DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp14 and USP14

DIOPT Version :9

Sequence 1:	NP_001260321.1	Gene:	Usp14 / 34387	FlyBaseID:	FBgn0032216	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_005142.1	Gene:	USP14 / 9097	HGNCID:	12612	Length:	494	Species:	Homo sapiens

Alignment Length:	486	Identity:	269/486 - (55%)
Similarity:	350/486 - (72%)	Gaps:	13/486 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPAFKVKVKWGRELYTDIVVNTDEEPILFKAQLFALTGVQPDRQKVMCKGGILKDDQW-NLQIKD 64
            ||.:.|.||||:|.:..:.:||||.|::|||||||||||||.|||||.|||.||||.| |::||:
Human     1 MPLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGNIKIKN 65

  Fly    65 GAVVLLLGSKESVPEVPATPVKFIEDMNEAEAATAMRLPAGLTNLGNTCYMNATVQCLNAVPELR 129
            |..:|::||.:::||.|:....|:|||.|.:.|:||.||.|||||||||||||||||:.:||||:
Human    66 GMTLLMMGSADALPEEPSAKTVFVEDMTEEQLASAMELPCGLTNLGNTCYMNATVQCIRSVPELK 130

  Fly   130 TALSTFSN--DGTDTMSTAFSISSAMKSIFAQMEK-GTTVTPIVLLQALHRASPQFAQTGENGTY 191
            .||..::.  ..:..|::|..|::|::.:|..|:| .:::.||:|||.||.|.||||:.||.|.|
Human   131 DALKRYAGALRASGEMASAQYITAALRDLFDSMDKTSSSIPPIILLQFLHMAFPQFAEKGEQGQY 195

  Fly   192 RQQDANECWAEILKMLQQKL---------RPKNQEPSNTVQKRHSSFIDQFFGGTFEVKMSSEED 247
            .||||||||.:::::|||||         ...:...|.....:..|.||||||..||..|...|.
Human   196 LQQDANECWIQMMRVLQQKLEAIEDDSVKETDSSSASAATPSKKKSLIDQFFGVEFETTMKCTES 260

  Fly   248 PDEPSTVTSENFLQLSCFISMDVKYMQSGLKSKMKEQLVKKSETLGRDAKYIRTYLVSRLPAYLT 312
            .:|..|...||.|||||||:.:|||:.:|||.:::|::.|:|.||.|:|.||::..:||||||||
Human   261 EEEEVTKGKENQLQLSCFINQEVKYLFTGLKLRLQEEITKQSPTLQRNALYIKSSKISRLPAYLT 325

  Fly   313 VQFVRFQYKGKEGINAKVLKDIKFPIDFDAFELCTPELQNKLCPMRSKFKDLEDKKMEVDVVKRN 377
            :|.|||.||.||.:|||||||:|||:..|.:||||||||.|:...|||||||||||:.......:
Human   326 IQMVRFFYKEKESVNAKVLKDVKFPLMLDMYELCTPELQEKMVSFRSKFKDLEDKKVNQQPNTSD 390

  Fly   378 EPNEEKKDVKYEQFWFDDDLGSNNSGYYTLQAVLTHKGRSSSSGHYVAWVRSSGDVWFKFDDDEV 442
            :.:..:|:||||.|.|.||:||||.|||.|||||||:||||||||||:||:...|.|.|||||:|
Human   391 KKSSPQKEVKYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSGHYVSWVKRKQDEWIKFDDDKV 455

  Fly   443 SAVATDEILRLSGGGDWHCAYVLLYAPRRLE 473
            |.|..::|||||||||||.||||||.|||:|
Human   456 SIVTPEDILRLSGGGDWHIAYVLLYGPRRVE 486

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp14	NP_001260321.1	UBQ	4..73	CDD:214563	42/69 (61%)
		UBQ	5..73	CDD:294102	42/68 (62%)
		UCH	103..467	CDD:278850	205/375 (55%)
		Peptidase_C19A	105..467	CDD:239122	204/373 (55%)
USP14	NP_005142.1	Ubl_USP14_like	4..76	CDD:340521	44/71 (62%)
USP14	NP_005142.1	Peptidase_C19A	106..481	CDD:239122	205/374 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165146283
Domainoid	1	1.000	411	1.000	Domainoid score	I682
eggNOG	1	0.900	-	-		E1_KOG1872
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3780
Inparanoid	1	1.050	543	1.000	Inparanoid score	I1178
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53846
OrthoDB	1	1.010	-	-		D274769at33208
OrthoFinder	1	1.000	-	-		FOG0003772
OrthoInspector	1	1.000	-	-		oto90326
orthoMCL	1	0.900	-	-		OOG6_101892
Panther	1	1.100	-	-	LDO	PTHR43982
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2630
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	15	14.770