DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Usp14 and ubp6

DIOPT Version :9

Sequence 1:	NP_001260321.1	Gene:	Usp14 / 34387	FlyBaseID:	FBgn0032216	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_594117.2	Gene:	ubp6 / 2541819	PomBaseID:	SPAC6G9.08	Length:	468	Species:	Schizosaccharomyces pombe

Alignment Length:	483	Identity:	185/483 - (38%)
Similarity:	272/483 - (56%)	Gaps:	46/483 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 VKVKWGRELYTDIVVNTDEEPILFKAQLFALTGVQPDRQKVMCKGGILKDD--QWNLQIKDGAVV 68
            :.::|..:.| |:.:..:|.....|.||::||.|.|:||||:.|||.||||  ..::.||..|.:
pombe     5 IAIRWQGKKY-DLEIEPNETGSTLKHQLYSLTQVPPERQKVIVKGGQLKDDVLLGSVGIKPNATL 68

  Fly    69 LLLGSKESVPEVPATPVKFIEDMNEAEAATAMRLPAGLTNLGNTCYMNATVQCLNAVPELRTALS 133
            |::|:...:|  .|.|:..:|.: |.|.:.....|:||.|||||||||:|||.|.|:|||..|:|
pombe    69 LMMGTAGELP--TAMPIPAVESV-EQEESEDDGYPSGLINLGNTCYMNSTVQMLRAIPELSDAVS 130

  Fly   134 TFSNDGTDTMSTAFSISSAMKSIFAQMEKGTTVTPIVLLQALHRASPQFAQ-TGENGTYRQQDAN 197
            .|::.|        .:.:..:::...|:....|||:..||:|....||||: :.|.|.|.||||.
pombe   131 QFNSSG--------GLVAEYRTLLNSMQSNAPVTPMRFLQSLRMEYPQFAEMSRETGGYAQQDAE 187

  Fly   198 ECWAEILKMLQQKLRPKNQEPSNTVQKRHSSFIDQFFGGTFEVKMSSEEDPDEPSTVTSENFLQL 262
            |||:.:|.:||:.|      .|..|||..:       |.........|.:..|..:::.:.||.|
pombe   188 ECWSFLLSVLQRSL------SSEWVQKNMA-------GKLLSTMKCDENEVQEQPSISHDTFLSL 239

  Fly   263 SCFISMDVKYMQSGLKSKMKEQLVKKSETLGRDAKYIRTYLVSRLPAYLTVQFVRFQYKGKEGIN 327
            .|.|||...||..|:...:.:::.|.|:.|.|||.|.:...:||||.||||.||||.:|...|..
pombe   240 PCHISMHTSYMTQGILEGLTQKISKHSDVLNRDAMYSKISRISRLPNYLTVNFVRFYWKASIGKK 304

  Fly   328 AKVLKDIKFPIDFDAFELCTPELQNKLCPMRSKFKDLEDKKMEVDVVKRN---EPNEEKKDVKYE 389
            ||:|:.:|||.:.||.|.|||||..||.|:|.|.:::|....|.:...:.   :|:|::|:.:.|
pombe   305 AKILRKVKFPFELDAVEFCTPELSQKLIPVRDKLREIEKNDEEHERAAKRIKIQPSEDEKEAEAE 369

  Fly   390 ---------QFWFD----DDLGSNNSGYYTLQAVLTHKGRSSSSGHYVAWVRSSGD--VWFKFDD 439
                     |...|    ||.|:|.:|.|.|..||:|.|.|:|||||.||:|:|.:  .||:|:|
pombe   370 CRLTQVATCQSLVDPELADDEGANPTGLYDLVGVLSHAGASASSGHYQAWIRNSNNRAEWFRFND 434

  Fly   440 DEVSAVATDEILRLSGGGDWHCAYVLLY 467
            .:||.|..::|..|.|||:...||:|||
pombe   435 AKVSIVPAEKIETLDGGGEADSAYILLY 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp14	NP_001260321.1	UBQ	4..73	CDD:214563	26/68 (38%)
		UBQ	5..73	CDD:294102	26/68 (38%)
		UCH	103..467	CDD:278850	150/382 (39%)
		Peptidase_C19A	105..467	CDD:239122	149/380 (39%)
ubp6	NP_594117.2	UBQ	3..73	CDD:214563	26/68 (38%)
		ubiquitin	10..72	CDD:278661	25/62 (40%)
		UCH	100..462	CDD:278850	150/382 (39%)
		Peptidase_C19A	102..463	CDD:239122	151/382 (40%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	1	1.000	262	1.000	Domainoid score	I364
eggNOG	1	0.900	-	-		E1_KOG1872
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3780
Inparanoid	1	1.050	309	1.000	Inparanoid score	I582
OMA	1	1.010	-	-		QHG53846
OrthoFinder	1	1.000	-	-		FOG0003772
OrthoInspector	1	1.000	-	-		oto101428
orthoMCL	1	0.900	-	-		OOG6_101892
Panther	1	1.100	-	-	LDO	PTHR43982
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1592
SonicParanoid	1	1.000	-	-		X2630
TreeFam	1	0.960	-	-
	14	13.860