DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG5390 and F2

DIOPT Version :9

Sequence 1:	NP_001285802.1	Gene:	CG5390 / 34383	FlyBaseID:	FBgn0032213	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	NP_075213.2	Gene:	F2 / 29251	RGDID:	61996	Length:	617	Species:	Rattus norvegicus

Alignment Length:	340	Identity:	98/340 - (28%)
Similarity:	149/340 - (43%)	Gaps:	68/340 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 NTSGDGIIDIRLGTDAECKNYLD--------LCCDLPNKRKDPIFEFK--PDHPEGCGYQNPNGV 143
            |..||..|..|. ||||...:.|        ..|.|     .|:||.|  .|..|      ...:
  Rat   300 NHDGDESIAGRT-TDAEFHTFFDERTFGLGEADCGL-----RPLFEKKSLTDKTE------KELL 352

  Fly   144 GFKITGAVNQ--EAEFGEFPWMLAILREEGNLNLYECGGALIAPNVVLTAAHCV------HNKQP 200
            ...|.|.:.:  :||.|..||.:.:.|:.....|  ||.:||:...|||||||:      .|...
  Rat   353 DSYIDGRIVEGWDAEKGIAPWQVMLFRKSPQELL--CGASLISDRWVLTAAHCILYPPWDKNFTE 415

  Fly   201 SSIVVRAGEWDTQTQTEIRRHEDR--YVKEIIYHEQFN-KGSLYNDVAVMLLESPFTLQENIQTV 262
            :.::||.|:   .::|...|:.::  .:::|..|.::| :.:|..|:|::.|:.|....:.|..|
  Rat   416 NDLLVRIGK---HSRTRYERNVEKISMLEKIYIHPRYNWRENLDRDIALLKLKKPVPFSDYIHPV 477

  Fly   263 CLPNVGDKFDFD-------RCYATGWGKNK---FGKDGEYQ-VILKKVDMPVVPEQQCE--TNLR 314
            |||   ||....       :...||||..:   .....|.| .:|:.|::|:|....|:  |.:|
  Rat   478 CLP---DKQTVTSLLQAGYKGRVTGWGNLRETWTTNINEIQPSVLQVVNLPIVERPVCKASTRIR 539

  Fly   315 ETRLGRHFILHDSFICAG----GEKDKDTCKGDGGSPLVCPIAGQKNRFKSAGIVAWGIGCGEVN 375
            .|         |:..|||    ..|..|.|:||.|.|.|.. :...:|:...|||:||.||....
  Rat   540 IT---------DNMFCAGFKVNDTKRGDACEGDSGGPFVMK-SPYNHRWYQMGIVSWGEGCDRNG 594

  Fly   376 IPGVYASVAKLRPWI 390
            ..|.|..|.:|:.|:
  Rat   595 KYGFYTHVFRLKRWM 609

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5390	NP_001285802.1	Tryp_SPc	153..391	CDD:238113	78/266 (29%)
CG5390	NP_001285802.1	Tryp_SPc	153..390	CDD:214473	77/264 (29%)
F2	NP_075213.2	GLA	25..89	CDD:214503
		KR	107..189	CDD:214527
		Kringle	215..292	CDD:278480
		Thrombin_light	312..359	CDD:286482	14/57 (25%)
		Tryp_SPc	359..608	CDD:214473	77/266 (29%)
		Tryp_SPc	360..612	CDD:238113	78/268 (29%)
		High affinity receptor-binding region which is also known as the TP508 peptide	547..569		9/21 (43%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910