DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp14 and usp14

DIOPT Version :9

Sequence 1:	NP_001260321.1	Gene:	Usp14 / 34387	FlyBaseID:	FBgn0032216	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_001005641.1	Gene:	usp14 / 448110	XenbaseID:	XB-GENE-971842	Length:	490	Species:	Xenopus tropicalis

Alignment Length:	484	Identity:	268/484 - (55%)
Similarity:	350/484 - (72%)	Gaps:	13/484 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPAFKVKVKWGRELYTDIVVNTDEEPILFKAQLFALTGVQPDRQKVMCKGGILKDDQW-NLQIKD 64
            ||.:.|.||||:|.:.::.:||||.|::|||||||||||||||||||.|||.||||.| .|:||.
Frog     1 MPLYSVNVKWGKEKFDNVELNTDEPPMVFKAQLFALTGVQPDRQKVMVKGGTLKDDDWGTLKIKS 65

  Fly    65 GAVVLLLGSKESVPEVPATPVKFIEDMNEAEAATAMRLPAGLTNLGNTCYMNATVQCLNAVPELR 129
            |..:|::||.|::||.||....|:|||.|.:.|:||.||.|||||||||||||||||:.:||||:
Frog    66 GMTLLMMGSAEALPEEPAVRPVFVEDMTEEQLASAMELPCGLTNLGNTCYMNATVQCIRSVPELK 130

  Fly   130 TALSTFSN--DGTDTMSTAFSISSAMKSIFAQMEK-GTTVTPIVLLQALHRASPQFAQTGENGTY 191
            .||..::.  ..:..|::|..|::|::.:|..|:| .:::.||:|||.||.|.||||:.|:.|.|
Frog   131 EALKRYAGALRASGEMASAQYITAALRDLFDSMDKTSSSIPPIILLQFLHMAFPQFAEKGDQGQY 195

  Fly   192 RQQDANECWAEILKMLQQKLRP-------KNQEPSNTVQKRHSSFIDQFFGGTFEVKMSSEEDPD 249
            .||||||||.:::::|||||..       :....:.....:.:||||||||..||..|...|..|
Frog   196 LQQDANECWVQVMRVLQQKLEAIEGDSDMETDSGAAATASKKNSFIDQFFGIEFESTMKCTESED 260

  Fly   250 EPSTVTSENFLQLSCFISMDVKYMQSGLKSKMKEQLVKKSETLGRDAKYIRTYLVSRLPAYLTVQ 314
            |..|.:.|..|||||||:.:|||:.:|||.:::|::.|.|.:|.|:|.||:|..:||||||||:|
Frog   261 EEVTKSKETQLQLSCFINQEVKYLFTGLKLRLQEEITKFSPSLQRNALYIKTSRISRLPAYLTIQ 325

  Fly   315 FVRFQYKGKEGINAKVLKDIKFPIDFDAFELCTPELQNKLCPMRSKFKDLEDKKMEVDVVKRNEP 379
            .|||.||.||.:|||||||:|||:..|.:||||||||.|:...|||||.|||||......|.|:.
Frog   326 MVRFFYKEKESVNAKVLKDVKFPLMLDIYELCTPELQEKMVSYRSKFKQLEDKKGSEQAPKANQM 390

  Fly   380 NEEKKDVKYEQFWFDDDLGSNNSGYYTLQAVLTHKGRSSSSGHYVAWVRSSGDVWFKFDDDEVSA 444
            ::  ::|:||.:.|..|:||.|||||.|||||||:||||||||||:||:...|.|.|||||:||.
Frog   391 SQ--REVRYEPYAFPGDVGSINSGYYELQAVLTHQGRSSSSGHYVSWVKRKHDEWIKFDDDKVSI 453

  Fly   445 VATDEILRLSGGGDWHCAYVLLYAPRRLE 473
            |:.::|||||||||||.||||||.|||:|
Frog   454 VSPEDILRLSGGGDWHIAYVLLYGPRRIE 482

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp14	NP_001260321.1	UBQ	4..73	CDD:214563	43/69 (62%)
		UBQ	5..73	CDD:294102	43/68 (63%)
		UCH	103..467	CDD:278850	201/373 (54%)
		Peptidase_C19A	105..467	CDD:239122	200/371 (54%)
usp14	NP_001005641.1	Ubl_USP14_like	4..76	CDD:340521	45/71 (63%)
usp14	NP_001005641.1	Peptidase_C19A	106..477	CDD:239122	201/372 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	401	1.000	Domainoid score	I722
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3780
Inparanoid	1	1.050	532	1.000	Inparanoid score	I1189
OMA	1	1.010	-	-		QHG53846
OrthoDB	1	1.010	-	-		D274769at33208
OrthoFinder	1	1.000	-	-		FOG0003772
OrthoInspector	1	1.000	-	-		oto104131
Panther	1	1.100	-	-	LDO	PTHR43982
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1592
SonicParanoid	1	1.000	-	-		X2630
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110