Protein Alignment CG13138 and NEFH

DIOPT Version :9

• Sequence 1: NP_609372.1
• Gene: CG13138 / 34381
• FlyBaseID: FBgn0032211
• Length: 549
• Species: Drosophila melanogaster
• Sequence 2: NP_066554.2
• Gene: NEFH / 4744
• HGNCID: 7737
• Length: 1020
• Species: Homo sapiens
• Alignment Length: 591
• Identity: 121/591 - (20%)
• Similarity: 203/591 - (34%)
• Gaps: 149/591 - (25%)

  Fly    23 AHSNSYAVNKTNSVESAEW------SYPEYGKGSTHNTGRRSEKLDLQHYNRETERNVTLKRGVK 81
            |....:||..|  ::|.||      ...|..|.:|  ...||.:.::..|.|:.:...|
Human   276 AQLEGHAVQST--LQSEEWFRVRLDRLSEAAKVNT--DAMRSAQEEITEYRRQLQARTT------ 330

  Fly    82 NYQKQGDKMTRNKLKYKPSGARRKNVSPNYADESTESRHYHTFEEIHEHIDEDDGQYQASE-QVG 145
              :.:..|.|::.|:.:.|              ..|.||........|.|.:.|.:.:.:: ::.
Human   331 --ELEALKSTKDSLERQRS--------------ELEDRHQADIASYQEAIQQLDAELRNTKWEMA 379

  Fly   146 TQAILHEHVEHSSKKDAKRMKVKIKHHHHHHHHNHIKELIK-------------TVPQPYP-VEK 196
            .|  |.|:.:..:.|.|  :.::|..:         ::|::             ::|:..| :..
Human   380 AQ--LREYQDLLNVKMA--LDIEIAAY---------RKLLEGEECRIGFGPIPFSLPEGLPKIPS 431

  Fly   197 V-VHVPIEKIVEKIVHVPKLVNVTVEKIVHVPIEKIVEKVIHIPKPVQVPKPYVVEKIIEKI--- 257
            | .|:.: |..|||..|.|....||          |||:        |..:..|.|::.|:.
Human   432 VSTHIKV-KSEEKIKVVEKSEKETV----------IVEE--------QTEETQVTEEVTEEEEKE 477

  Fly   258 --------------------VHVPKPYPVLRTVPYPVEIKVPVHLEKKVPVPYK--VEVERKVPV 300
                                ....|..|.........|.|.||..|.|.|...|  .:.|.|.|.
Human   478 AKEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPA 542

  Fly   301 YIRSSE----PYKFESSSLYES-YPRGEEFKFNMEMDHP-----PPREHEPSSLPSSNYYNRIYK 355
            .::|.|    |.|.|:.|..|: .|..||.|...|:..|     |.:|...|...:        |
Human   543 EVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEA--------K 599

  Fly   356 SRELDHPPRMEDYQSSV------------PTQLKHDYATKTNLDQQFKNEYVTKSSIDPQFKHDY 408
            |.|....|..|:.:|..            |.::|.....|:...::.|:....||....:.|...
Human   600 SPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPE 664

  Fly   409 VTKSSIDPQFKHDYVTKSSIDPQFKHDYVTKSSFDSQYNQEYVPKTSI--ESTSP--GRDGVSLK 469
            ..||.:..:.|.....||.:..:.|.....||....:.......|:.:  |:.||  .:..|..:
Human   665 KAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEE 729

  Fly   470 LVGP---PTPFNITGKDLETANSAPDFVNSSNVDLSPQESANAYRGMPFSIPFQFVQLQPMAFQS 531
            ...|   .:|.....|..|.|.| |:  .:..:|:...|:....:....|...:|    |...:|
Human   730 AKTPEKAKSPVKEEAKSPEKAKS-PE--KAKTLDVKSPEAKTPAKEEARSPADKF----PEKAKS 787

  Fly   532 PIHVEL 537
            |:..|:
Human   788 PVKEEV 793

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG13138	NP_609372.1	IMCp	188..279	CDD:289112	23/115 (20%)
NEFH	NP_066554.2	Head	1..100
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	58..83
		Filament	96..412	CDD:278467	32/174 (18%)
		Coil 1A	101..132
		Linker 1	133..145
		Coil 1B	146..244
		Linker 12	245..266
		Coil 2A	267..288		4/13 (31%)
		Linker 2	289..292		1/2 (50%)
		Coil 2B	293..413		25/156 (16%)
		BASP1	513..736	CDD:283191	54/230 (23%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910