:........|.|.|..|..| ..|:||:|:|||     .|.:.|| ||.|
Mouse   244 GISVLLELARLFSRLYTYKRTHAAYNLLFFASGGG-KFNYQGTKRWLEDSLDHTDSSLLQDNVAF 307

  Fly   302 VLCLDTISESLSYTTENALYMHVSKPPKDKTSISNFFKLLKSSAEKYSNGLAVEGVHKKINLADT 366
            ||||||:...      :.|.:||||||::.|....|.:.|::.|......::...|||||||||.
Mouse   308 VLCLDTVGRG------SHLRLHVSKPPREGTLQHAFLRELETVAAHQFPDVSFSMVHKKINLADD 366

  Fly   367 KLAWEHERFSIKRYPSFTLSSVKSPRSPIRTTIFKNDESRLVEHTL-NTTRIIAEALASFMYKV- 429
            .||||||||:|:|.|:||||.::|.|:..|::|. :..||:...|| ..||||||||...:|.:
Mouse   367 VLAWEHERFAIRRLPAFTLSHLESHRAGPRSSIM-DVRSRVDSKTLTRNTRIIAEALTRVIYNLT 430

  Fly   430 ----DPTSSIFEGQLAIKEENILPYFGVKSILHN---------------NDVKDAFEKYLNNVKI 475
                .|...:|..|:.::||.|   ..|...|.|               :.::....:||.:|:.
Mouse   431 EKGTPPDMPVFTEQMQVQEEQI---DSVMDWLTNQPRAAQLLDKDGTFLSTLEHFLSRYLKDVRQ 492

  Fly   476 IYDKPDARDPEFMFYNENEVKLNVYRVKPAIFDLFLTFVIGAYLLAVFLAIQYFPRFYDEVSKL 539
            .:.|.|.|||||:||::.:..:|.||||||||||.|...|||||...:.|:|:|...|..|.:|
Mouse   493 HHVKADKRDPEFVFYDQLKQVMNAYRVKPAIFDLLLALCIGAYLGMAYTAVQHFHVLYKTVQRL 556

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4972	NP_609378.1	M28_nicalin_like	121..429	CDD:193503	116/320 (36%)
Ncln	NP_598770.1	M28_nicalin_like	130..429	CDD:193503	116/320 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167831614
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2526
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H10604
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2974
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60111
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0004762
OrthoInspector	1	1.000	-	-		oto92646
orthoMCL	1	0.900	-	-		OOG6_104880
Panther	1	1.100	-	-	LDO	PTHR31826
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3506
SonicParanoid	1	1.000	-	-		X3350
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	14	13.790