DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG5390 and tmprss2.2

DIOPT Version :9

Sequence 1:	NP_001285802.1	Gene:	CG5390 / 34383	FlyBaseID:	FBgn0032213	Length:	406	Species:	Drosophila melanogaster
Sequence 2:	XP_002941330.2	Gene:	tmprss2.2 / 100493729	XenbaseID:	XB-GENE-22065949	Length:	521	Species:	Xenopus tropicalis

Alignment Length:	398	Identity:	102/398 - (25%)
Similarity:	153/398 - (38%)	Gaps:	98/398 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 FSC---GAQDSSLDKLISDIFKTDETPKPSSPPPPVVNPKDSSGSTGSENGGSSSTQYQSCGDQK 75
            |:|   |...||.:       :::..|.|.:|          :|.....||..||..|.|..:..
Frog   209 FACRDFGYSGSSYN-------RSNTLPSPYAP----------NGYFKLNNGFGSSQFYTSVQNSS 256

  Fly    76 ECVPRWLCANDTINTSGDGIIDIRLGTDAECKNYLDLCCDLPNKRKDPIFEFKPDHPEGCGYQNP 140
            .|.            ||: ::.:|      |     :.|                   |..|
Frog   257 SCF------------SGN-VVSLR------C-----ISC-------------------GVSY--- 275

  Fly   141 NGVGFKITGAVNQEAEFGEFPWMLAILREEGNLNLYECGGALIAPNVVLTAAHCVHNKQPSSIVV 205
            |.|..:|.|..  .|.:|.:.|.:.:....|.|    |||::|:|..::||||||:.  ....::
Frog   276 NSVASRIVGGT--YAAYGNWLWQVGLRYNTGIL----CGGSIISPKWIVTAAHCVYG--TDGFLL 332

  Fly   206 RAGEW----DTQTQTEIRRHEDRYVKEIIYHEQFNKGSLYNDVAVMLLESPFTLQENIQTVCLPN 266
            .|..|    .|.|...........|:.||.|..:...|..||:|:|.|.:..|...|.|.|||||
Frog   333 SASGWRVFAGTLTLPSYYDSSGYLVERIIPHPGYKTSSNDNDIALMELSNGITFGYNTQPVCLPN 397

  Fly   267 VGDKFDFDR-CYATGWGKNKFGKDGEYQVILKKVDMPVVPEQQCETNLRETRLGRHFILHD---- 326
            .|..:.... |:.:|||....|  |.....|:...:.::....|..|         ::.:.
Frog   398 AGMFWSSGTPCWISGWGTTSQG--GSASTYLQYAAVQLIDSNVCNQN---------YVYNGQITA 451

  Fly   327 SFICAGG-EKDKDTCKGDGGSPLVCPIAGQKNRFKSAGIVAWGIGCGEVNIPGVYASVAKLRPWI 390
            |.||||. ....|:|:||.|.|||....|   .:...|..:||.||.:.|.||||.::.....||
Frog   452 SMICAGYLSGGVDSCQGDSGGPLVTKTNG---TWWLVGDTSWGYGCAQPNKPGVYGNMTSFLGWI 513

  Fly   391 DAKLKIWS 398
            ..:::..|
Frog   514 YLQMRTHS 521

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG5390	NP_001285802.1	Tryp_SPc	153..391	CDD:238113	73/247 (30%)
CG5390	NP_001285802.1	Tryp_SPc	153..390	CDD:214473	72/246 (29%)
tmprss2.2	XP_002941330.2	LDLa	<111..134	CDD:238060
		LDLa	145..174	CDD:238060
		SRCR_2	179..274	CDD:292133	22/124 (18%)
		Tryp_SPc	281..513	CDD:214473	74/253 (29%)
		Tryp_SPc	282..513	CDD:238113	74/252 (29%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X11
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000