DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp14 and Usp14

DIOPT Version :9

Sequence 1:	NP_001260321.1	Gene:	Usp14 / 34387	FlyBaseID:	FBgn0032216	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_067497.2	Gene:	Usp14 / 59025	MGIID:	1928898	Length:	493	Species:	Mus musculus

Alignment Length:	487	Identity:	273/487 - (56%)
Similarity:	352/487 - (72%)	Gaps:	16/487 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPAFKVKVKWGRELYTDIVVNTDEEPILFKAQLFALTGVQPDRQKVMCKGGILKDDQW-NLQIKD 64
            ||.:.|.||||:|.:..:.:||||.|::|||||||||||||.|||||.|||.||||.| |:::|:
Mouse     1 MPLYSVTVKWGKEKFEGVELNTDEPPMVFKAQLFALTGVQPARQKVMVKGGTLKDDDWGNIKMKN 65

  Fly    65 GAVVLLLGSKESVPEVPATPVKFIEDMNEAEAATAMRLPAGLTNLGNTCYMNATVQCLNAVPELR 129
            |..||::||.:::||.|:....|:|||.|.:.||||.||.|||||||||||||||||:.:||||:
Mouse    66 GMTVLMMGSADALPEEPSAKTVFVEDMTEEQLATAMELPCGLTNLGNTCYMNATVQCIRSVPELK 130

  Fly   130 TALSTFSN--DGTDTMSTAFSISSAMKSIFAQMEK-GTTVTPIVLLQALHRASPQFAQTGENGTY 191
            .||..::.  ..:..|::|..|::|::.:|..|:| .:::.||:|||.||.|.||||:.||.|.|
Mouse   131 DALKRYAGALRASGEMASAQYITAALRDLFDSMDKTSSSIPPIILLQFLHMAFPQFAEKGEQGQY 195

  Fly   192 RQQDANECWAEILKMLQQKLR----------PKNQEPSNTVQKRHSSFIDQFFGGTFEVKMSSEE 246
            .||||||||.:::::|||||.          ..:..|:.|..|: .|.|||:||..||..|...|
Mouse   196 LQQDANECWIQMMRVLQQKLEAIEDDSGRETDSSSAPAVTPSKK-KSLIDQYFGVEFETTMKCTE 259

  Fly   247 DPDEPSTVTSENFLQLSCFISMDVKYMQSGLKSKMKEQLVKKSETLGRDAKYIRTYLVSRLPAYL 311
            ..:|..|...||.|||||||:.:|||:.:|||.:::|::.|:|.||.|:|.||::..:|||||||
Mouse   260 SEEEEVTKGKENQLQLSCFINQEVKYLFTGLKLRLQEEITKQSPTLQRNALYIKSSKISRLPAYL 324

  Fly   312 TVQFVRFQYKGKEGINAKVLKDIKFPIDFDAFELCTPELQNKLCPMRSKFKDLEDKKMEVDVVKR 376
            |:|.|||.||.||.:|||||||:|||:..|.:||||||||.|:...|||||||||||:. .....
Mouse   325 TIQMVRFFYKEKESVNAKVLKDVKFPLMLDVYELCTPELQEKMVSFRSKFKDLEDKKVN-QQPNA 388

  Fly   377 NEPNEEKKDVKYEQFWFDDDLGSNNSGYYTLQAVLTHKGRSSSSGHYVAWVRSSGDVWFKFDDDE 441
            |:.|...|::|||.|.|.||:||||.|||.|||||||:||||||||||:|||...|.|.|||||:
Mouse   389 NDKNSPPKEIKYEPFSFADDIGSNNCGYYDLQAVLTHQGRSSSSGHYVSWVRRKQDEWIKFDDDK 453

  Fly   442 VSAVATDEILRLSGGGDWHCAYVLLYAPRRLE 473
            ||.|..::|||||||||||.||||||.|||:|
Mouse   454 VSIVTPEDILRLSGGGDWHIAYVLLYGPRRVE 485

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp14	NP_001260321.1	UBQ	4..73	CDD:214563	42/69 (61%)
		UBQ	5..73	CDD:294102	42/68 (62%)
		UCH	103..467	CDD:278850	208/376 (55%)
		Peptidase_C19A	105..467	CDD:239122	207/374 (55%)
Usp14	NP_067497.2	UBQ	5..74	CDD:214563	43/69 (62%)
		UBQ	5..74	CDD:294102	43/69 (62%)
		UCH	104..479	CDD:278850	213/383 (56%)
		Peptidase_C19A	106..480	CDD:239122	212/381 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836373
Domainoid	1	1.000	412	1.000	Domainoid score	I683
eggNOG	1	0.900	-	-		E1_KOG1872
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3780
Inparanoid	1	1.050	544	1.000	Inparanoid score	I1148
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53846
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0003772
OrthoInspector	1	1.000	-	-		oto93909
orthoMCL	1	0.900	-	-		OOG6_101892
Panther	1	1.100	-	-	LDO	PTHR43982
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1592
SonicParanoid	1	1.000	-	-		X2630
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.790