DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5390 and PLG

DIOPT Version :9

Sequence 1:	NP_001285802.1	Gene:	CG5390 / 34383	FlyBaseID:	FBgn0032213	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	NP_000292.1	Gene:	PLG / 5340	HGNCID:	9071	Length:	810	Species:	Homo sapiens

Alignment Length:	427	Identity:	117/427 - (27%)
Similarity:	181/427 - (42%)	Gaps:	102/427 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 CGAQDSSLDKLISDIFKTDETPKPSSPPPPVV------NPKDSSGSTGSENG--GSSSTQYQS-- 70
            |...|.|:.....::.|...|......|||||      .|.:.....|:..|  |..:|....
Human   437 CFTTDPSVRWEYCNLKKCSGTEASVVAPPPVVLLPDVETPSEEDCMFGNGKGYRGKRATTVTGTP 501

  Fly    71 CGDQKECVPRWLCANDTINTSGDGIIDIRLGTDAECKNYLDLC---------------------- 113
            |.|       |.......::......:.|.|.:   |||   |
Human   502 CQD-------WAAQEPHRHSIFTPETNPRAGLE---KNY---CRNPDGDVGGPWCYTTNPRKLYD 553

  Fly   114 -CDLPNKRKDPIFEF-KPD-HPEGCGYQNPNGVGFKITGAVNQEAEFGEFPWMLAILREEGNLNL 175
             ||:| :...|.|:. ||. .|:.|    |..|   :.|.|   |....:||.:::....|   :
Human   554 YCDVP-QCAAPSFDCGKPQVEPKKC----PGRV---VGGCV---AHPHSWPWQVSLRTRFG---M 604

  Fly   176 YECGGALIAPNVVLTAAHCVH-NKQPSSIVVRAGEWDTQTQTEIRRHEDRYVKEI----IYHEQF 235
            :.|||.||:|..|||||||:. :.:|||..|..|   ...:..:..|    |:||    ::.|..
Human   605 HFCGGTLISPEWVLTAAHCLEKSPRPSSYKVILG---AHQEVNLEPH----VQEIEVSRLFLEPT 662

  Fly   236 NKGSLYNDVAVMLLESPFTLQENIQTVCLPN----VGDKFDFDRCYATGWGKNK--FGKDGEYQV 294
            .|     |:|::.|.||..:.:.:...|||:    |.|:.:   |:.||||:.:  ||..
Human   663 RK-----DIALLKLSSPAVITDKVIPACLPSPNYVVADRTE---CFITGWGETQGTFGAG----- 714

  Fly   295 ILKKVDMPVVPEQQCETNLRETRLGRHFILHDSFICAGG-EKDKDTCKGDGGSPLVCPIAGQKNR 358
            :||:..:||:..:.|  |..|...||   :..:.:|||. ....|:|:||.|.||||   .:|::
Human   715 LLKEAQLPVIENKVC--NRYEFLNGR---VQSTELCAGHLAGGTDSCQGDSGGPLVC---FEKDK 771

  Fly   359 FKSAGIVAWGIGCGEVNIPGVYASVAKLRPWIDAKLK 395
            :...|:.:||:||...|.||||..|::...||:..::
Human   772 YILQGVTSWGLGCARPNKPGVYVRVSRFVTWIEGVMR 808

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5390	NP_001285802.1	Tryp_SPc	153..391	CDD:238113	79/249 (32%)
CG5390	NP_001285802.1	Tryp_SPc	153..390	CDD:214473	78/248 (31%)
PLG	NP_000292.1	PAN_AP_HGF	<38..97	CDD:238532
		KR	101..183	CDD:214527
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	126..145
		KR	183..263	CDD:214527
		KR	273..354	CDD:214527
		KR	375..456	CDD:214527	4/18 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	396..416
		KR	479..560	CDD:214527	16/94 (17%)
		Tryp_SPc	580..803	CDD:214473	81/259 (31%)
		Tryp_SPc	581..804	CDD:238113	82/259 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910