Protein Alignment Cdk5alpha and Cdk5r2

DIOPT Version :9

• Sequence 1: NP_001260320.1
• Gene: Cdk5alpha / 34385
• FlyBaseID: FBgn0027491
• Length: 472
• Species: Drosophila melanogaster
• Sequence 2: NP_001102779.1
• Gene: Cdk5r2 / 501164
• RGDID: 1562530
• Length: 368
• Species: Rattus norvegicus
• Alignment Length: 350
• Identity: 127/350 - (36%)
• Similarity: 169/350 - (48%)
• Gaps: 89/350 - (25%)

  Fly   130 EKNLKKHSIFINALSWKKLSTSHNKKKIENKNKCANLPTACFKAQLLESSFASSSDKNRNIQLHC 194
            |..||:.|:.|:||:||:|..:..||| :...|....|             ||:.
  Rat    51 ESRLKRPSVLISALTWKRLVAASAKKK-KGSKKVTPKP-------------ASTG---------- 91

  Fly   195 NRIDEHNQQHCNQHPHPHPHQHQLQLQNQHQHQNQNQNQNQNQVQDIREEVMT------------ 247
                            |.|...|...:|. ..:.::........:.:...|.|
  Rat    92 ----------------PDPLVQQRNRENL-LRKGRDAPDGGGAAKPLAVPVPTVPASAATCEPPS 139

  Fly   248 ------GPPGKSQNPSKAKDPVKVNNKNSMSNHNKLIQKQPLTLSLPQQVQASSIQTKNTNQIPR 306
                  .|||..........|                   |...:.|.....|          ||
  Rat   140 GGSAAAPPPGSGGGKPPPPPP-------------------PAPQAAPPAPGGS----------PR 175

  Fly   307 KTVIQASTSELLKCLGMFLHCRCQRLNNFDAGDAVMWLRAVDRSLLLQGWQDVAFINPANVVFVY 371
            :.::||||.|||:|||.|:..||.||.....|:.|.|.|.||||||||||||.|||.|||:||||
  Rat   176 RVIVQASTGELLRCLGDFVCRRCYRLKELSPGELVGWFRGVDRSLLLQGWQDQAFITPANLVFVY 240

  Fly   372 MLVRELVSGEE-SKESDLQASVLTCLYLSYSYMGNEISYPLKPFLVEDSKEKFWDRCLVIVNKLS 435
            :|.||.:.|:| :..::|||:.||||||:||||||||||||||||||..||:||.|||.::.:||
  Rat   241 LLCRESLRGDELASAAELQAAFLTCLYLAYSYMGNEISYPLKPFLVEPDKERFWQRCLRLIQRLS 305

  Fly   436 DKMLKINAEPGFFTEVFTELKSCGQ 460
            .:||::||:|.|||:||.:||:.|:
  Rat   306 PQMLRLNADPHFFTQVFQDLKNEGE 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk5alpha	NP_001260320.1	CDK5_activator	107..458	CDD:281279	126/346 (36%)
Cdk5r2	NP_001102779.1	CDK5_activator	<174..329	CDD:397388	96/154 (62%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166351397
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3932
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3298
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1492547at2759
OrthoFinder	1	1.000	-	-		FOG0001633
OrthoInspector	1	1.000	-	-		otm44881
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23401
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1362
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.860