DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5390 and tmprss2.15

DIOPT Version :9

Sequence 1:	NP_001285802.1	Gene:	CG5390 / 34383	FlyBaseID:	FBgn0032213	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	XP_031752206.1	Gene:	tmprss2.15 / 101732233	XenbaseID:	XB-GENE-22065943	Length:	504	Species:	Xenopus tropicalis

Alignment Length:	428	Identity:	105/428 - (24%)
Similarity:	173/428 - (40%)	Gaps:	88/428 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 CLVIC----LCIF---------SC--GAQDSSLDKLISDIFKTDETPKPSSPPPPVVNPK--DSS 53
            |.::|    :|:.         .|  |..:.:..:|....|:........:...||...:  |:|
Frog   127 CQMLCGSSGVCVLYSQWCDGIPQCPNGTDEQTCVRLYGPNFQLQAYSPAKATWLPVCYDEWSDNS 191

  Fly    54 GSTGSEN-GGSSSTQYQSCGDQKECVPRWLCANDTINTSGDGIIDIR-----------LGTDAEC 106
            |....:: |.|.|:.|||              :..:.:|.:|...::           |...|.|
Frog   192 GKIACQDIGYSMSSYYQS--------------SQLLASSSNGYFVLQSSNVTGKMYTNLNYSATC 242

  Fly   107 K--NYLDLCCDLPNKRKDPIFEFKPDHPEGCGYQNPNGVGFKITGAVNQEAEFGEFPWMLAILRE 169
            .  |.:.|.|                  ..||....  |..:|.|..  .|..|::||.:.:|:.
Frog   243 ASGNMVSLRC------------------ISCGLSTK--VDSRIVGGT--PASVGDWPWQVELLKL 285

  Fly   170 EGNLNLYECGGALIAPNVVLTAAHCVH--NKQPSSIVVRAGEWDTQTQTEIRRHEDRY-VKEIIY 231
            .|. ::|.|||::|.|:.::||||||:  ...||:..|.||....|:.     :...| |:..:.
Frog   286 VGT-SIYLCGGSIITPHWIVTAAHCVYGSTSTPSAFKVFAGSLTIQSY-----YSAGYTVERALV 344

  Fly   232 HEQFNKGSLYNDVAVMLLESPFTLQENIQTVCLPNVGDKF-DFDRCYATGWGKNKFGKDGEYQVI 295
            |..::..:...|||::.|.:......|::.|||||||..: :...|:.:|||....|  |.....
Frog   345 HPSYSSYTQIYDVALLKLTAALVFTTNLRPVCLPNVGMPWAEGQPCWISGWGTTAEG--GSISKN 407

  Fly   296 LKKVDMPVVPEQQCETNLRETRLGRHFILHDSFICAGG-EKDKDTCKGDGGSPLVCPIAGQKNRF 359
            |....:|::....|  |......|   .:..:.:|||. ....|||:||.|.|||   ....:.:
Frog   408 LMAASVPIISSTTC--NQAAVYGG---AISSTMMCAGYLSGGTDTCQGDSGGPLV---TKTNSLW 464

  Fly   360 KSAGIVAWGIGCGEVNIPGVYASVAKLRPWIDAKLKIW 397
            ...|..:||.||.....||||.:|.....||.::::.:
Frog   465 WLVGDTSWGYGCARAYKPGVYGNVTVFIEWIYSQMQTY 502

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5390	NP_001285802.1	Tryp_SPc	153..391	CDD:238113	73/242 (30%)
CG5390	NP_001285802.1	Tryp_SPc	153..390	CDD:214473	72/241 (30%)
tmprss2.15	XP_031752206.1	LDLa	93..121	CDD:238060
		SRCR_2	164..259	CDD:406055	22/126 (17%)
		Tryp_SPc	265..498	CDD:238113	76/250 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910