Protein Alignment Cdk5alpha and cdk5r1a

DIOPT Version :10

• Sequence 1: NP_523535.2
• Gene: Cdk5alpha / 34385
• FlyBaseID: FBgn0027491
• Length: 472
• Species: Drosophila melanogaster
• Sequence 2: NP_001122214.1
• Gene: cdk5r1a / 568402
• ZFINID: ZDB-GENE-080723-17
• Length: 306
• Species: Danio rerio
• Alignment Length: 352
• Identity: 133/352 - (37%)
• Similarity: 184/352 - (52%)
• Gaps: 76/352 - (21%)

  Fly   120 SVLKAEKSSFEKNLKKHSIFINALSWKKLSTSHNKKKIENKNKCANLPTACFKAQLLESSFASSS 184
            :.::..|::.:|.||:.|: ||.|.||::..:..|:|...|     ||               |.
Zfish    28 TAVQNSKNAKDKGLKRQSL-INVLPWKRIVAASAKRKGSKK-----LP---------------SG 71

  Fly   185 DKNRNIQLHCNRIDEHNQQHCNQHPHPHPHQHQLQLQNQHQHQNQNQNQNQNQVQDIREEVMTGP 249
            |..          ||......|                     :||..::|:         ....
Zfish    72 DSQ----------DEECVGTLN---------------------SQNLKKSQS---------CANL 96

  Fly   250 PGKSQNPSKAKDPVKVNNKNSMSNHNKLIQKQPLTLSLPQQVQASSIQTKNTNQIPRKTVIQAST 314
            .|.:|.|:.:..|......|..|.    .::.|:|..:.|...|.:         |::.::||||
Zfish    97 SGFTQEPAVSSIPTSKTTTNVTST----AKRTPITELVAQATNAGT---------PKRVIVQAST 148

  Fly   315 SELLKCLGMFLHCRCQRLNNFDAGDAVMWLRAVDRSLLLQGWQDVAFINPANVVFVYMLVRELVS 379
            .|||:.||.||..||.||..|...:.::|||.||||||||||||..||.|||:||:|||.||::|
Zfish   149 CELLRNLGDFLSRRCYRLKRFSPAEPIVWLRQVDRSLLLQGWQDQGFITPANLVFLYMLCREVIS 213

  Fly   380 GEESKESDLQASVLTCLYLSYSYMGNEISYPLKPFLVEDSKEKFWDRCLVIVNKLSDKMLKINAE 444
            .|.|.|.:|||.||||||||||||||||||||||||||..|:.||:|.|.|:|::|.|||::|::
Zfish   214 PEVSSERELQAEVLTCLYLSYSYMGNEISYPLKPFLVEMDKDVFWNRSLDIINRMSGKMLQLNSD 278

  Fly   445 PGFFTEVFTELKSCGQYHPTIKSYCGG 471
            |.:||:||.:||:  :...||...|.|
Zfish   279 PHYFTQVFADLKN--EREITISQLCIG 303

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk5alpha	NP_523535.2	CDK5_activator	96..461	CDD:460866	129/340 (38%)
cdk5r1a	NP_001122214.1	CDK5_activator	21..292	CDD:460866	129/339 (38%)