DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp14 and Usp8

DIOPT Version :9

Sequence 1:	NP_001260321.1	Gene:	Usp14 / 34387	FlyBaseID:	FBgn0032216	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_650948.2	Gene:	Usp8 / 42509	FlyBaseID:	FBgn0038862	Length:	896	Species:	Drosophila melanogaster

Alignment Length:	541	Identity:	110/541 - (20%)
Similarity:	178/541 - (32%)	Gaps:	220/541 - (40%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 DRQKVMCKGGILKDDQWNLQIKDGAVVLLLGS------KESVPEVPATPVKFIEDM--------- 91
            :||::        |:|..|:.::...:|.:..      |...|..|.:|.:.:||:
  Fly   451 ERQRL--------DEQHELERQERERLLAIARETKKHYKSPTPSGPPSPGRNLEDVHVVSDSLES 507

  Fly    92 --------------NEAEAAT---AMRLP---------------------------AGLTNLGNT 112
                          |:||..|   ||: |                           .||.|||||
  Fly   508 LLQLTGDPDPTIAPNKAEIPTFDRAMK-PQPRNVERTSQRVRDFSPVIGQNVGRGLTGLKNLGNT 571

  Fly   113 CYMNATVQCLNAVPELRTALSTFSNDGTDTMSTAFSISSAMKSIFAQMEK--GTTVTPI-VLLQA 174
            ||||:.:|||:..|:|                |.:.||...|:..::..|  |..:..: .|::.
  Fly   572 CYMNSILQCLSNTPQL----------------TEYCISDKYKNYISRSNKTNGQVIEEVAALIKE 620

  Fly   175 LHRASPQFAQTGENGTYR----------------------QQDANECWAEILKMLQQKLR----P 213
            |.           ||.|:                      |||::|....::..|...|:    |
  Fly   621 LW-----------NGQYKCVASRDLRYVVGQYQKIFRGVDQQDSHEFLTILMDWLHSDLQTLHVP 674

  Fly   214 KNQEPSNTVQK--------RHSSFIDQFFGGTFEVKMSSEEDPDEPSTVTSENFLQLS------- 263
            :.:|..:..:|        :.|..:..|:|   ::|.:.:.......:.|.|:|..||
  Fly   675 RQREMISASEKAWLEFTKAKESMILHLFYG---QMKSTVKCVACHKESATYESFSNLSLELPPNS 736

  Fly   264 --CFISMDVKYMQSGLK--------SKMKEQLVKKSETLGRDAKYIRTYLVSRLPAYLTVQFVRF 318
              |.::..:....||.:        .|.|...:||.:             :|:||..|.|...||
  Fly   737 NVCQLNQCMDMYFSGERIHGWNCPSCKTKRDAIKKLD-------------ISKLPPVLVVHLKRF 788

  Fly   319 QY-KGKEGINAKVLKDIKFPIDFDAFELCTPELQNKLCPMRSKFKDLEDKKMEVDVVKRNEPNEE 382
            .. ....|...|....::||                          ||:..|...:.:.......
  Fly   789 YADPSNSGSYMKKQNYLRFP--------------------------LENLDMNPYIARAESRAVT 827

  Fly   383 KKDVKYEQFWFDDDLGSNNSGYYTLQAVLTHKGRSSSSGHYVAWVRSSG-DVWFKFDDDEVSAVA 446
            .|.                   |.|.||..|.| :...|||.|:.:|:. ..||||||..|||:.
  Fly   828 PKT-------------------YQLYAVSNHYG-TMEGGHYTAFCKSANYGKWFKFDDQVVSALD 872

  Fly   447 TDEILRLSGGGDWHCAYVLLY 467
            :..::.       ..||:|.|
  Fly   873 SSNVVS-------SAAYILFY 886

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp14	NP_001260321.1	UBQ	4..73	CDD:214563	6/30 (20%)
		UBQ	5..73	CDD:294102	6/30 (20%)
		UCH	103..467	CDD:278850	91/446 (20%)
		Peptidase_C19A	105..467	CDD:239122	90/417 (22%)
Usp8	NP_650948.2	USP8_dimer	2..113	CDD:286108
		RHOD	148..278	CDD:294087
		UCH	562..886	CDD:278850	90/419 (21%)
		Peptidase_C19R	564..887	CDD:239139	91/419 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456851
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840