DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5390 and OVCH2

DIOPT Version :9

Sequence 1:	NP_001285802.1	Gene:	CG5390 / 34383	FlyBaseID:	FBgn0032213	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	XP_016873148.1	Gene:	OVCH2 / 341277	HGNCID:	29970	Length:	569	Species:	Homo sapiens

Alignment Length:	262	Identity:	72/262 - (27%)
Similarity:	139/262 - (53%)	Gaps:	35/262 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly   146 KITGAVNQEAEFGEFPWMLAILREEGNLNLYECGGALIAPNVVLTAAHCVHNKQ-PSSIVVRAGE 209
            :|.|  ..:.|.|.:||.:::.:.:.::    |||::::|..|:|||||:.|:. .|::.|.|||
Human    55 RILG--GSQVEKGSYPWQVSLKQRQKHI----CGGSIVSPQWVITAAHCIANRNIVSTLNVTAGE 113

  Fly   210 WDTQTQTEIRRHEDRYVKEIIYHEQFN-KGSLYNDVAVMLLESPFTLQENIQTVCLPNVGDKFDF 273
            :|. :||: ...:...::.:|.|..|: |..:..|:|::.:...|.....:..:|||.:.::|:.
Human   114 YDL-SQTD-PGEQTLTIETVIIHPHFSTKKPMDYDIALLKMAGAFQFGHFVGPICLPELREQFEA 176

  Fly   274 D-RCYATGWGKNKFGKDGEYQVILKKVDMPVVPEQQCET---NLRETRLGRHFILHDSFICAG-G 333
            . .|...|||:...|  |....:|::|::|::..::|..   .|:....|:      :|:|.| .
Human   177 GFICTTAGWGRLTEG--GVLSQVLQEVNLPILTWEECVAALLTLKRPISGK------TFLCTGFP 233

  Fly   334 EKDKDTCKGDGGSPLVCPIAGQKNRFKSAGIVAWGIGCG----------EVNIPGVYASVAKLRP 388
            :..:|.|:||.|..|:|  ..:|..:..||:.:||:|||          :...||::..::|:.|
Human   234 DGGRDACQGDSGGSLMC--RNKKGAWTLAGVTSWGLGCGRGWRNNVRKSDQGSPGIFTDISKVLP 296

  Fly   389 WI 390
            ||
Human   297 WI 298

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5390	NP_001285802.1	Tryp_SPc	153..391	CDD:238113	70/255 (27%)
CG5390	NP_001285802.1	Tryp_SPc	153..390	CDD:214473	68/253 (27%)
OVCH2	XP_016873148.1	Tryp_SPc	55..298	CDD:214473	70/260 (27%)
		Tryp_SPc	56..301	CDD:238113	72/261 (28%)
		CUB	320..424	CDD:238001
		CUB	435..546	CDD:238001
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910