Protein Alignment Cdk5alpha and Cdk5r2

DIOPT Version :9

• Sequence 1: NP_001260320.1
• Gene: Cdk5alpha / 34385
• FlyBaseID: FBgn0027491
• Length: 472
• Species: Drosophila melanogaster
• Sequence 2: NP_034002.2
• Gene: Cdk5r2 / 12570
• MGIID: 1330828
• Length: 369
• Species: Mus musculus
• Alignment Length: 343
• Identity: 127/343 - (37%)
• Similarity: 167/343 - (48%)
• Gaps: 75/343 - (21%)

  Fly   130 EKNLKKHSIFINALSWKKLSTSHNKKKIENKNKCANLPTACFKAQLLESSFASSSDKNRNIQLHC 194
            |..||:.|:.|:||:||:|..:..||| :...|....|.:.....|::       .:||...|..
Mouse    51 ESRLKRPSVLISALTWKRLVAASAKKK-KGSKKVTPKPASTGPDPLVQ-------QRNRENLLRK 107

  Fly   195 NRIDEHNQQHCNQHPHPHPHQHQLQLQNQHQHQNQNQNQNQNQVQDIREEVMT-----------G 248
            .|..............|.|                          .:.....|           .
Mouse   108 GRDGPDGGGTAKPLAVPVP--------------------------TVPTTAATCEPPSGGSAAAP 146

  Fly   249 PPGKSQNPSKAKDPVKVNNKNSMSNHNKLIQKQPLTLSLPQQVQASSIQTKNTNQIPRKTVIQAS 313
            |||..........|                   |...:.|.....|          ||:.::|||
Mouse   147 PPGSGGGKPPPPPP-------------------PAPQAAPPAPGGS----------PRRVIVQAS 182

  Fly   314 TSELLKCLGMFLHCRCQRLNNFDAGDAVMWLRAVDRSLLLQGWQDVAFINPANVVFVYMLVRELV 378
            |.|||:|||.|:..||.||.....|:.|.|.|.||||||||||||.|||.|||:||||:|.||.:
Mouse   183 TGELLRCLGDFVCRRCYRLKELSPGELVGWFRGVDRSLLLQGWQDQAFITPANLVFVYLLCRESL 247

  Fly   379 SGEE-SKESDLQASVLTCLYLSYSYMGNEISYPLKPFLVEDSKEKFWDRCLVIVNKLSDKMLKIN 442
            .|:| :..::|||:.||||||:||||||||||||||||||..||:||.|||.::.:||.:||::|
Mouse   248 RGDELASAAELQAAFLTCLYLAYSYMGNEISYPLKPFLVEPDKERFWQRCLRLIQRLSPQMLRLN 312

  Fly   443 AEPGFFTEVFTELKSCGQ 460
            |:|.|||:||.:||:.|:
Mouse   313 ADPHFFTQVFQDLKNEGE 330

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cdk5alpha	NP_001260320.1	CDK5_activator	107..458	CDD:281279	126/339 (37%)
Cdk5r2	NP_034002.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..55		1/3 (33%)
		CDK5_activator	51..329	CDD:308730	126/340 (37%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	72..176		21/166 (13%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	330..369		0/1 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847833
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG3932
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	237	1.000	Inparanoid score	I3375
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001633
OrthoInspector	1	1.000	-	-		otm42814
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23401
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1362
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	10	9.850