DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5390 and OVCH1

DIOPT Version :9

Sequence 1:	NP_001285802.1	Gene:	CG5390 / 34383	FlyBaseID:	FBgn0032213	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	XP_024304736.1	Gene:	OVCH1 / 341350	HGNCID:	23080	Length:	1120	Species:	Homo sapiens

Alignment Length:	461	Identity:	125/461 - (27%)
Similarity:	186/461 - (40%)	Gaps:	111/461 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    25 KLISDIFKTDETPKPSSPPPPVVNPKDSSGS-------------TGS---------ENGGSSSTQ 67
            |:...|..:....:.|....|.|:..:.|||             .||         |.|.:.|.:
Human   406 KVCGKILPSPLLAETSEAMVPFVSDTEDSGSGFELTVTAVQKSEAGSGCGSLAILVEEGTNHSAK 470

  Fly    68 YQS------------CGDQKECV------------PRWLCANDTINTSGD-----------GIID 97
            |..            |..:|..:            |.  |..|.:...||           |::.
Human   471 YPDLYPSNTRCHWFICAPEKHIIKLTFEDFAVKFSPN--CIYDAVVIYGDSEEKHKLAKLCGMLT 533

  Fly    98 IR----------LGTDAECKNYLD--------LCCDLPNK-------RKDPIFEFKPDHPEGCGY 137
            |.          :...::.||.|.        |..:..||       :.:|:...|....:.||.
Human   534 ITSIFSSSNMTVIYFKSDGKNRLQGFKARFTILPSESLNKFEPKLPPQNNPVSTVKAILHDVCGI 598

  Fly   138 Q--NPNGVGFKITGAVNQEAEFGEFPWMLAILREEGNLNLYECGGALIAPNVVLTAAHCVHNK-Q 199
            .  :|..:..:|.|  .:||....:||.:. ||..|:   |:||||:|.|..:|||||||..| .
Human   599 PPFSPQWLSRRIAG--GEEACPHCWPWQVG-LRFLGD---YQCGGAIINPVWILTAAHCVQLKNN 657

  Fly   200 PSSIVVRAGEWD---TQTQTEIRRHEDRYVKEIIYHEQFNKGSLYNDVAVMLLESPFTLQENIQT 261
            |.|..:.||:.|   .::..::||     .|.||.||.||..|..:|:|::.|.||......::.
Human   658 PLSWTIIAGDHDRNLKESTEQVRR-----AKHIIVHEDFNTLSYDSDIALIQLSSPLEYNSVVRP 717

  Fly   262 VCLPNVGDK-FDFDRCYATGWGKNKFGKDGEYQVILKKVDMPVVPEQQCETNLRETRLGRHFILH 325
            ||||:..:. |..:.|..||||  ....||.....|:::.:.|:..:.||........|.   :.
Human   718 VCLPHSAEPLFSSEICAVTGWG--SISADGGLASRLQQIQVHVLEREVCEHTYYSAHPGG---IT 777

  Fly   326 DSFICAG--GEKDKDTCKGDGGSPLVCPIAGQKNRFKSAGIVAWGIGCGEVNIPGVYASVAKLRP 388
            :..||||  ...:||.|:||.|.||||  ..:...|...|||:||.||.:...|||:|.|.....
Human   778 EKMICAGFAASGEKDFCQGDSGGPLVC--RHENGPFVLYGIVSWGAGCVQPWKPGVFARVMIFLD 840

  Fly   389 WIDAKL 394
            ||.:|:
Human   841 WIQSKI 846

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5390	NP_001285802.1	Tryp_SPc	153..391	CDD:238113	87/244 (36%)
CG5390	NP_001285802.1	Tryp_SPc	153..390	CDD:214473	86/243 (35%)
OVCH1	XP_024304736.1	Tryp_SPc	58..294	CDD:238113
		CUB	336..444	CDD:238001	8/37 (22%)
		CUB	454..565	CDD:238001	16/112 (14%)
		Tryp_SPc	610..845	CDD:238113	90/252 (36%)
		CUB	881..978	CDD:238001
		CUB	1017..1119	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910