DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5390 and HGFAC

DIOPT Version :9

Sequence 1:	NP_001285802.1	Gene:	CG5390 / 34383	FlyBaseID:	FBgn0032213	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	NP_001284368.1	Gene:	HGFAC / 3083	HGNCID:	4894	Length:	662	Species:	Homo sapiens

Alignment Length:	348	Identity:	88/348 - (25%)
Similarity:	147/348 - (42%)	Gaps:	78/348 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 LGTDAECKN---------YL--------DLC----CDLPNKRKDPI--FEFKPD----HPEGCGY 137
            ||..|.|:|         |:        :.|    |||..:.::.:  .:..||    .||
Human   332 LGPHAYCRNPDNDERPWCYVVKDSALSWEYCRLEACDLETEGRESLTRVQLSPDLLATLPE---- 392

  Fly   138 QNPNGVGFKITGAVNQEAEF-------------GEFPWMLAILREEGNLNLYECGGALIAPNVVL 189
              |...|.:..|..:::..|             |..||:.||...:.     .|.|:|:....|:
Human   393 --PASPGRQACGRRHKKRTFLRPRIIGGSSSLPGSHPWLAAIYIGDS-----FCAGSLVHTCWVV 450

  Fly   190 TAAHCVHNKQP-SSIVVRAGEWDTQTQTEIRR--HEDRYVKEIIYHEQFNKGSLYNDVAVMLLES 251
            :||||..:..| .|:.|..|:......|::.:  ..::|:...:| ..||...  :|:.::.|:.
Human   451 SAAHCFSHSPPRDSVSVVLGQHFFNRTTDVTQTFGIEKYIPYTLY-SVFNPSD--HDLVLIRLKK 512

  Fly   252 P----FTLQENIQTVCLPNVGDKFDF-DRCYATGWG---KNKFGKDGEYQVILKKVDMPVVPEQQ 308
            .    .|..:.:|.:|||..|..|.. .:|...|||   :|..|    |...|::..:|:|.:.:
Human   513 KGDRCATRSQFVQPICLPEPGSTFPAGHKCQIAGWGHLDENVSG----YSSSLREALVPLVADHK 573

  Fly   309 CETNLRETRLGRHFILHDSFICAG-GEKDKDTCKGDGGSPLVCPIAGQKNRFKSAGIVAWGIGCG 372
            |.:   ....|..  :..:.:||| .:...|.|:||.|.||.|...|....:   ||::||.|||
Human   574 CSS---PEVYGAD--ISPNMLCAGYFDCKSDACQGDSGGPLACEKNGVAYLY---GIISWGDGCG 630

  Fly   373 EVNIPGVYASVAKLRPWIDAKLK 395
            .::.||||..||....||:.:::
Human   631 RLHKPGVYTRVANYVDWINDRIR 653

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5390	NP_001285802.1	Tryp_SPc	153..391	CDD:238113	70/262 (27%)
CG5390	NP_001285802.1	Tryp_SPc	153..390	CDD:214473	69/261 (26%)
HGFAC	NP_001284368.1	PRR18	34..>169	CDD:292299
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	64..102
		FN2	102..148	CDD:128373
		EGF_CA	162..197	CDD:238011
		FN1	200..240	CDD:238018
		EGF_CA	245..278	CDD:238011
		Kringle	286..367	CDD:278480	7/34 (21%)
		Tryp_SPc	414..648	CDD:214473	68/253 (27%)
		Tryp_SPc	415..650	CDD:238113	70/254 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910