DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5390 and TMPRSS7

DIOPT Version :9

Sequence 1:	NP_001285802.1	Gene:	CG5390 / 34383	FlyBaseID:	FBgn0032213	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	NP_001382436.1	Gene:	TMPRSS7 / 344805	HGNCID:	30846	Length:	843	Species:	Homo sapiens

Alignment Length:	398	Identity:	109/398 - (27%)
Similarity:	164/398 - (41%)	Gaps:	91/398 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    41 SPPPPVVNPKDSSGSTGSENGGSSSTQYQSC---------GDQKECV-PRWLCANDTINTSG--- 92
            |.|.||.:.:.||        |....|.|.|         .|:..|| |:..|...:....|
Human   481 SQPCPVGSFRCSS--------GLCVPQAQRCDGVNDCFDESDELFCVSPQPACNTSSFRQHGPLI 537

  Fly    93 -DGIIDIRLGTDAE-------CKNYL-----DLCCDLPNKRKDPIFEFKPD--HPEGCGYQNPNG 142
             ||..|...|.|.:       |.|..     |:|....|.:.|...:. ||  ..|||.....:.
Human   538 CDGFRDCENGRDEQNCTQSIPCNNRTFKCGNDICFRKQNAKCDGTVDC-PDGSDEEGCTCSRSSS 601

  Fly   143 VGFKITGAVNQEAEFGEFPWMLAILREEGNLNLYECGGALIAPNVVLTAAHCVHNKQPSSIVVRA 207
            ...:|.|..  :...|.:||.:: |...|:.   .||.::|:...:|:||||.|..:.|.
Human   602 ALHRIIGGT--DTLEGGWPWQVS-LHFVGSA---YCGASVISREWLLSAAHCFHGNRLSD----- 655

  Fly   208 GEWDTQTQTEIRRHEDRY----------VKEIIYHEQFNKGSLYNDVAVMLLES--PFTLQENIQ 260
                   .|....|...|          |:.|:.||.:|..:...|:|::.|..  |.||::.||
Human   656 -------PTPWTAHLGMYVQGNAKFVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQ 713

  Fly   261 TVCLPNVGDKF-DFDRCYATGWGKNKFGKDGEYQVILKKVDMPVVPEQQCETNLRETRLGRHFIL 324
            .:|:|..|.:. ..::|:.||||: :...|.:..::|::.::.::.:..|        :..:.|:
Human   714 PICIPPTGQRVRSGEKCWVTGWGR-RHEADNKGSLVLQQAEVELIDQTLC--------VSTYGII 769

  Fly   325 HDSFICAGGEKDK-DTCKGDGGSPLVCPIAGQKNRFKS------AGIVAWGIGCGEVNIPGVYAS 382
            ....:|||....| |.||||.|.||.|       |.||      .|||:||.|.|..|.||||..
Human   770 TSRMLCAGIMSGKRDACKGDSGGPLSC-------RRKSDGKWILTGIVSWGHGSGRPNFPGVYTR 827

  Fly   383 VAKLRPWI 390
            |:...|||
Human   828 VSNFVPWI 835

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5390	NP_001285802.1	Tryp_SPc	153..391	CDD:238113	75/258 (29%)
CG5390	NP_001285802.1	Tryp_SPc	153..390	CDD:214473	73/256 (29%)
TMPRSS7	NP_001382436.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	27..67
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910