Protein Alignment CG4972 and Ncln

DIOPT Version :10

• Sequence 1: NP_609378.1
• Gene: CG4972 / 34388
• FlyBaseID: FBgn0032217
• Length: 561
• Species: Drosophila melanogaster
• Sequence 2: NP_598770.1
• Gene: Ncln / 103425
• MGIID: 1926081
• Length: 563
• Species: Mus musculus
• Alignment Length: 584
• Identity: 206/584 - (35%)
• Similarity: 301/584 - (51%)
• Gaps: 73/584 - (12%)

  Fly     1 MMNEADSLTE-IFRGGLPHCL---LIVF--SLLLTCSPVMPS-----EFEVISMSKYDLNGQHYG 54
            |:.||..:.| :.:..   ||   .|||  ::||..:|.:|:     ||.|..|.:|||.||.||
Mouse     1 MLEEAGEVLENVLKAS---CLPLGFIVFLPAVLLLVAPPLPAADAAHEFTVYRMQQYDLQGQPYG 62

  Fly    55 SRVASISLEARSLYSWNTSRHCVLTRLTDLSIHDFDK-LRQGAGGLILMLPANILNLDPETKELI 118
            :|.|.::.|||::.:...||.|||.||.|.|...:.| |||.||.::::||..:..:..:.....
Mouse    63 TRNAVLNTEARTVDADVLSRRCVLMRLLDFSYEHYQKALRQSAGAVVIILPRAMAAVPQDVVRQF 127

  Fly   119 TILEQSMLTHTAAVPIYFAPYNKDLEKIIDDITYTTTDSPGQNQTALAQLVV-TVSANRYHINVG 182
            ..:|..||.....||:|||..::.|..|.:.   |...|..|...:.|:::: |.:||.:.:...
Mouse   128 MEIEPEMLAMETVVPVYFAVEDEALLSIYEQ---TQAASASQGSASAAEVLLHTATANGFQMVTS 189

  Fly   183 GGSIAANKNSKIPIIHGELIPNQLALKPTESVADGQKLPVILITANLKTFGIYNDYPVNADA--- 244
            |....|..:..|..:.|.|           :...|:.||.|:|.|:...||:.....:.||:
Mouse   190 GAQSQAVSDWLITSVEGRL-----------TGLGGEDLPTIVIVAHYDAFGVAPWLSLGADSNGS 243

  Fly   245 --AVLLVLMELFSKLHYTSSMAPKYRLRFLLSDAGVLLNFQGSKKWLE-----VDDNALQ-NVEF 301
              :|||.|..|||:|:........|.|.|..|..| ..|:||:|:|||     .|.:.|| ||.|
Mouse   244 GISVLLELARLFSRLYTYKRTHAAYNLLFFASGGG-KFNYQGTKRWLEDSLDHTDSSLLQDNVAF 307

  Fly   302 VLCLDTISESLSYTTENALYMHVSKPPKDKTSISNFFKLLKSSAEKYSNGLAVEGVHKKINLADT 366
            ||||||:...      :.|.:||||||::.|....|.:.|::.|......::...|||||||||.
Mouse   308 VLCLDTVGRG------SHLRLHVSKPPREGTLQHAFLRELETVAAHQFPDVSFSMVHKKINLADD 366

  Fly   367 KLAWEHERFSIKRYPSFTLSSVKSPRSPIRTTIFKNDESRLVEHTL-NTTRIIAEALASFMYKV- 429
            .||||||||:|:|.|:||||.::|.|:..|::|. :..||:...|| ..||||||||...:|.:
Mouse   367 VLAWEHERFAIRRLPAFTLSHLESHRAGPRSSIM-DVRSRVDSKTLTRNTRIIAEALTRVIYNLT 430

  Fly   430 ----DPTSSIFEGQLAIKEENILPYFGVKSILHN---------------NDVKDAFEKYLNNVKI 475
                .|...:|..|:.::||.|   ..|...|.|               :.::....:||.:|:.
Mouse   431 EKGTPPDMPVFTEQMQVQEEQI---DSVMDWLTNQPRAAQLLDKDGTFLSTLEHFLSRYLKDVRQ 492

  Fly   476 IYDKPDARDPEFMFYNENEVKLNVYRVKPAIFDLFLTFVIGAYLLAVFLAIQYFPRFYDEVSKL 539
            .:.|.|.|||||:||::.:..:|.||||||||||.|...|||||...:.|:|:|...|..|.:|
Mouse   493 HHVKADKRDPEFVFYDQLKQVMNAYRVKPAIFDLLLALCIGAYLGMAYTAVQHFHVLYKTVQRL 556

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG4972	NP_609378.1	M28_nicalin_like	118..429	CDD:349878	116/323 (36%)
Ncln	NP_598770.1	M28_nicalin_like	127..429	CDD:349878	116/323 (36%)