DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5390 and LPA

DIOPT Version :9

Sequence 1:	NP_001285802.1	Gene:	CG5390 / 34383	FlyBaseID:	FBgn0032213	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	NP_005568.2	Gene:	LPA / 4018	HGNCID:	6667	Length:	2040	Species:	Homo sapiens

Alignment Length:	411	Identity:	104/411 - (25%)
Similarity:	168/411 - (40%)	Gaps:	79/411 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 CGAQDSSLDKLISDIFKTDETPKPSSPPPPVVN------PKDSSGSTGSENG--GSSSTQYQSCG 72
            |...|.|:.....::.:..:|......||.|:.      |.:.....|:..|  |..:|......
Human  1676 CFTMDPSIRWEYCNLTRCSDTEGTVVAPPTVIQVPSLGPPSEQDCMFGNGKGYRGKKATTVTGTP 1740

  Fly    73 DQK----------ECVP---RWLCANDTINTSGDGIIDIRLGTDAECKNYLDLCCDLPNKRKDPI 124
            .|:          ..:|   :|.........:.||.|:.........:...|. ||:|.......
Human  1741 CQEWAAQEPHRHSTFIPGTNKWAGLEKNYCRNPDGDINGPWCYTMNPRKLFDY-CDIPLCASSSF 1804

  Fly   125 FEFKPD-HPEGCGYQNPNGVGFKITGAVNQEAEFGEFPWMLAILREEGNLNLYECGGALIAPNVV 188
            ...||. .|:.|    |..:   :.|.|   |....:||.:::....|.   :.|||.||:|..|
Human  1805 DCGKPQVEPKKC----PGSI---VGGCV---AHPHSWPWQVSLRTRFGK---HFCGGTLISPEWV 1856

  Fly   189 LTAAHCV-HNKQPSSIVVRAGEWDTQTQTEIRRHEDRYVKEIIYHEQFNKGSLYNDVAVMLLESP 252
            ||||||: .:.:|||..|..|   ...:..:..|    |:||.....|.:.: ..|:|::.|..|
Human  1857 LTAAHCLKKSSRPSSYKVILG---AHQEVNLESH----VQEIEVSRLFLEPT-QADIALLKLSRP 1913

  Fly   253 FTLQENIQTVCLPNVGDKFDF-----DRCYATGWGKNK--FGKDGEYQVILKKVDMPVVPEQQCE 310
            ..:.:.:...|||:.    |:     ..||.||||:.:  ||..     :||:..:.|:..:.|.
Human  1914 AVITDKVMPACLPSP----DYMVTARTECYITGWGETQGTFGTG-----LLKEAQLLVIENEVCN 1969

  Fly   311 TNLRETRLGRHFILHDSFICAGG-EKDKDTCKGDGGSPLVCPIAGQKNRFKSAGIVAWGIGCGEV 374
                          |..:|||.. .:..|:|:||.|.||||   .:|:::...|:.:||:||...
Human  1970 --------------HYKYICAEHLARGTDSCQGDSGGPLVC---FEKDKYILQGVTSWGLGCARP 2017

  Fly   375 NIPGVYASVAKLRPWIDAKLK 395
            |.|||||.|::...||:..::
Human  2018 NKPGVYARVSRFVTWIEGMMR 2038

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5390	NP_001285802.1	Tryp_SPc	153..391	CDD:238113	74/246 (30%)
CG5390	NP_001285802.1	Tryp_SPc	153..390	CDD:214473	73/245 (30%)
LPA	NP_005568.2	Kringle	28..105	CDD:278480
		Kringle	142..219	CDD:278480
		Kringle	256..333	CDD:278480
		Kringle	370..447	CDD:278480
		Kringle	484..561	CDD:278480
		Kringle	598..675	CDD:278480
		Kringle	712..789	CDD:278480
		Kringle	826..903	CDD:278480
		KR	938..1019	CDD:214527
		Kringle	1054..1131	CDD:278480
		KR	1166..1246	CDD:214527
		KR	1272..1352	CDD:214527
		KR	1386..1466	CDD:214527
		KR	1500..1581	CDD:214527
		KR	1614..1695	CDD:214527	3/18 (17%)
		Kringle	1720..1799	CDD:278480	14/79 (18%)
		Tryp_SPc	1820..2034	CDD:238113	76/256 (30%)
		Tryp_SPc	1820..2033	CDD:214473	75/255 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910