DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Usp14 and usp-14

DIOPT Version :9

Sequence 1:	NP_001260321.1	Gene:	Usp14 / 34387	FlyBaseID:	FBgn0032216	Length:	475	Species:	Drosophila melanogaster
Sequence 2:	NP_497006.1	Gene:	usp-14 / 175105	WormBaseID:	WBGene00006856	Length:	489	Species:	Caenorhabditis elegans

Alignment Length:	492	Identity:	192/492 - (39%)
Similarity:	276/492 - (56%)	Gaps:	48/492 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MPAFKVKVKWGRELYTDIVVNTDEEPILFKAQLFALTGVQPDRQKVMCKGGILKDDQW-NLQIKD 64
            ||.  |.|||.:|.|. :.|:|...|::|||||||||.|.|:||||:..|..|.||.| .:.||:
Worm     1 MPI--VNVKWQKEKYV-VEVDTSAPPMVFKAQLFALTQVVPERQKVVIMGRTLGDDDWEGITIKE 62

  Fly    65 GAVVLLLGSKESVPEVPATPVKFIEDMN---EAEAATAMRLPAGLTNLGNTCYMNATVQCLNAVP 126
            ...::::||...:|:.|....|  :..|   :||..:|: .|.||.|||||||.|:.||.|..|.
Worm    63 NMTIMMMGSVGEIPKPPTVLEK--KQANRDKQAEEISAL-YPCGLANLGNTCYFNSCVQMLKEVN 124

  Fly   127 E--LRTALSTFSNDGTD----TMSTAFSISSAMKSIFAQMEKGTTVTPIVLLQALHRASPQFAQT 185
            |  |:.|......:..|    .::|.|  :|......|...||..:.|...:..|..:.|||.:
Worm   125 ELVLKPAEEMRIREHNDRLCHNLATLF--NSLRDKDRALRSKGEPIKPFAAILTLSDSFPQFEK- 186

  Fly   186 GENGTYRQQDANECWAEILKMLQQKLRPKNQEPSNTVQKRHSS--FIDQFFGGTFEVKMSSEEDP 248
                 ::|||||||...|:              ||..:....|  .|:..|....|..|...|.
Worm   187 -----FKQQDANECLVSIM--------------SNVTRIYGLSGWNIESLFRIQTETTMKCLES- 231

  Fly   249 DEPSTVTSENFLQLSCFISMDVKYMQSGLKSKMKEQLVKKSETLGRDAKYIRTYLVSRLPAYLTV 313
            ||.|....|...||:|:::.||:::|:|:|:..:|::.:.||.|.||||:.:...:||||.||||
Worm   232 DEVSEKKVERNNQLTCYVNQDVRFLQTGIKAGFEEEMTRNSEELNRDAKWQKNTQISRLPKYLTV 296

  Fly   314 QFVRFQYKGKEGINAKVLKDIKFPIDFDAFELCTPELQNKLCPMRSKFKDLEDKKMEVDVVKRNE 378
            ...||.||.....|||:||.::||:..|.::||:.||::||...|:..|..||.|:|.: :::..
Worm   297 NINRFFYKESTKTNAKILKSVQFPMQLDTYDLCSQELKDKLVARRADIKLEEDAKLERE-LRKKV 360

  Fly   379 PNEEKKDVKYEQ-----FWFDDDLGSNNSGYYTLQAVLTHKGRSSSSGHYVAWVRSSGD-VWFKF 437
            .::|:.|..::.     ..|:||.||||||:|.|:.::|||||||..||||||:|||.| .|..|
Worm   361 LDKEQGDKIFDDGVALPTAFEDDAGSNNSGFYDLKGIITHKGRSSQDGHYVAWMRSSEDGKWRLF 425

  Fly   438 DDDEVSAVATDEILRLSGGGDWHCAYVLLYAPRRLEK 474
            ||:.|:.|..:.||:.|||||||.||||||..|.:::
Worm   426 DDEHVTVVDEEAILKTSGGGDWHSAYVLLYEARVIKQ 462

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Usp14	NP_001260321.1	UBQ	4..73	CDD:214563	31/69 (45%)
		UBQ	5..73	CDD:294102	31/68 (46%)
		UCH	103..467	CDD:278850	147/377 (39%)
		Peptidase_C19A	105..467	CDD:239122	146/375 (39%)
usp-14	NP_497006.1	UBQ	1..71	CDD:294102	33/72 (46%)
		UBQ	4..71	CDD:214563	31/67 (46%)
		UCH	101..455	CDD:278850	147/377 (39%)
		Peptidase_C19A	103..456	CDD:239122	147/376 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160158879
Domainoid	1	1.000	239	1.000	Domainoid score	I1270
eggNOG	1	0.900	-	-		E1_KOG1872
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H3780
Inparanoid	1	1.050	303	1.000	Inparanoid score	I1608
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53846
OrthoDB	1	1.010	-	-		D274769at33208
OrthoFinder	1	1.000	-	-		FOG0003772
OrthoInspector	1	1.000	-	-		oto19234
orthoMCL	1	0.900	-	-		OOG6_101892
Panther	1	1.100	-	-	LDO	PTHR43982
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R1592
SonicParanoid	1	1.000	-	-		X2630
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	16	15.840