DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5390 and PRSS12

DIOPT Version :9

Sequence 1:	NP_001285802.1	Gene:	CG5390 / 34383	FlyBaseID:	FBgn0032213	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	NP_003610.2	Gene:	PRSS12 / 8492	HGNCID:	9477	Length:	875	Species:	Homo sapiens

Alignment Length:	358	Identity:	92/358 - (25%)
Similarity:	152/358 - (42%)	Gaps:	59/358 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 DSSGSTGSENGGSSSTQYQSCGDQKECVPRWLCANDTINTSGDGIIDIRLGTDAECKNYLDLCCD 115
            |:...||:|         :|..|   |:.:.:..::..::...|:|....|..|.
Human   565 DNVKCTGNE---------RSLAD---CIKQDIGRHNCRHSEDAGVICDYFGKKAS---------- 607

  Fly   116 LPNKRKDPIFEFKPDHPEGCGYQNPNGVGFKITGAVNQEAEFGEFPWMLAI-LREEGNLNLYECG 179
             .|..|:.:...       ||.:..:....:|.|..|...  |.:||.::: |:.........||
Human   608 -GNSNKESLSSV-------CGLRLLHRRQKRIIGGKNSLR--GGWPWQVSLRLKSSHGDGRLLCG 662

  Fly   180 GALIAPNVVLTAAHCV--HNKQPSSIVVRAGEWDTQTQTEIRRHEDRYVKEIIYHEQFNKGSLYN 242
            ..|::...|||||||.  :.....|..||.|::.|....|.  .|:..|::|:.|.::.......
Human   663 ATLLSSCWVLTAAHCFKRYGNSTRSYAVRVGDYHTLVPEEF--EEEIGVQQIVIHREYRPDRSDY 725

  Fly   243 DVAVMLLESP----FTLQENIQTVCLP--NVGDKFDFDRCYATGWGKNKFGKDGEYQVILKKVDM 301
            |:|::.|:.|    .....::...|||  ....:.....||.||||..  |:  .|...|::..:
Human   726 DIALVRLQGPEEQCARFSSHVLPACLPLWRERPQKTASNCYITGWGDT--GR--AYSRTLQQAAI 786

  Fly   302 PVVPEQQCETNLRETRLGRHFILHDSFICAGG---EKDKDTCKGDGGSPLVCPIAGQKNRFKSAG 363
            |::|::.||...:....||       .:|||.   .|..|:|:||.|.||:|...|:.  :...|
Human   787 PLLPKRFCEERYKGRFTGR-------MLCAGNLHEHKRVDSCQGDSGGPLMCERPGES--WVVYG 842

  Fly   364 IVAWGIGCGEVNIPGVYASVAKLRPWIDAKLKI 396
            :.:||.|||..:.||||..|:...|||.:..|:
Human   843 VTSWGYGCGVKDSPGVYTKVSAFVPWIKSVTKL 875

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5390	NP_001285802.1	Tryp_SPc	153..391	CDD:238113	72/249 (29%)
CG5390	NP_001285802.1	Tryp_SPc	153..390	CDD:214473	71/248 (29%)
PRSS12	NP_003610.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	29..88
		KR	99..164	CDD:214527
		SR	170..270	CDD:214555
		SRCR	175..270	CDD:278931
		SR	280..380	CDD:214555
		SRCR	285..380	CDD:278931
		SR	387..486	CDD:214555
		SRCR	392..485	CDD:278931
		SR	500..599	CDD:214555	8/45 (18%)
		SRCR	510..599	CDD:278931	8/45 (18%)
		Zymogen activation region	619..630		2/10 (20%)
		Tryp_SPc	630..869	CDD:214473	74/255 (29%)
		Tryp_SPc	631..872	CDD:238113	76/257 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910