DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp14 and Usp2

DIOPT Version :9

Sequence 1:	NP_001260321.1	Gene:	Usp14 / 34387	FlyBaseID:	FBgn0032216	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_001285528.1	Gene:	Usp2 / 33132	FlyBaseID:	FBgn0031187	Length:	950	Species:	Drosophila melanogaster

Alignment Length:	400	Identity:	94/400 - (23%)
Similarity:	153/400 - (38%)	Gaps:	115/400 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   105 GLTNLGNTCYMNATVQCLNAVPELRTALSTFSNDGTDTMSTAFSISSAMKSIFAQM--EKGT--- 164
            ||.|:||||:||:.:|||:...||...|.  |:.|:.::||.   ...:...||::  |..|
  Fly   626 GLRNIGNTCFMNSVIQCLSHTQELTRFLR--SHHGSRSLSTK---DQQILHEFAKLIQEMWTANV 685

  Fly   165 -TVTPIVLLQALHRASPQFAQTGENGTYRQQDANECWAEILKMLQQKLR--------------PK 214
             ||||:.|.:|.......::.      |.||||.|.....|..|...|.              ..
  Fly   686 HTVTPMELKRAFSTKHRMYSD------YNQQDAQEFLRFFLDSLHSALNSGVKGETLNIDDNLSD 744

  Fly   215 NQEPSNTVQ--KRH-SSFIDQFFGGTFEVKMSSEEDPDEPSTVTSENFLQLSCFISMDVKYMQSG 276
            |::...|.:  .|| :|.:...|.|  ::|.:.:......::||.:.|..||.       .:.|.
  Fly   745 NKKADLTWEWYTRHENSLVRDLFVG--QLKSTLKCTTCGNTSVTFDPFWDLSV-------PLPSS 800

  Fly   277 LKSKMKE--QLVKKSETLGRD-----------AKYIRTYLVSRLPAYLTVQFVRFQYKGKEGINA 328
            .:.|::.  .|..:.|.|..|           .|..:::.:.|.|.||.:...||    .|...:
  Fly   801 SRCKLEACLDLFIREEVLDGDEMPTCAKCKTRRKCTKSFTIQRFPKYLVIHLKRF----SETRWS 861

  Fly   329 KVLKDIKFPIDFDAFELCTPELQNKLCPMRSKFKDLEDKKMEVDVVKRNEPNEEKKDVKYEQFWF 393
            |:...::||                          ..|.::.:.....|
  Fly   862 KLSNIVEFP--------------------------TSDSELNMGSYGAN---------------- 884

  Fly   394 DDDLGSNNSGYYTLQAVLTHKGRSSSSGHYVAWVRSS-GDVWFKFDDDEVSAVATDEILRLSGGG 457
                 ||::.:|:|.|:..|.| |::.|||||..:.. ...|.:|:|:.||...::..|..|.
  Fly   885 -----SNSNVHYSLYAISNHMG-STAGGHYVALCKHPVSRKWHEFNDNIVSDALSENHLVSSS-- 941

  Fly   458 DWHCAYVLLY 467
                ||:|.|
  Fly   942 ----AYILFY 947

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp14	NP_001260321.1	UBQ	4..73	CDD:214563
		UBQ	5..73	CDD:294102
		UCH	103..467	CDD:278850	93/398 (23%)
		Peptidase_C19A	105..467	CDD:239122	93/398 (23%)
Usp2	NP_001285528.1	UCH	624..947	CDD:278850	93/398 (23%)
Usp2	NP_001285528.1	Peptidase_C19R	626..948	CDD:239139	93/399 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45456907
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840